Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Kenneth L. Seldeen"'
Autor:
Debanik Choudhury, Na Rong, Hamsa Vardini Senthil Kumar, Sydney Swedick, Ronel Z. Samuel, Pihu Mehrotra, John Toftegaard, Nika Rajabian, Ramkumar Thiyagarajan, Ashis K. Podder, Yulun Wu, Shahryar Shahini, Kenneth L. Seldeen, Bruce Troen, Pedro Lei, Stelios T. Andreadis
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113738- (2024)
Summary: Mitochondrial dysfunction is a hallmark of cellular senescence, with the loss of mitochondrial function identified as a potential causal factor contributing to senescence-associated decline in cellular functions. Our recent findings revealed
Externí odkaz:
https://doaj.org/article/7e0989fdc4cd4210b9b77af2703db105
Autor:
Kyu Hwan Kwack, Lixia Zhang, Elliot D. Kramer, Ramkumar Thiyagarajan, Natalie A. Lamb, Yukitomo Arao, Jonathan E. Bard, Kenneth L. Seldeen, Bruce R. Troen, Perry J. Blackshear, Scott I. Abrams, Keith L. Kirkwood
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Aging results in enhanced myelopoiesis, which is associated with an increased prevalence of myeloid leukemias and the production of myeloid-derived suppressor cells (MDSCs). Tristetraprolin (TTP) is an RNA binding protein that regulates immune-relate
Externí odkaz:
https://doaj.org/article/427ac34cc1534c908d01b12010e3fcba
Autor:
Debanik Choudhury, Na Rong, Izuagie Ikhapoh, Nika Rajabian, Georgios Tseropoulos, Yulun Wu, Pihu Mehrotra, Ramkumar Thiyagarajan, Aref Shahini, Kenneth L. Seldeen, Bruce R. Troen, Pedro Lei, Stelios T. Andreadis
Publikováno v:
Cell reports. 41(9)
Mitochondrial dysfunction, a hallmark of aging, has been associated with the onset of aging phenotypes and age-related diseases. Here, we report that impaired mitochondrial function is associated with increased glutamine catabolism in senescent human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d05fa712c1900956cdc42584c1f24baa
https://pubmed.ncbi.nlm.nih.gov/36450260
https://pubmed.ncbi.nlm.nih.gov/36450260
Autor:
Kenneth L. Seldeen, Bruce R. Troen, Alexander Jacob, Ramkumar Thiyagarajan, Jeyantt S. Sankaran, Richard J. Quigg, Stefan Judex, Jessy J. Alexander
Publikováno v:
Immunobiology. 223:761-771
Complement system is an important arm of the immune system that promotes inflammation. Complement Factor H (FH) is a critical regulator of the alternative complement pathway. Its absence causes pathology in different organs resulting in diseases such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b025d50e30df80ec8e1d28d47fac1c28
https://doi.org/10.1016/j.imbio.2018.07.023
https://doi.org/10.1016/j.imbio.2018.07.023
Autor:
Kenneth L. Seldeen, Bruce R. Troen
Publikováno v:
Advances in geriatric medicine and research
Frailty is a condition marked by greater susceptibility to adverse outcomes, including disability and mortality, which affects up to 50% of those 80 years of age and older. Concurrently, serum vitamin D insufficiency and deficiency, for which as many
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0692af42029da0a897737958534d924a
http://europepmc.org/articles/PMC7968870
http://europepmc.org/articles/PMC7968870
Autor:
Reem Nagi Berman, Brian Alexander MacDonald, Kenneth L. Seldeen, Ramkumar Thiyagarajan, Bruce R. Troen, Manhui Pang, Ginger Lasky, Carleara Weiss, Yonas Redae
Publikováno v:
Nutrients, Vol 12, Iss 3005, p 3005 (2020)
Nutrients
Volume 12
Issue 10
Nutrients
Volume 12
Issue 10
Low 25-OH serum vitamin D (VitD) is pervasive in older adults and linked to functional decline and progression of frailty. We have previously shown that chronic VitD insufficiency in “middle-aged” mice results in impaired anaerobic exercise capac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b6caefbb90841c7e4c872aeec6af1e8
https://www.mdpi.com/2072-6643/12/10/3005
https://www.mdpi.com/2072-6643/12/10/3005
Autor:
Maria Rodríguez-Gonzalez, Bruce R. Troen, Merced M Leiker, Manhui Pang, Zachary Sheridan, Norma J. Nowak, Jonathan E. Bard, Kenneth L. Seldeen, Mireya Hernandez
Publikováno v:
Aging (Albany NY)
Vitamin D insufficiency (serum 25-OH vitamin D < 30 ng/ml) affects 70-80% of the general population, yet the long-term impacts on physical performance and the progression of sarcopenia are poorly understood. We therefore followed 6-month-old male C57
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e64473c75ce8fe496aa0b159f9d2c49e
https://doi.org/10.18632/aging.101471
https://doi.org/10.18632/aging.101471
Autor:
Yonas Redae, Andrew Dynka, Aref Shahini, Kenneth L. Seldeen, Stelios T. Andreadis, Merced M Leiker, Ramkumar Thiyagarajan, Nika Rajabian, Bruce R. Troen
Publikováno v:
Nutrition
Objectives Nicotinamide adenine dinucleotide (NAD+), an essential cofactor for mitochondrial function, declines with aging, which may lead to impaired physical performance. Nicotinamide riboside (NR), a NAD+ precursor, restores cellular NAD+ levels.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9fd33f3f432c3c099676bb60cb607ee
https://doi.org/10.1016/j.nut.2021.111189
https://doi.org/10.1016/j.nut.2021.111189
Autor:
Manhui Pang, Ginger Lasky, Merced M Leiker, Bruce R. Troen, Kirkwood E. Personius, Kenneth L. Seldeen
Publikováno v:
The Journals of Gerontology: Series A. 73:429-437
Sarcopenia and frailty are highly prevalent in older individuals, increasing the risk of disability and loss of independence. High intensity interval training (HIIT) may provide a robust intervention for both sarcopenia and frailty by achieving both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::365e2d48b7e1392c180e74f49f4f2c25
https://doi.org/10.1093/gerona/glx120
https://doi.org/10.1093/gerona/glx120
Autor:
Denise K. Houston, Heather E. Whitson, Douglas P. Kiel, Sarah D. Berry, Clifford J. Rosen, Elena Volpi, Kenneth L. Seldeen, Cathleen S. Colón-Emeric, Roger A. Fielding, James P. White, Bruce R. Troen
Publikováno v:
J Am Geriatr Soc
This report summarizes the presentations and recommendations of the eleventh annual American Geriatrics Society and National Institute on Aging research conference, "Osteoporosis and Soft Tissue (Muscle/Fat) Disorders," on March 11-12, 2019, in Bethe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58f0d3acc114847f3f84ea221c513be6
https://pubmed.ncbi.nlm.nih.gov/31791114
https://pubmed.ncbi.nlm.nih.gov/31791114