Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Kenneth L Scott"'
Autor:
Yiu Huen Tsang, Yumeng Wang, Kathleen Kong, Caitlin Grzeskowiak, Oksana Zagorodna, Turgut Dogruluk, Hengyu Lu, Nicole Villafane, Venkata Hemanjani Bhavana, Daniela Moreno, Sarah H Elsea, Han Liang, Gordon B Mills, Kenneth L Scott
Publikováno v:
eLife, Vol 9 (2020)
The melanoma-associated antigen family A (MAGEA) antigens are expressed in a wide variety of malignant tumors but not in adult somatic cells, rendering them attractive targets for cancer immunotherapy. Here we show that a number of cancer-associated
Externí odkaz:
https://doaj.org/article/b63be19c78e4404ea4ececcfde2c8abb
Autor:
Zixing Wang, Kwok-Shing Ng, Tenghui Chen, Tae-Beom Kim, Fang Wang, Kenna Shaw, Kenneth L Scott, Funda Meric-Bernstam, Gordon B Mills, Ken Chen
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0196939 (2018)
Identification of cancer driver mutations is critical for advancing cancer research and personalized medicine. Due to inter-tumor genetic heterogeneity, many driver mutations occur at low frequencies, which make it challenging to distinguish them fro
Externí odkaz:
https://doaj.org/article/b3bb9085ced6439eb6103ea2d8e82eab
Autor:
Wenyi Zhu, Saritha Krishna, Cristina Garcia, Chia-Ching John Lin, Bartley D Mitchell, Kenneth L Scott, Carrie A Mohila, Chad J Creighton, Seung-Hee Yoo, Hyun Kyoung Lee, Benjamin Deneen
Publikováno v:
eLife, Vol 6 (2017)
Von Hippel-Landau (VHL) protein is a potent tumor suppressor regulating numerous pathways that drive cancer, but mutations in VHL are restricted to limited subsets of malignancies. Here we identified a novel mechanism for VHL suppression in tumors th
Externí odkaz:
https://doaj.org/article/c896bbde90e74bc3b56a52f6fdc76b39
Autor:
Adaobi Mofunanya, Eleanor R. Cameron, Christian J. Braun, Frank Celeste, Xiaoyu Zhao, Michael T. Hemann, Kenneth L. Scott, Jinyu Li, Scott Powers
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract There are hundreds of genes typically overexpressed in breast cancer cells and it's often assumed that their overexpression contributes to cancer progression. However, the precise proportion of these overexpressed genes contributing to tumor
Externí odkaz:
https://doaj.org/article/2e94ab9f512a48898053bbf41470759c
Autor:
Omar Kabbarah, Cristina Nogueira, Bin Feng, Rosalynn M Nazarian, Marcus Bosenberg, Min Wu, Kenneth L Scott, Lawrence N Kwong, Yonghong Xiao, Carlos Cordon-Cardo, Scott R Granter, Sridhar Ramaswamy, Todd Golub, Lyn M Duncan, Stephan N Wagner, Cameron Brennan, Lynda Chin
Publikováno v:
PLoS ONE, Vol 5, Iss 5, p e10770 (2010)
A cardinal feature of malignant melanoma is its metastatic propensity. An incomplete view of the genetic events driving metastatic progression has been a major barrier to rational development of effective therapeutics and prognostic diagnostics for m
Externí odkaz:
https://doaj.org/article/358c6eaf780442aba04e0f86f9f0141b
Autor:
Kwanha, Yu, Kathleen, Kong, Brittney, Lozzi, Estefania, Luna-Figueroa, Alexis, Cervantes, Rachel, Curry, Carrie A, Mohila, Ganesh, Rao, Ali, Jalali, Gordon B, Mills, Kenneth L, Scott, Benjamin, Deneen
Publikováno v:
Neuro-Oncology. 25:471-481
Background Glioblastoma is the most common and aggressive primary brain tumor. Large-scale sequencing initiatives have cataloged its mutational landscape in hopes of elucidating mechanisms driving this deadly disease. However, a major bottleneck in h
