Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Kenneth L. Feenstra"'
Publikováno v:
Current Drug Metabolism. 22:215-223
Background: Pharmacokinetic and pharmacodynamic assessment of ester-containing drugs can be impacted by hydrolysis of the drugs in plasma samples post blood collection. The impact is different in the plasma of different species. Objective: This study
Publikováno v:
Drug Metabolism Letters. 13:123-131
Background:There has been a lack of information about the inhibition of bovine medicines on bovine hepatic CYP450 at their commercial doses and dosing routes.Objective:The aim of this work was to assess the inhibition of 43 bovine medicines on bovine
Publikováno v:
Drug metabolism letters. 13(2)
There has been a lack of information about the inhibition of bovine medicines on bovine hepatic CYP450 at their commercial doses and dosing routes.The aim of this work was to assess the inhibition of 43 bovine medicines on bovine hepatic CYP450 using
Publikováno v:
Environmental toxicology and pharmacology. 65
Amitraz is an acaricide and insecticide widely used in agriculture and veterinary medicine. Although central nervous system (CNS) toxicity is one of major toxicities following oral ingestion of amitraz, the understanding of the cause of the toxicity
Autor:
Rodney R. Walters, Matthew J. Zaya, Jason Gagne, Julie A. White, Charles W. Locuson, Beth Miskimins Mills, Kenneth L. Feenstra
Publikováno v:
Drug Metabolism and Disposition. 38:396-404
Recombinant cytochrome P450 (P450) phenotyping, different approaches for estimating fraction metabolized (f(m)), and multiple measures of in vivo inhibitor exposure were tested for their ability to predict drug interaction magnitude in dogs. In previ
Autor:
J P Sams, Kenneth L. Feenstra, K. Chiba, S Yamazaki, M R Schuette, N. Ozawa, S Koike, J. G. Slatter, P T Daley-Yates, L A Adams, G. W. Peng, E C Bush
Publikováno v:
Xenobiotica. 32:907-924
1. Linezolid (ZYVOX), the first of a new class of antibiotics, the oxazolidinones, is approved for treatment of Gram-positive bacterial infections. 2. The aim was to determine the absorption, distribution, metabolism and excretion (ADME) of linezolid
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 37(3)
The preparation of bacterial membranes (“Bactosomes”) containing expressed canine (beagle) hepatic cytochromes P450 (P450s) is described. cDNAs from seven canine P450s were subcloned into inducible expression plasmids and, for the first time, cot