Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Kenneth L Madsen"'
Autor:
Nikolaj R Christensen, Marta De Luca, Michael B Lever, Mette Richner, Astrid B Hansen, Gith Noes‐Holt, Kathrine L Jensen, Mette Rathje, Dennis Bo Jensen, Simon Erlendsson, Christian RO Bartling, Ina Ammendrup‐Johnsen, Sofie E Pedersen, Michèle Schönauer, Klaus B Nissen, Søren R Midtgaard, Kaare Teilum, Lise Arleth, Andreas T Sørensen, Anders Bach, Kristian Strømgaard, Claire F Meehan, Christian B Vægter, Ulrik Gether, Kenneth L Madsen
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 6, Pp n/a-n/a (2020)
Abstract Maladaptive plasticity involving increased expression of AMPA‐type glutamate receptors is involved in several pathologies, including neuropathic pain, but direct inhibition of AMPARs is associated with side effects. As an alternative, we d
Externí odkaz:
https://doaj.org/article/8a1820f6df8d4578a98d525b18b57606
Autor:
Birgitte Holst, Kenneth L Madsen, Anna M Jansen, Chunyu Jin, Mattias Rickhag, Viktor K Lund, Morten Jensen, Vikram Bhatia, Gunnar Sørensen, Andreas N Madsen, Zhichao Xue, Siri K Møller, David Woldbye, Klaus Qvortrup, Richard Huganir, Dimitrios Stamou, Ole Kjærulff, Ulrik Gether
Publikováno v:
PLoS Biology, Vol 11, Iss 4, p e1001542 (2013)
Secretory vesicles in endocrine cells store hormones such as growth hormone (GH) and insulin before their release into the bloodstream. The molecular mechanisms governing budding of immature secretory vesicles from the trans-Golgi network (TGN) and t
Externí odkaz:
https://doaj.org/article/1b1e37beba824678913f7f38cf8eb86b
Autor:
Marie Balslev Backe, Rita Chan Andersen, Morten Jensen, Chunyu Jin, Cecilie Hundahl, Oksana Dmytriyeva, Jonas T Treebak, Jakob Bondo Hansen, Zach Gerhart-Hines, Kenneth L Madsen, Birgitte Holst
Publikováno v:
Backe, M B, Andersen, R C, Jensen, M, Jin, C, Hundahl, C, Dmytriyeva, O, Treebak, J T, Hansen, J B, Gerhart-hines, Z, Madsen, K L & Holst, B 2023, ' PICK1-Deficient Mice Maintain Their Glucose Tolerance During Diet-Induced Obesity ', Journal of the endocrine society, vol. 7, no. 6 . https://doi.org/10.1210/jendso/bvad057
Context Metabolic disorders such as obesity represent a major health challenge. Obesity alone has reached epidemic proportions, with at least 2.8 million people worldwide dying annually from diseases caused by overweight or obesity. The brain–metab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34b9f16224f9d15e5962dd0686887a99
https://curis.ku.dk/ws/files/356506211/bvad057.pdf
https://curis.ku.dk/ws/files/356506211/bvad057.pdf
Autor:
Søren H. Jørgensen, Aske L. Ejdrup, Matthew D. Lycas, Leonie P. Posselt, Kenneth L. Madsen, Lin Tian, Jakob K. Dreyer, Freja Herborg, Andreas T. Sørensen, Ulrik Gether
Publikováno v:
Jørgensen, S H, Ejdrup, A L, Lycas, M D, Posselt, L P, Madsen, K L, Tian, L, Dreyer, J K, Herborg, F, Sørensen, A T & Gether, U 2023, ' Behavioral encoding across timescales by region-specific dopamine dynamics ', Proceedings of the National Academy of Sciences of the United States of America, vol. 120, no. 7, e2215230120 . https://doi.org/10.1073/pnas.2215230120
The dorsal (DS) and ventral striatum (VS) receive dopaminergic projections that control motor functions and reward-related behavior. It remains poorly understood how dopa-mine release dynamics across different temporal scales in these regions are cou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99b4413269dc6b326372ea08486dc19a
https://curis.ku.dk/ws/files/336255717/Fulltext.pdf
https://curis.ku.dk/ws/files/336255717/Fulltext.pdf
Publikováno v:
Methods in Molecular Biology ISBN: 9781071625965
