Zobrazeno 1 - 10
of 514
pro vyhledávání: '"Kenneth K. W. To"'
Autor:
Chuan Yang, Xueping Wang, Kenneth K. W. To, Caimei Cui, Min Luo, Shaocong Wu, Lamei Huang, Kai Fu, Can Pan, Zeyu Liu, Teng Fan, Caibo Yang, Fang Wang, Liwu Fu
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-18 (2024)
Abstract Circulating tumor cells (CTCs) are precursors of distant metastasis in a subset of cancer patients. A better understanding of CTCs heterogeneity and how these CTCs survive during hematogenous dissemination could lay the foundation for therap
Externí odkaz:
https://doaj.org/article/ca5c2d9183ac44d7ae251b67aa37906b
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/cd5d1e39b14541d185b615e3a1d62982
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-17 (2023)
Abstract Cancer development is closely associated with immunosuppressive tumor microenvironment (TME) that attenuates antitumor immune responses and promotes tumor cell immunologic escape. The sequential conversion of extracellular ATP into adenosine
Externí odkaz:
https://doaj.org/article/6d26402fc76e4c14b1abd991152338c3
Autor:
Kenneth K. W. To, William C. Cho
Publikováno v:
Pharmaceutics, Vol 15, Iss 8, p 2166 (2023)
Immune checkpoint inhibitors (ICI) have achieved unprecedented clinical success in cancer treatment. However, drug resistance to ICI therapy is a major hurdle that prevents cancer patients from responding to the treatment or having durable disease co
Externí odkaz:
https://doaj.org/article/cff4bee326f14685931869c2dff75e74
Publikováno v:
Molecules, Vol 28, Iss 7, p 3043 (2023)
The mammalian bromodomain and extra-terminal domain (BET) family of proteins consists of four conserved members (Brd2, Brd3, Brd4, and Brdt) that regulate numerous cancer-related and immunity-associated genes. They are epigenetic readers of histone a
Externí odkaz:
https://doaj.org/article/d971e40697a3416aa0a2c4a195a845ac
Autor:
Shaocong Wu, Min Luo, Kenneth K. W. To, Jianye Zhang, Chaoyue Su, Hong Zhang, Sainan An, Fang Wang, Da Chen, Liwu Fu
Publikováno v:
Molecular Cancer, Vol 20, Iss 1, Pp 1-17 (2021)
Abstract Background Epidermal growth factor receptor (EGFR)-mutated lung cancer constitutes a major subgroup of non-small cell lung cancer (NSCLC) and osimertinib is administrated as first-line treatment. However, most patients with osimertinib treat
Externí odkaz:
https://doaj.org/article/b902aaea868f410eb59410beb86f0629
Autor:
Hong Zhang, Yuhui Xia, Fang Wang, Min Luo, Ke Yang, Shaobo Liang, Sainan An, Shaocong Wu, Chuan Yang, Da Chen, Meng Xu, Muyan Cai, Kenneth K. W. To, Liwu Fu
Publikováno v:
Advanced Science, Vol 8, Iss 10, Pp n/a-n/a (2021)
Abstract Despite the great success of immunotherapy in a small subset of cancer patients, most colorectal cancer (CRC) patients do not respond to programmed cell death receptor 1 (PD‐1) blockade immunotherapy. There is an urgent medical need to elu
Externí odkaz:
https://doaj.org/article/4ccf39e0ce7f4b05874c26f77c7d7217
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Lung cancer is the leading cause of cancer-related deaths worldwide. Immune checkpoint inhibitors, including monoclonal antibodies against programmed death-1 (PD-1) and programmed death ligand-1 (PD-L1), have dramatically improved the survival and qu
Externí odkaz:
https://doaj.org/article/e4493cbfa2c64252b17bca3dd1e4cbbf
Autor:
Xiaoran Guo, Kenneth K. W. To, Zhen Chen, Xiaokun Wang, Jianye Zhang, Min Luo, Fang Wang, Shirong Yan, Liwu Fu
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 37, Iss 1, Pp 1-13 (2018)
Abstract Background ATP-binding cassette subfamily G member 2 (ABCG2), a member of the ABC transporter superfamily proteins, mediates multidrug resistance (MDR) by transporting substrate anticancer drugs out of cancer cells and decreasing their intra
Externí odkaz:
https://doaj.org/article/f7a56167f4964b6780690c3a4b93849e
Autor:
Wei Yan, Ruide He, Xiaojiao Tang, Bin Tian, Yannan Liu, Yigang Tong, Kenneth K. W. To, Sharon S. Y. Leung
Publikováno v:
Pharmaceutics, Vol 13, Iss 8, p 1162 (2021)
The feasibility of using respirable bacteriophage (phage) powder to treat lung infections has been demonstrated in animal models and clinical studies. This work investigated the influence of formulation compositions and excipient concentrations on th
Externí odkaz:
https://doaj.org/article/a0d3185effa5455e97f6aa7115bf561b