Autor:
Rachel Schiff, C. Kent Osborne, Jorge S. Reis-Filho, Britta Weigelt, Joe W. Gray, Mothaffar F. Rimawi, Susan G. Hilsenbeck, Chad A. Shaw, Ben H. Park, Gary C. Chamness, Felipe C. Geyer, Chandandeep Nagi, Carolina Gutierrez, Kenneth L. Scott, Daniel J. Zabransky, Ian Waters, Mahitha Rajendran, Tamika Mitchell, Martin Shea, Sarmistha Nanda, Tao Wang, Alexander Renwick, Edward S. Chen, Charlotte K.Y. Ng, Nicholas Wang, Laura M. Heiser, Vidyalakshmi Sethunath, Jamunarani Veeraraghavan, Lanfang Qin, Huizhong Hu, Agostina Nardone, Kathleen A. Burke, Carmine De Angelis, Xiaowei Xu
Purpose: Resistance to anti-HER2 therapies in HER2+ breast cancer can occur through activation of alternative survival pathways or reactivation of the HER signaling network. Here we employed BT474 parental and treatment-resistant cell line models to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e201b57c505d629e55aa1001b1f5bfb
https://doi.org/10.1158/1078-0432.c.6526164.v1
https://doi.org/10.1158/1078-0432.c.6526164.v1
Autor:
Rachel Schiff, C. Kent Osborne, Jorge S. Reis-Filho, Britta Weigelt, Joe W. Gray, Mothaffar F. Rimawi, Susan G. Hilsenbeck, Chad A. Shaw, Ben H. Park, Gary C. Chamness, Felipe C. Geyer, Chandandeep Nagi, Carolina Gutierrez, Kenneth L. Scott, Daniel J. Zabransky, Ian Waters, Mahitha Rajendran, Tamika Mitchell, Martin Shea, Sarmistha Nanda, Tao Wang, Alexander Renwick, Edward S. Chen, Charlotte K.Y. Ng, Nicholas Wang, Laura M. Heiser, Vidyalakshmi Sethunath, Jamunarani Veeraraghavan, Lanfang Qin, Huizhong Hu, Agostina Nardone, Kathleen A. Burke, Carmine De Angelis, Xiaowei Xu
Supplementary Figures S1-S8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23e427abe7531c4eca4121298b954c95
https://doi.org/10.1158/1078-0432.22465851.v1
https://doi.org/10.1158/1078-0432.22465851.v1
Autor:
Kenneth L. Scott, Raju Kucherlapati, Peter J. Park, Gordon B. Mills, Roel G. Verhaak, Chad J. Creighton, Young Won Kim, Nicholas J. Neill, Lixing Yang, Angeliki Pantazi, Oksana Zagorodna, Yiu Huen Tsang, Kathleen Kong, Caitlin L. Grzeskowiak, Turgut Dogruluk, Nicole Villafane, Hengyu Lu
Oncogenic gene fusions drive many human cancers, but tools to more quickly unravel their functional contributions are needed. Here we describe methodology permitting fusion gene construction for functional evaluation. Using this strategy, we engineer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26651b4976f9547111e4b95287deb941
https://doi.org/10.1158/0008-5472.c.6508520.v1
https://doi.org/10.1158/0008-5472.c.6508520.v1
Autor:
Kenneth L. Scott, Raju Kucherlapati, Peter J. Park, Gordon B. Mills, Roel G. Verhaak, Chad J. Creighton, Young Won Kim, Nicholas J. Neill, Lixing Yang, Angeliki Pantazi, Oksana Zagorodna, Yiu Huen Tsang, Kathleen Kong, Caitlin L. Grzeskowiak, Turgut Dogruluk, Nicole Villafane, Hengyu Lu
Fusion expression detection by PCR (S1); MET fusion expression and signaling activation by immunoblot and N-terminal partner control assay (S2); NTRK2 fusion expression and signaling activation by immunoblot and N-terminal partner control assay (S3);
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e097e94fededb66de3e31490ebf4a668
https://doi.org/10.1158/0008-5472.22412789.v1
https://doi.org/10.1158/0008-5472.22412789.v1