Zobrazeno 1 - 10
of 155
pro vyhledávání: '"Kenneth L Scott"'
Autor:
Adaobi Mofunanya, Eleanor R. Cameron, Christian J. Braun, Frank Celeste, Xiaoyu Zhao, Michael T. Hemann, Kenneth L. Scott, Jinyu Li, Scott Powers
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract There are hundreds of genes typically overexpressed in breast cancer cells and it's often assumed that their overexpression contributes to cancer progression. However, the precise proportion of these overexpressed genes contributing to tumor
Externí odkaz:
https://doaj.org/article/2e94ab9f512a48898053bbf41470759c
Autor:
Xiaohui Hu, Samuel E. Harvey, Rong Zheng, Jingyi Lyu, Caitlin L. Grzeskowiak, Emily Powell, Helen Piwnica-Worms, Kenneth L. Scott, Chonghui Cheng
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Splice isoform switching regulated by the heterogeneous nuclear ribonucleoprotein M (hnRNPM) induces EMT and metastasis. Here, the authors report that AKAP8 is a metastasis suppressor that inhibits the splicing activity of hnRNPM and antagonizes geno
Externí odkaz:
https://doaj.org/article/3e6d53a010c24e5a8bea23bdcf82f99b
Autor:
Carman K. M. Ip, Patrick K. S. Ng, Kang Jin Jeong, S. H. Shao, Zhenlin Ju, P. G. Leonard, Xu Hua, Christopher P. Vellano, Richard Woessner, Nidhi Sahni, Kenneth L. Scott, Gordon B. Mills
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Activation of PDGFRA by genomic aberrations contributes to tumor progression in several tumor types. Here, the authors perform functional characterization of 16 novel PDGFRA mutations identified from different tumor types and demonstrate that a neomo
Externí odkaz:
https://doaj.org/article/5afbb5f4318a4d348864297344880429
Autor:
Yiu Huen Tsang, Yumeng Wang, Kathleen Kong, Caitlin Grzeskowiak, Oksana Zagorodna, Turgut Dogruluk, Hengyu Lu, Nicole Villafane, Venkata Hemanjani Bhavana, Daniela Moreno, Sarah H Elsea, Han Liang, Gordon B Mills, Kenneth L Scott
Publikováno v:
eLife, Vol 9 (2020)
The melanoma-associated antigen family A (MAGEA) antigens are expressed in a wide variety of malignant tumors but not in adult somatic cells, rendering them attractive targets for cancer immunotherapy. Here we show that a number of cancer-associated
Externí odkaz:
https://doaj.org/article/b63be19c78e4404ea4ececcfde2c8abb
Autor:
Minying Zhang, Jens Fritsche, Jason Roszik, Leila J. Williams, Xinxin Peng, Yulun Chiu, Chih-Chiang Tsou, Franziska Hoffgaard, Valentina Goldfinger, Oliver Schoor, Amjad Talukder, Marie A. Forget, Cara Haymaker, Chantale Bernatchez, Leng Han, Yiu-Huen Tsang, Kathleen Kong, Xiaoyan Xu, Kenneth L. Scott, Harpreet Singh-Jasuja, Greg Lizee, Han Liang, Toni Weinschenk, Gordon B. Mills, Patrick Hwu
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
RNA editing is a biological process that creates sequence variation. Here the authors show that peptides generated as a consequence of RNA editing are naturally presented by human leukocyte antigen (HLA) and serve as antigens to elicit anti-tumour im
Externí odkaz:
https://doaj.org/article/2e9bfb402d00408685976df0bcbc9b99
Autor:
Samrat T. Kundu, Caitlin L. Grzeskowiak, Jared J. Fradette, Laura A. Gibson, Leticia B. Rodriguez, Chad J. Creighton, Kenneth L. Scott, Don L. Gibbons
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
One of the major causes of cancer-related mortality is represented by metastatic lung cancer. Here the authors characterize the role of TMEM106B in driving metastatic lung adenocarcinoma and suggest that TMEM106B-mediated secretion of cathespin impac
Externí odkaz:
https://doaj.org/article/3eec8884c2534e3ab8b673a78e5f82ba
Autor:
Caitlin L. Grzeskowiak, Samrat T. Kundu, Xiulei Mo, Andrei A. Ivanov, Oksana Zagorodna, Hengyu Lu, Richard H. Chapple, Yiu Huen Tsang, Daniela Moreno, Maribel Mosqueda, Karina Eterovic, Jared J. Fradette, Sumreen Ahmad, Fengju Chen, Zechen Chong, Ken Chen, Chad J. Creighton, Haian Fu, Gordon B. Mills, Don L. Gibbons, Kenneth L. Scott
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
KRAS-driven lung cancers represent an aggressive form of NSCLC. In this study the authors perform an in vivo functional screening and identify GATAD2B as a driver of tumor growth and metastasis in KRAS-driven lung cancer.
