Coffee and energy drink use patterns in college freshmen: associations with adverse health behaviors and risk factors

Autor: Dace S. Svikis, Pamela M. Dillon, Steven E. Meredith, Leroy R. Thacker, Kathryn Polak, Alexis C. Edwards, David Pomm, Danielle Dick, Kenneth Kendler, Spit for Science Working Group

Publikováno v: BMC Public Health, Vol 22, Iss 1, Pp 1-10 (2022)

Abstract Background Public health concern over college students mixing caffeine-containing energy drinks (EDs) and alcohol has contributed to an array of ED-focused research studies. One review found consistent associations between ED use and heavy/p

Externí odkaz: https://doaj.org/article/f420ce5559a24342bb4fe326ca1cf4b6

Polygenic analyses show important differences between MDD symptoms collected using PHQ9 and CIDI-SF

Autor: Lianyun Huang, Sonja Tang, Jolien Rietkerk, Vivek Appadurai, Morten Dybdahl Krebs, Andrew J. Schork, Thomas Werge, Verena Zuber, Kenneth Kendler, Na Cai

Symptoms of Major Depressive Disorder (MDD) are commonly assessed using self-rating instruments like the Patient Health Questionnaire 9 (PHQ9, for current symptoms), and the Composite International Diagnostic Interview Short-Form (CIDI-SF, for lifeti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::93343a2265c5618b5057501f32ba0a31
https://doi.org/10.1101/2023.02.27.23286527

Phenotype integration improves power and preserves specificity in biobank-based genetic studies of MDD

Autor: Andrew Dahl, Michael Thompson, Ulzee An, Morten Krebs, Vivek Appadurai, Richard Border, Silviu-Alin Bacanu, Thomas Werge, Jonathan Flint, Andrew J. Schork, Sriram Sankararaman, Kenneth Kendler, Na Cai

Biobanks often contain several phenotypes relevant to a given disorder, and researchers face complex tradeoffs between shallow phenotypes (high sample size, low specificity and sensitivity) and deep phenotypes (low sample size, high specificity and s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3fc321326b3a46d768b9ec5c530a67aa
https://doi.org/10.1101/2022.08.15.503980

A large-scale genome-wide association study meta-analysis of cannabis use disorder

