Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Kenneth L. Custer"'
Autor:
Jack Knorr, Russell Perry, Peter Chen, Corey Hebert, Richard E. Higgs, Mark D. Williams, Joseph Boscia, Bharat Mocherla, Masoud Azizad, Princy Kumar, Robert L. Gottlieb, Paul Klekotka, Dipak R. Patel, Ajay Nirula, Imad Shawa, Andra L. Blomkalns, Andrew C. Adams, Gregory D. Huhn, Kenneth L. Custer, Lei Shen, Timothy R. Holzer, Jason Morris, Philip J. Ebert, Andrew E. Schade, Jacob Van Naarden, Blaze investigators, Gerard J. Oakley, Jose Cardona, Janelle Sabo, Matan C. Dabora, Daniel Skovronsky, Chad Crystal, Barry Heller, Awawu Igbinadolor, Michael Dougan
Publikováno v:
Clinical Infectious Diseases. 75:e440-e449
Background Based on interim analyses and modeling data, lower doses of bamlanivimab and etesevimab together (700/1400 mg) were investigated to determine optimal dose and expand availability of treatment. Methods This Phase 3 portion of the BLAZE-1 tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c671bc65b6856e2a675f8baf6d6b7e3
https://doi.org/10.1093/cid/ciab912
https://doi.org/10.1093/cid/ciab912
Autor:
Gregory D. Huhn, Dipak R. Patel, Bharat Mocherla, Daniel Skovronsky, Kenneth L. Custer, Paul Klekotka, Imad Shawa, Andrew E. Schade, Janelle Sabo, Nicole L. Kallewaard, Michael Durante, Andrew C. Adams, Timothy R. Holzer, Ajay Nirula, Joseph Boscia, Masoud Azizad, Jose Cardona, Princy Kumar, Chad Crystal, Lei Shen, Peter Chen, Russell Perry, Corey Hebert, Richard E. Higgs, Robert L. Gottlieb, Matan C. Dabora, Philip J. Ebert, Jacob Van Naarden, Gerard J. Oakley, Jason Morris, Michael Dougan, Awawu Igbinadolor, Barry Heller
Publikováno v:
The New England Journal of Medicine
Background Patients with underlying medical conditions are at increased risk for severe coronavirus disease 2019 (Covid-19). Whereas vaccine-derived immunity develops over time, neutralizing monoclonal-antibody treatment provides immediate, passive i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::163d2b1d9fb708ea8c2b335a117a4a4b
https://doi.org/10.1056/nejmoa2102685
https://doi.org/10.1056/nejmoa2102685
Autor:
Ajay Nirula, Jason Morris, Valentina Stosor, Gerard J. Oakley, Robert L. Gottlieb, Gregory D. Huhn, Jacob Van Naarden, Bharat Mocherla, Peter Chen, Joseph Boscia, Janelle Sabo, Daniel Skovronsky, Dipak R. Patel, Kenneth L. Custer, Michael Durante, Lei Shen, Paul Klekotka, Imad Shawa, Andrew E. Schade, Andrew C. Adams, Jose Cardona, Barry Heller
Publikováno v:
New England Journal of Medicine
The New England Journal of Medicine
The New England Journal of Medicine
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (Covid-19), which is most frequently mild yet can be severe and life-threatening. Virus-neutralizing monoclonal antibodies are predicted to reduce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d6e5ff14295583c7465beec9f8d437a
https://doi.org/10.1056/nejmoa2029849
https://doi.org/10.1056/nejmoa2029849
Autor:
Andrew C. Adams, Jose Cardona, Barry Heller, Nicole L. Kallewaard, Jason Morris, Michael Durante, Bharat Mocherla, Richard E. Higgs, Valentina Stosor, Daniel Skovronsky, Joseph Boscia, Paul Klekotka, Princy Kumar, Imad Shawa, Robert L. Gottlieb, Ajay Nirula, Timothy R. Holzer, Lei Shen, Philip J. Ebert, Jacob Van Naarden, Gerard J. Oakley, Dipak R. Patel, Kenneth L. Custer, Andrew E. Schade, Janelle Sabo, Peter Chen, Gregory D. Huhn
Publikováno v:
JAMA. 325(7)
Importance: Coronavirus disease 2019 (COVID-19) continues to spread rapidly worldwide. Neutralizing antibodies are a potential treatment for COVID-19. Objective: To determine the effect of bamlanivimab monotherapy and combination therapy with bamlani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bce1969b4b650dacd3943f737ab763cf