Externí odkaz:
https://doaj.org/article/7d3a32362fb643e9a451c28f602e01e5
Autor:
Kwanha, Yu, Kathleen, Kong, Brittney, Lozzi, Estefania, Luna-Figueroa, Alexis, Cervantes, Rachel, Curry, Carrie A, Mohila, Ganesh, Rao, Ali, Jalali, Gordon B, Mills, Kenneth L, Scott, Benjamin, Deneen
Publikováno v:
Neuro-Oncology. 25:471-481
Background Glioblastoma is the most common and aggressive primary brain tumor. Large-scale sequencing initiatives have cataloged its mutational landscape in hopes of elucidating mechanisms driving this deadly disease. However, a major bottleneck in h
Autor:
Rachel Schiff, C. Kent Osborne, Jorge S. Reis-Filho, Britta Weigelt, Joe W. Gray, Mothaffar F. Rimawi, Susan G. Hilsenbeck, Chad A. Shaw, Ben H. Park, Gary C. Chamness, Felipe C. Geyer, Chandandeep Nagi, Carolina Gutierrez, Kenneth L. Scott, Daniel J. Zabransky, Ian Waters, Mahitha Rajendran, Tamika Mitchell, Martin Shea, Sarmistha Nanda, Tao Wang, Alexander Renwick, Edward S. Chen, Charlotte K.Y. Ng, Nicholas Wang, Laura M. Heiser, Vidyalakshmi Sethunath, Jamunarani Veeraraghavan, Lanfang Qin, Huizhong Hu, Agostina Nardone, Kathleen A. Burke, Carmine De Angelis, Xiaowei Xu
Purpose: Resistance to anti-HER2 therapies in HER2+ breast cancer can occur through activation of alternative survival pathways or reactivation of the HER signaling network. Here we employed BT474 parental and treatment-resistant cell line models to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e201b57c505d629e55aa1001b1f5bfb
https://doi.org/10.1158/1078-0432.c.6526164.v1
https://doi.org/10.1158/1078-0432.c.6526164.v1
Autor:
Rachel Schiff, C. Kent Osborne, Jorge S. Reis-Filho, Britta Weigelt, Joe W. Gray, Mothaffar F. Rimawi, Susan G. Hilsenbeck, Chad A. Shaw, Ben H. Park, Gary C. Chamness, Felipe C. Geyer, Chandandeep Nagi, Carolina Gutierrez, Kenneth L. Scott, Daniel J. Zabransky, Ian Waters, Mahitha Rajendran, Tamika Mitchell, Martin Shea, Sarmistha Nanda, Tao Wang, Alexander Renwick, Edward S. Chen, Charlotte K.Y. Ng, Nicholas Wang, Laura M. Heiser, Vidyalakshmi Sethunath, Jamunarani Veeraraghavan, Lanfang Qin, Huizhong Hu, Agostina Nardone, Kathleen A. Burke, Carmine De Angelis, Xiaowei Xu
Supplementary Figures S1-S8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23e427abe7531c4eca4121298b954c95
https://doi.org/10.1158/1078-0432.22465851.v1
https://doi.org/10.1158/1078-0432.22465851.v1