Autor: Emma C Johnson, Ditte Demontis, Thorgeir E Thorgeirsson, Raymond K Walters, Renato Polimanti, Alexander S Hatoum, Sandra Sanchez-Roige, Sarah E Paul, Frank R Wendt, Toni-Kim Clarke, Dongbing Lai, Gunnar W Reginsson, Hang Zhou, June He, David A A Baranger, Daniel F Gudbjartsson, Robbee Wedow, Daniel E Adkins, Amy E Adkins, Jeffry Alexander, Silviu-Alin Bacanu, Tim B Bigdeli, Joseph Boden, Sandra A Brown, Kathleen K Bucholz, Jonas Bybjerg-Grauholm, Robin P Corley, Louisa Degenhardt, Danielle M Dick, Benjamin W Domingue, Louis Fox, Alison M Goate, Scott D Gordon, Laura M Hack, Dana B Hancock, Sarah M Hartz, Ian B Hickie, David M Hougaard, Kenneth Krauter, Penelope A Lind, Jeanette N McClintick, Matthew B McQueen, Jacquelyn L Meyers, Grant W Montgomery, Ole Mors, Preben B Mortensen, Merete Nordentoft, John F Pearson, Roseann E Peterson, Maureen D Reynolds, John P Rice, Valgerdur Runarsdottir, Nancy L Saccone, Richard Sherva, Judy L Silberg, Ralph E Tarter, Thorarinn Tyrfingsson, Tamara L Wall, Bradley T Webb, Thomas Werge, Leah Wetherill, Margaret J Wright, Stephanie Zellers, Mark J Adams, Laura J Bierut, Jason D Boardman, William E Copeland, Lindsay A Farrer, Tatiana M Foroud, Nathan A Gillespie, Richard A Grucza, Kathleen Mullan Harris, Andrew C Heath, Victor Hesselbrock, John K Hewitt, Christian J Hopfer, John Horwood, William G Iacono, Eric O Johnson, Kenneth S Kendler, Martin A Kennedy, Henry R Kranzler, Pamela A F Madden, Hermine H Maes, Brion S Maher, Nicholas G Martin, Matthew McGue, Andrew M McIntosh, Sarah E Medland, Elliot C Nelson, Bernice Porjesz, Brien P Riley, Michael C Stallings, Michael M Vanyukov, Scott Vrieze, Lea K Davis, Ryan Bogdan, Joel Gelernter, Howard J Edenberg, Kari Stefansson, Anders D Børglum, Arpana Agrawal, Raymond Walters, Emma Johnson, Jeanette McClintick, Alexander Hatoum, Frank Wendt, Mark Adams, Amy Adkins, Fazil Aliev, Anthony Batzler, Sarah Bertelsen, Joanna Biernacka, Tim Bigdeli, Li-Shiun Chen, Yi-Ling Chou, Franziska Degenhardt, Anna Docherty, Alexis Edwards, Pierre Fontanillas, Jerome Foo, Josef Frank, Ina Giegling, Scott Gordon, Laura Hack, Annette Hartmann, Sarah Hartz, Stefanie Heilmann-Heimbach, Stefan Herms, Colin Hodgkinson, Per Hoffman, Jouke Hottenga, Martin Kennedy, Mervi Alanne-Kinnunen, Bettina Konte, Jari Lahti, Marius Lahti-Pulkkinen, Lannie Ligthart, Anu Loukola, Brion Maher, Hamdi Mbarek, Andrew McIntosh, Matthew McQueen, Jacquelyn Meyers, Yuri Milaneschi, Teemu Palviainen, John Pearson, Roseann Peterson, Samuli Ripatti, Euijung Ryu, Nancy Saccone, Jessica Salvatore, Melanie Schwandt, Fabian Streit, Jana Strohmaier, Nathaniel Thomas, Jen-Chyong Wang, Bradley Webb, Amanda Wills, Jason Boardman, Danfeng Chen, Doo-Sup Choi, William Copeland, Robert Culverhouse, Norbert Dahmen, Benjamin Domingue, Sarah Elson, Mark Frye, Wolfgang Gäbel, Caroline Hayward, Marcus Ising, Margaret Keyes, Falk Kiefer, John Kramer, Samuel Kuperman, Susanne Lucae, Michael Lynskey, Wolfgang Maier, Karl Mann, Satu Männistö, Bertram Müller-Myhsok, Alison Murray, John Nurnberger, Aarno Palotie, Ulrich Preuss, Katri Räikkönen, Maureen Reynolds, Monika Ridinger, Norbert Scherbaum, Marc Schuckit, Michael Soyka, Jens Treutlein, Stephanie Witt, Norbert Wodarz, Peter Zill, Daniel Adkins, Dorret Boomsma, Laura Bierut, Sandra Brown, Kathleen Bucholz, Sven Cichon, E. Jane Costello, Harriet de Wit, Nancy Diazgranados, Danielle Dick, Johan Eriksson, Lindsay Farrer, Tatiana Foroud, Nathan Gillespie, Alison Goate, David Goldman, Richard Grucza, Dana Hancock, Andrew Heath, John Hewitt, Christian Hopfer, William Iacono, Eric Johnson, Jaakko Kaprio, Victor Karpyak, Kenneth Kendler, Henry Kranzler, Paul Lichtenstein, Penelope Lind, Matt McGue, James MacKillop, Pamela Madden, Hermine Maes, Patrik Magnusson, Nicholas Martin, Sarah Medland, Grant Montgomery, Elliot Nelson, Markus Nöthen, Abraham Palmer, Nancy Pederson, Brenda Penninx, John Rice, Marcella Rietschel, Brien Riley, Richard Rose, Dan Rujescu, Pei-Hong Shen, Judy Silberg, Michael Stallings, Ralph Tarter, Michael Vanyukov, Tamara Wall, John Whitfield, Hongyu Zhao, Benjamin Neale, Howard Edenberg