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35bd756f7eaba54bd32fbfda27f0093a
https://doi.org/10.1007/978-1-0716-2597-2_22
https://doi.org/10.1007/978-1-0716-2597-2_22
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2551
Protein aggregates, hereunder amyloid fibrils, can undergo a maturation process, whereby early formed aggregates undergo a structural and physicochemical transition leading to more mature species. In the case of amyloid-related diseases, such maturat
Autor:
Aske L. Ejdrup, Matthew D. Lycas, Niels Lorenzen, Ainoa Konomi, Freja Herborg, Kenneth L. Madsen, Ulrik Gether
Publikováno v:
Ejdrup, A L, Lycas, M D, Lorenzen, N, Konomi, A, Herborg, F, Madsen, K L & Gether, U 2022, ' A density-based enrichment measure for assessing colocalization in single-molecule localization microscopy data ', Nature Communications, vol. 13, no. 1, 4388 . https://doi.org/10.1038/s41467-022-32064-y
Dual-color single-molecule localization microscopy (SMLM) provides unprecedented possibilities for detailed studies of colocalization of different molecular species in a cell. However, the informational richness of the data is not fully exploited by
Autor:
Rita C. Andersen, Jan H. Schmidt, Joscha Rombach, Matthew D. Lycas, Nikolaj R. Christensen, Viktor K. Lund, Donnie S. Stapleton, Signe S. Pedersen, Mathias A. Olsen, Mikkel Stoklund, Gith Noes-Holt, Tommas T.E. Nielsen, Mark P. Keller, Anna M. Jansen, Rasmus Herlo, Massimo Pietropaolo, Jens B. Simonsen, Ole Kjærulff, Birgitte Holst, Alan D. Attie, Ulrik Gether, Kenneth L. Madsen
Publikováno v:
Andersen, R C, Schmidt, J H, Rombach, J, Lycas, M D, Christensen, N R, Lund, V K, Stapleton, D S, Pedersen, S S, Olsen, M A, Stoklund, M, Noes-Holt, G, Nielsen, T T E, Keller, M P, Jansen, A M, Herlo, R, Pietropaolo, M, Simonsen, J B, Kjærulff, O, Holst, B, Attie, A D, Gether, U & Madsen, K L 2022, ' Coding variants identified in patients with diabetes alter PICK1 BAR domain function in insulin granule biogenesis ', Journal of Clinical Investigation, vol. 132, no. 5, e144904 . https://doi.org/10.1172/JCI144904
Bin/amphiphysin/Rvs (BAR) domains are positively charged crescent-shaped modules that mediate curvature of negatively charged lipid membranes during remodeling processes. The BAR domain proteins PICK1, ICA69, and the arfaptins have recently been demo
Autor:
Aske L. Ejdrup, Matthew D. Lycas, Niels Lorenzen, Ainoa Konomi, Freja Herborg, Kenneth L. Madsen, Ulrik Gether
Dual-color single-molecule localization microscopy (SMLM) provides unprecedented possibilities for detailed studies of colocalization of different molecular species in a cell. However, the informational richness of the data is not fully exploited by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::768bb6c4588ae69bd83f4b2a10f9a52a
https://doi.org/10.1101/2022.02.08.479535
https://doi.org/10.1101/2022.02.08.479535
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Skamris, T, Marasini, C, Madsen, K L, Foderà, V & Vestergaard, B 2019, ' Early Stage Alpha-Synuclein Amyloid Fibrils are Reservoirs of Membrane-Binding Species ', Scientific Reports, vol. 9, 1733, pp. 1-11 . https://doi.org/10.1038/s41598-018-38271-2
Scientific Reports
Skamris, T, Marasini, C, Madsen, K L, Foderà, V & Vestergaard, B 2019, ' Early Stage Alpha-Synuclein Amyloid Fibrils are Reservoirs of Membrane-Binding Species ', Scientific Reports, vol. 9, 1733, pp. 1-11 . https://doi.org/10.1038/s41598-018-38271-2
The presence of αSN fibrils indisputably associates with the development of synucleinopathies. However, while certain fibril morphologies have been linked to downstream pathological phenotypes, others appear less harmful, leading to the concept of f