https://pubmed.ncbi.nlm.nih.gov/33475716
https://pubmed.ncbi.nlm.nih.gov/33475716
Autor:
Myron S, Cohen, Ajay, Nirula, Mark J, Mulligan, Richard M, Novak, Mary, Marovich, Catherine, Yen, Alexander, Stemer, Stockton M, Mayer, David, Wohl, Blair, Brengle, Brian T, Montague, Ian, Frank, Russell J, McCulloh, Carl J, Fichtenbaum, Brad, Lipson, Nashwa, Gabra, Julio A, Ramirez, Christine, Thai, Wairimu, Chege, Margarita M, Gomez Lorenzo, Nirupama, Sista, Jennifer, Farrior, Meredith E, Clement, Elizabeth R, Brown, Kenneth L, Custer, Jacob, Van Naarden, Andrew C, Adams, Andrew E, Schade, Matan C, Dabora, Jack, Knorr, Karen L, Price, Janelle, Sabo, Jay L, Tuttle, Paul, Klekotka, Lei, Shen, Daniel M, Skovronsky, George, Taffet
Publikováno v:
JAMA. 326:46
IMPORTANCE Preventive interventions are needed to protect residents and staff of skilled nursing and assisted living facilities from COVID-19 during outbreaks in their facilities. Bamlanivimab, a neutralizing monoclonal antibody against SARS-CoV-2, m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0258235561f5370f7c10ea27186c4bbf
https://doi.org/10.1001/jama.2021.8828
https://doi.org/10.1001/jama.2021.8828
Autor:
Daniel T. Chiu, Kenneth L. Custer, Peter B. Allen, Naola Austin, Amy L. Nowak, Sandra M. Bajjalieh, Allyson E. Sgro
Publikováno v:
Journal of Neuroscience Methods. 198:230-235
Generating microislands of culture substrate on coverslips by spray application of poly-D lysine is a commonly used method for culturing isolated neurons that form self (autaptic) synapses. This preparation has multiple advantages for studying synapt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5da41d59b76d0b828162788396392b08
https://doi.org/10.1016/j.jneumeth.2011.04.012
https://doi.org/10.1016/j.jneumeth.2011.04.012
Publikováno v:
American Journal of Physiology-Cell Physiology. 299:C960-C967
Among the proteins that mediate calcium-stimulated transmitter release, the synaptic vesicle protein 2 (SV2) stands out as a unique modulator specific to the neurons and endocrine cells of vertebrates. In synapses, SV2 regulates the expression and tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60c586a1bd8bfa03570103509883365e
https://doi.org/10.1152/ajpcell.00259.2010
https://doi.org/10.1152/ajpcell.00259.2010
Autor:
Sandra M. Bajjalieh, Sumiko Mochida, Kenneth L. Custer, Amanda E. Schivell, Patricia Kensel-Hammes
Publikováno v:
Molecular and Cellular Neuroscience. 29:56-64
SV2 (Synaptic Vesicle Protein 2) is expressed in neurons and endocrine cells where it is required for normal calcium-evoked neurosecretion. In mammals, there are three SV2 genes, denoted SV2A, B and C. SV2A interacts with synaptotagmin, the prime can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd61051b2e12a30ad29e00795aa13934
https://doi.org/10.1016/j.mcn.2004.12.011
https://doi.org/10.1016/j.mcn.2004.12.011
Publikováno v:
Trafficking Inside Cells ISBN: 9780387938769
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44f962b1b13e505c8b9230016ef0ec20
https://doi.org/10.1007/978-0-387-93877-6_5
https://doi.org/10.1007/978-0-387-93877-6_5
We report a thorough analysis of neurotransmission in cultured hippocampal neurons lacking synaptic vesicle protein 2 (SV2), a membrane glycoprotein present in all vesicles that undergo regulated secretion. We found that SV2 selectively enhances low-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edcf85862993191523f8929b37310ccf
https://europepmc.org/articles/PMC6674579/
https://europepmc.org/articles/PMC6674579/