Publikováno v: Johnson, E, Hottenga, J, Ligthart, L, Mbarek, H, Milaneschi, Y, Boomsma, D, Agrawal, A & Psychiatric Genomics Consortium Substance Use Disorders Workgroup 2020, ' A large-scale genome-wide association study meta-analysis of cannabis use disorder ', The Lancet Psychiatry, vol. 7, no. 12, pp. 1032-1045 . https://doi.org/10.1016/S2215-0366(20)30339-4
Johnson, E C, Demontis, D, Thorgeirsson, T E, Walters, R K, Polimanti, R, Hatoum, A S, Sanchez-Roige, S, Paul, S E, Wendt, F R, Clarke, T-K, Lai, D, Reginsson, G W, Zhou, H, He, J, Baranger, D A A, Gudbjartsson, D F, Wedow, R, Adkins, D E, Adkins, A E, Alexander, J, Bacanu, S-A, Bigdeli, T B, Boden, J, Brown, S A, Bucholz, K K, Bybjerg-Grauholm, J, Corley, R P, Degenhardt, L, Dick, D M, Domingue, B W, Fox, L, Goate, A M, Gordon, S D, Hack, L M, Hancock, D B, Hartz, S M, Hickie, I B, Hougaard, D M, Krauter, K, Lind, P A, McClintick, J N, McQueen, M B, Meyers, J L, Montgomery, G W, Mors, O, Mortensen, P B, Nordentoft, M, Pearson, J F, Peterson, R E, Børglum, A D & Psychiatric Genomics Consortium Substance Use Disorders Workgroup 2020, ' A large-scale genome-wide association study meta-analysis of cannabis use disorder ', The Lancet Psychiatry, vol. 7, no. 12, pp. 1032-1045 . https://doi.org/10.1016/S2215-0366(20)30339-4
The Lancet Psychiatry, 7(12), 1032-1045. Elsevier Limited
The Lancet. Psychiatry
Johnson, E C, Demontis, D, Thorgeirsson, T E, Walters, R, Polimanti, R, Hatoum, A S, Sanchez-roige, S, Paul, S E, Wendt, F R, Clarke, T, Lai, D, Reginsson, G W, Zhou, H, He, J, Baranger, D A A, Gudbjartsson, D F, Wedow, R, Adkins, D, Adkins, A, Alexander, J, Bacanu, S, Bigdeli, T B, Boden, J, Brown, S A, Bucholz, K, Bybjerg-grauholm, J, Corley, R P, Degenhardt, L, Dick, D, Domingue, B, Fox, L, Goate, A M, Gordon, S, Hack, L, Hancock, D, Hartz, S, Hickie, I B, Hougaard, D M, Krauter, K, Lind, P, Mcclintick, J, Mcqueen, M, Meyers, J, Montgomery, G, Mors, O, Mortensen, P B, Nordentoft, M, Pearson, J F, Peterson, R, Reynolds, M, Rice, J, Runarsdottir, V, Saccone, N, Sherva, R, Silberg, J L, Tarter, R, Tyrfingsson, T, Wall, T, Webb, B, Werge, T, Wetherill, L, Wright, M J, Zellers, S, Adams, M J, Bierut, L, Boardman, J, Copeland, W, Farrer, L, Foroud, T M, Gillespie, N A, Grucza, R A, Harris, K M, Heath, A, Hesselbrock, V, Hewitt, J, Hopfer, C, Horwood, J, Iacono, W G, Johnson, E, Kendler, K, Kennedy, M, Kranzler, H, Madden, P A F, Maes, H, Maher, B, Martin, N G, Mcgue, M, Mcintosh, A M, Medland, S, Nelson, E C, Porjesz, B, Riley, B, Stallings, M, Vanyukov, M, Vrieze, S, Davis, L K, Bogdan, R, Gelernter, J, Edenberg, H, Stefansson, K, Børglum, A D, Agrawal, A, Walters, R, Polimanti, R, Johnson, E, Mcclintick, J, Hatoum, A, He, J, Wendt, F, Zhou, H, Adkins, A, Aliev, F, Bacanu, S, Batzler, A, Bertelsen, S, Biernacka, J, Bigdeli, T, Chen, L, Clarke, T, Chou, Y, Degenhardt, F, Docherty, A, Edwards, A, Fontanillas, P, Foo, J, Fox, L, Frank, J, Giegling, I, Gordon, S, Hack, L, Hartmann, A, Hartz, S, Heilmann-heimbach, S, Herms, S, Hodgkinson, C, Hoffman, P, Hottenga, J, Kennedy, M, Alanne-kinnunen, M, Konte, B, Lahti, J, Lahti-pulkkinen, M, Lai, D, Ligthart, L, Loukola, A, Maher, B, Mbarek, H, Mcintosh, A