Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Kenneth L Dretchen"'
Autor:
Niaz Sahibzada, Allen W Mangel, Jaclyn E Tatge, Kenneth L Dretchen, Michael R Franz, Renu Virmani, Richard A Gillis
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0130255 (2015)
For over a century, the behavior of the aorta and other large arteries has been described as passive elastic tubes in which no active contraction occurs in the smooth muscle wall. In response to pulsatile pressure changes, the vessels undergo a 'pass
Externí odkaz:
https://doaj.org/article/705598c356384089b7d4ceac73bf714a
Autor:
David A. Dworaczyk, PhD, Allen L. Hunt, MD, Mike Di Spirito, MSc, Mary Lor, BSc, GrDip, Kenneth L. Dretchen, PhD, Michael J. Lamson, PhD, Jonathan Pollock, MSci, Thelma Ward, PhD
Publikováno v:
Journal of Allergy and Clinical Immunology: Global, Vol 3, Iss 2, Pp 100200- (2024)
Background: Recent acute anaphylaxis guideline updates have identified remaining unmet needs based on currently available therapeutic options as a critical focus. Objective: We compared the pharmacokinetic, pharmacodynamic, safety, and tolerability p
Externí odkaz:
https://doaj.org/article/2a2ab5a5ea6049e09fa365f1fd167b13
Autor:
Richard Tuttle, Luca Popescu, Scott Hill, Amber Slanczka, Jeffrey Jankowski, Katherine Barre, Erika Krueger, Desmond Slade, Claire Croutch, Matthew Robben, Zack Mesa, Michael Mesa, Kenneth L. Dretchen
Publikováno v:
Respiratory Research, Vol 21, Iss 1, Pp 1-7 (2020)
Abstract Background Histamine release and vasodilation during an allergic reaction can alter the pharmacokinetics of drugs administered via the intranasal (IN) route. The current study evaluated the effects of histamine-induced nasal congestion on ep
Externí odkaz:
https://doaj.org/article/346e71df9ee640aba0214967e6a3534e
Autor:
Kenneth L. Dretchen, Zack Mesa, Matthew Robben, Desmond Slade, Scott Hill, Claire Croutch, Kyle Kappeler, Michael Mesa
Publikováno v:
Pharmacology Research & Perspectives, Vol 8, Iss 2, Pp n/a-n/a (2020)
Abstract Epinephrine is the standard of care for the treatment of severe allergy and anaphylaxis. Epinephrine is most often administered through the intramuscular (IM) route via autoinjector. The current study aimed to evaluate an alternative method
Externí odkaz:
https://doaj.org/article/3d271e383d4d4f32b1f72a05282d685d
Publikováno v:
Therapeutic Advances in Allergy and Rhinology. 14:275340302311617
Background Despite epinephrine's historical use for over a century and Food and Drug Administration (FDA) approval for EpiPen's use in 1987 to treat anaphylaxis, little information exists regarding selection of the 0.3 mg adult dose. A review of lite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c4541d68f40ee952ff1636314c361f0
https://doi.org/10.1177/27534030231161784
https://doi.org/10.1177/27534030231161784
Autor:
Michael Mesa, Desmond Slade, Matthew P. Robben, Kenneth L. Dretchen, Claire R. Croutch, Zack Mesa, Scott Hill, Kara Forsee
Publikováno v:
Pharmaceutical Research. 37
We aimed to assess intranasal (IN) epinephrine effects on cerebrospinal fluid (CSF) absorption, nasal mucosa quality, plasma epinephrine pharmacokinetics (PK), and cardiovascular changes in dogs. CSF epinephrine concentration was measured and nasal m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::646135bb4152566327c4f8afbb1b9d8a
https://doi.org/10.1007/s11095-020-02829-5
https://doi.org/10.1007/s11095-020-02829-5
Autor:
Scott Hill, Michael Mesa, Desmond Slade, Zack Mesa, Matthew P. Robben, Kyle Kappeler, Kenneth L. Dretchen, Claire R. Croutch
Publikováno v:
Pharmacology Research & Perspectives, Vol 8, Iss 2, Pp n/a-n/a (2020)
Pharmacology Research & Perspectives
Pharmacology Research & Perspectives
Epinephrine is the standard of care for the treatment of severe allergy and anaphylaxis. Epinephrine is most often administered through the intramuscular (IM) route via autoinjector. The current study aimed to evaluate an alternative method of epinep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e7922c017e2f5e6f352b742ef804eaf
https://doaj.org/article/3d271e383d4d4f32b1f72a05282d685d
https://doaj.org/article/3d271e383d4d4f32b1f72a05282d685d
Autor:
Ghazaul Dezfuli, Kenneth L. Dretchen, Yousef Tizabi, Niaz Sahibzada, Kenneth J. Kellar, Richard A. Gillis
Publikováno v:
Neuropharmacology. 110:165-174
Nicotine's effect on food intake and body weight has been well documented; however, the relevant receptors underlying these effects have not been firmly established. The purpose of the present study was to: (1) identify the nicotinic acetylcholine re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f7d62517573c0cc51e6dc13dcadb4da
https://doi.org/10.1016/j.neuropharm.2016.07.020
https://doi.org/10.1016/j.neuropharm.2016.07.020
Autor:
Richard A. Gillis, Niaz Sahibzada, Stefano Vicini, Amanda E. Lewin, Kenneth L. Dretchen, Janell Richardson
Publikováno v:
The Journal of Physiology. 594:2661-2679
Key points The dorsal motor nucleus of the vagus (DMV) in the brainstem consists primarily of vagal preganglionic neurons that innervate postganglionic neurons of the upper gastrointestinal tract. The activity of the vagal preganglionic neurons is pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cf81f03458ba7b51df9762021af1a33
https://doi.org/10.1113/jp272069
https://doi.org/10.1113/jp272069
Autor:
Joseph G. Verbalis, Kenneth L. Dretchen, Kimbell R Duncan, Richard A. Gillis, Jaclyn E. Tatge, Niaz Sahibzada, Ghazaul Dezfuli, Patrick G. Jackson
Publikováno v:
Frontiers in Neuroscience, Vol 12 (2018)
Frontiers in Neuroscience
Frontiers in Neuroscience
Background/Objectives: We tested the hypothesis that abolishing vagal nerve activity will reverse the obesity phenotype of melanocortin 4 receptor knockout mice (Mc4r-/-). Subjects/Methods: In two separate studies, we examined the efficacy of bilater
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87e0a7a755a623efcd69730c4af17ead
http://journal.frontiersin.org/article/10.3389/fnins.2018.00104/full
http://journal.frontiersin.org/article/10.3389/fnins.2018.00104/full