Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Kenneth L, Granberg"'
Autor:
Laura A. Woo, Kaitlyn L. Wintruba, Bethany Wissmann, Svyatoslav Tkachenko, Ewa Kubicka, Emily Farber, Ola Engkvist, Ian Barrett, Kenneth L. Granberg, Alleyn T. Plowright, Matthew J. Wolf, David L. Brautigan, Stefan Bekiranov, Qing-Dong Wang, Jeffrey J. Saucerman
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110485- (2024)
Summary: Mammalian hearts lose their regenerative potential shortly after birth. Stimulating the proliferation of preexisting cardiomyocytes is a potential therapeutic strategy for cardiac damage. In a previous study, we identified 30 compounds that
Externí odkaz:
https://doaj.org/article/1bf1716420a649368af21109efc59278
The allosterically modulated FFAR2 is transactivated by signals generated by other neutrophil GPCRs.
Publikováno v:
PLoS ONE, Vol 18, Iss 4, p e0268363 (2023)
Positive allosteric modulators for free fatty acid receptor 2 (FFAR2/GPR43), that affect receptor function through binding to two distinct allosteric binding sites, were used to determine the correlation between the responses induced in neutrophils b
Externí odkaz:
https://doaj.org/article/241c0548754644a7b97e5884e5b092c7
Autor:
Krister Bamberg, Ulrika Johansson, Karl Edman, Lena William-Olsson, Susanna Myhre, Anders Gunnarsson, Stefan Geschwindner, Anna Aagaard, Anna Björnson Granqvist, Frédéric Jaisser, Yufeng Huang, Kenneth L Granberg, Rasmus Jansson-Löfmark, Judith Hartleib-Geschwindner
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0193380 (2018)
Excess mineralocorticoid receptor (MR) activation promotes target organ dysfunction, vascular injury and fibrosis. MR antagonists like eplerenone are used for treating heart failure, but their use is limited due to the compound class-inherent hyperka
Externí odkaz:
https://doaj.org/article/837696cf2e364f56bb14da55aad00b11
Autor:
Huamei Forsman, Yanling Wu, Jonas Mårtensson, Lena Björkman, Kenneth L. Granberg, Claes Dahlgren, Martina Sundqvist
Publikováno v:
Biochemical Pharmacology. 211:115529
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3635feb798f9a72a64dae3cb1bbd09a9
https://doi.org/10.1016/j.bcp.2023.115529
https://doi.org/10.1016/j.bcp.2023.115529
Positive allosteric modulators for free fatty acid receptor 2 (FFA2R/GPR43), that affect receptor function through binding to two distinct allosteric binding sites, were used to determine the correlation between the responses induced in neutrophils b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81fd51eab393900bdb419e25904b00a2
https://doi.org/10.1101/2022.04.29.489985
https://doi.org/10.1101/2022.04.29.489985
Autor:
Kenneth L. Granberg, Zhong-Qing Yuan, Bo Lindmark, Karl Edman, Johan Kajanus, Anders Hogner, Marcus Malmgren, Gavin O’Mahony, Anneli Nordqvist, Jan Lindberg, Stefan Tångefjord, Michael Kossenjans, Christian Löfberg, Jonas Brånalt, Dongmei Liu, Nidhal Selmi, Grigorios Nikitidis, Peter Nordberg, Ahlke Hayen, Anna Aagaard, Eva Hansson, Majlis Hermansson, Ida Ivarsson, Rasmus Jansson-Löfmark, Ulla Karlsson, Ulrika Johansson, Lena William-Olsson, Judith Hartleib-Geschwindner, Krister Bamberg
Publikováno v:
Journal of Medicinal Chemistry. 62:1385-1406
The mechanism-based risk for hyperkalemia has limited the use of mineralocorticoid receptor antagonists (MRAs) like eplerenone in cardio-renal diseases. Here, we describe the structure and property-driven lead generation and optimization, which resul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0f3415ae30a4bd17f715f083a4fc37e
https://doi.org/10.1021/acs.jmedchem.8b01523
https://doi.org/10.1021/acs.jmedchem.8b01523
Autor:
Anneli, Nordqvist, Kenneth L, Granberg
Publikováno v:
Vitamins and hormones. 109
Two mineralocorticoid receptor antagonists, spironolactone and eplerenone, are currently approved by the FDA. Several non-steroid based ligands are in clinical trials for indications including heart failure, hypertension and diabetic kidney disease,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2edd9495c2ca02d8edb0756e0470c413
https://pubmed.ncbi.nlm.nih.gov/30678854
https://pubmed.ncbi.nlm.nih.gov/30678854
Publikováno v:
Tetrahedron Letters. 40:755-758
The intermediates 3 and 4 , useful in the preparation of new biologically active bafilomycin derivatives, were obtained via a thermal retro-aldol reaction in diphenyl ether. The starting materials 5 and 7 for the retro-aldol reaction were synthesized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a538b99d4ee5a2c70860a1d04c7bb9c
https://doi.org/10.1016/s0040-4039(98)02365-x
https://doi.org/10.1016/s0040-4039(98)02365-x
Publikováno v:
Tetrahedron Letters. 37:9001-9004
Treatment of bafilomycin A 1 and isobafilomycin A 1 with triphenylphosphine and diethylazodicarboxylate under Mitsunobu conditions led to a fragmentation of the sugar-like ring to give the corresponding olefinic ester. The structure of the product fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac0989b8275da469e20a6686e0d279be
https://doi.org/10.1016/s0040-4039(96)02113-2
https://doi.org/10.1016/s0040-4039(96)02113-2
Autor:
Jan-E. Bäckvall, Kenneth L. Granberg
Publikováno v:
Journal of the American Chemical Society. 114:6858-6863
Treatment of (π-allyl)palladium complexes such as 6 and 9 with Pd(PPh 3 ) 4 leads to rapid isomerization at -15 o C in tetrahydrofuran and other solvents. At 0 o C and in the presence of more than 2 equiv of triphenylphosphine per palladium, the pho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26c7b698fc47ec3af4fea0e7979ae05d
https://doi.org/10.1021/ja00043a034
https://doi.org/10.1021/ja00043a034