M, Mcqueen, M, Meyers, J, Milaneschi, Y, Palviainen, T, Pearson, J, Peterson, R, Ripatti, S, Ryu, E, Saccone, N, Salvatore, J, Sanchez-roige, S, Schwandt, M, Sherva, R, Streit, F, Strohmaier, J, Thomas, N, Wang, J, Webb, B, Wedow, R, Wetherill, L, Wills, A, Boardman, J, Chen, D, Choi, D, Copeland, W, Culverhouse, R, Dahmen, N, Degenhardt, L, Domingue, B, Elson, S, Frye, M, Gäbel, W, Hayward, C, Ising, M, Keyes, M, Kiefer, F, Kramer, J, Kuperman, S, Lucae, S, Lynskey, M, Maier, W, Mann, K, Männistö, S, Müller-myhsok, B, Murray, A, Nurnberger, J, Palotie, A, Preuss, U, Räikkönen, K, Reynolds, M, Ridinger, M, Scherbaum, N, Schuckit, M, Soyka, M, Treutlein, J, Witt, S, Wodarz, N, Zill, P, Adkins, D, Boden, J, Boomsma, D, Bierut, L, Brown, S, Bucholz, K, Cichon, S, Costello, E J, De Wit, H, Diazgranados, N, Dick, D, Eriksson, J, Farrer, L, Foroud, T, Gillespie, N, Goate, A, Goldman, D, Grucza, R, Hancock, D, Harris, K M, Heath, A, Hesselbrock, V, Hewitt, J, Hopfer, C, Horwood, J, Iacono, W, Johnson, E, Kaprio, J, Karpyak, V, Kendler, K, Kranzler, H, Krauter, K, Lichtenstein, P, Lind, P, Mcgue, M, Mackillop, J, Madden, P, Maes, H, Magnusson, P, Martin, N, Medland, S, Montgomery, G, Nelson, E, Nöthen, M, Palmer, A, Pederson, N, Penninx, B, Porjesz, B, Rice, J, Rietschel, M, Riley, B, Rose, R, Rujescu, D, Shen, P, Silberg, J, Stallings, M, Tarter, R, Vanyukov, M, Vrieze, S, Wall, T, Whitfield, J, Zhao, H, Neale, B, Gelernter, J, Edenberg, H & Agrawal, A 2020, ' A large-scale genome-wide association study meta-analysis of cannabis use disorder ', The Lancet Psychiatry, vol. 7, no. 12, pp. 1032-1045 . https://doi.org/10.1016/S2215-0366(20)30339-4
Johnson, E C, Demontis, D, Thorgeirsson, T E, Walters, R K, Polimanti, R, Hatoum, A S, Sanchez-Roige, S, Paul, S E, Wendt, F R, Clarke, T K, Lai, D, Reginsson, G W, Zhou, H, He, J, Baranger, D A A, Gudbjartsson, D F, Wedow, R, Adkins, D E, Adkins, A E, Alexander, J, Bacanu, S A, Bigdeli, T B, Boden, J, Brown, S A, Bucholz, K K, Bybjerg-Grauholm, J, Corley, R P, Degenhardt, L, Dick, D M, Domingue, B W, Fox, L, Goate, A M, Gordon, S D, Hack, L M, Hancock, D B, Hartz, S M, Hickie, I B, Hougaard, D M, Krauter, K, Lind, P A, McClintick, J N, McQueen, M B, Meyers, J L, Montgomery, G W, Mors, O, Mortensen, P B, Nordentoft, M, Pearson, J F, Peterson, R E, Werge, T & Psychiatric Genomics Consortium Substance Use Disorders Workgroup 2020, ' A large-scale genome-wide association study meta-analysis of cannabis use disorder ', The Lancet Psychiatry, vol. 7, no. 12, pp. 1032-1045 . https://doi.org/10.1016/S2215-0366(20)30339-4
Psychiatric Genomics Consortium Substance Use Disorders Workgroup 2020, ' A large-scale genome-wide association study meta-analysis of cannabis use disorder ', The Lancet Psychiatry, vol. 7, no. 12, pp. 1032-1045 . https://doi.org/10.1016/S2215-0366(20)30339-4
The Lancet Psychiatry

Background: Variation in liability to cannabis use disorder has a strong genetic component (estimated twin and family heritability about 50–70%) and is associated with negative outcomes, including increased risk of psychopathology. The aim of the s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5e1394595d95a3f48eb1610651d6d82
https://doi.org/10.1016/s2215-0366(20)30339-4

83. FAMILY HISTORY SCORES COMPLEMENT POLYGENIC SCORE DESCRIPTIONS OF PSYCHIATRIC GENETIC ARCHITECTURE: THEORY AND PRACTICE

Autor: Morten Krebs, Kajsa-Lotta Georgii Hellberg, Vivek Appadurai, Henrik Ohlsson, Bjarni Vilhjalmsson, Silviu-Alin Bacanu, Jonathan Flint, Na Cai, Noah Zaitlen, Andres Ingason, Alfonso Buil, Andy Dahl, Kenneth Kendler, Thomas Werge, Andrew Schork

Publikováno v: European Neuropsychopharmacology. 63:e89-e90

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::519004c52a7fc66a56d95805bcecfc78
https://doi.org/10.1016/j.euroneuro.2022.07.168