Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Kenneth K. Karanja"'
Autor:
Mian Zhou, Wenpeng Liu, Katharina Schlacher, Li Zheng, Judith L. Campbell, Piotr Polaczek, Vencat Popuri, Kenneth K. Karanja, Hongzhi Li, Zhengke Li, Qiong Wu, Changwei Liu, Shu-ou Shan, Binghui Shen, Huifang Dai
Publikováno v:
EBioMedicine
Cancer cells frequently up-regulate DNA replication and repair proteins such as the multifunctional DNA2 nuclease/helicase, counteracting DNA damage due to replication stress and promoting survival. Therefore, we hypothesized that blocking both DNA r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1a89137fa1ded1373f3d7c292aee484
Lipid Droplet-Derived Monounsaturated Fatty Acids Traffic via PLIN5 to Allosterically Activate SIRT1
Autor:
Mallory P. Franklin, Mark J. Graham, Linnea E. Mead, Timothy D. Heden, Kenneth K. Karanja, Bruce A. Witthuhn, Laurie L. Parker, Charles P. Najt, Douglas G. Mashek, Lisa S. Chow, Minervo Perez, Mara T. Mashek, Jason L. Heier, Salmaan A. Khan, David A. Bernlohr
Publikováno v:
Mol Cell
Lipid droplets (LDs) provide a reservoir for triacylglycerol storage and are a central hub for fatty acid trafficking and signaling in cells. Lipolysis promotes mitochondrial biogenesis and oxidative metabolism via a SIRT1/PGC-1α/PPARα-dependent pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e63a41d9d608077141054c95b07a0ce
https://doi.org/10.1016/j.molcel.2019.12.003
https://doi.org/10.1016/j.molcel.2019.12.003
Autor:
John W. Phillips, Judith L. Campbell, Peter B. Dervan, Chieh Mei Wang, Benjamin C. Li, Thomas F. Martinez, Piotr Polaczek, Kenneth K. Karanja
Publikováno v:
Nucleic Acids Research
Pyrrole-imidazole polyamides targeted to the androgen response element were cytotoxic in multiple cell lines, independent of intact androgen receptor signaling. Polyamide treatment induced accumulation of S-phase cells and of PCNA replication/repair
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18740e971eeddeb03f5585313d0d2c4f
https://resolver.caltech.edu/CaltechAUTHORS:20140929-091558705
https://resolver.caltech.edu/CaltechAUTHORS:20140929-091558705
FANCD2 is required for the repair of DNA damage by the FA (Fanconi anemia) pathway, and, consequently, FANCD2-deficient cells are sensitive to compounds such as cisplatin and formaldehyde that induce DNA:DNA and DNA:protein crosslinks, respectively.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40af03086369e00782c06e4ea881d31e
https://europepmc.org/articles/PMC4050159/
https://europepmc.org/articles/PMC4050159/
Publikováno v:
Cell Cycle
During DNA replication, stalled replication forks and DSBs arise when the replication fork encounters ICLs (interstrand crosslinks), covalent protein/DNA intermediates or other discontinuities in the template. Recently, homologous recombination prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c32d1254b9253f64807b4cd882d72fc6
https://resolver.caltech.edu/CaltechAUTHORS:20121130-084457932
https://resolver.caltech.edu/CaltechAUTHORS:20121130-084457932
Autor:
Yuchi Honaker, Raymond J. Monnat, Julien P. Duxin, Judith L. Campbell, Helen Piwnica-Worms, Sheila A. Stewart, Hayley R. Moore, Kenneth K. Karanja, Julia M. Sidorova, Benjamin Dao
Publikováno v:
The Journal of biological chemistry. 287(26)
Dna2 is an essential helicase/nuclease that is postulated to cleave long DNA flaps that escape FEN1 activity during Okazaki fragment (OF) maturation in yeast. We previously demonstrated that the human Dna2 orthologue (hDna2) localizes to the nucleus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d074e5cb0004a7a6a1929d1ac96134c9
https://pubmed.ncbi.nlm.nih.gov/22570476
https://pubmed.ncbi.nlm.nih.gov/22570476
Publikováno v:
The FASEB Journal. 26
Double stranded breaks (DSB) are lesions repaired by the homologous recombination (HR) pathway during S/G2 phase. MRN/CtIP nuclease activity initiates a short 5' end resection followed by a longer resection to generate a recombinogenic 3' ssDNA suffi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db45e80da1a0dc53f7b76d48b301f8a9
https://doi.org/10.1096/fasebj.26.1_supplement.539.1
https://doi.org/10.1096/fasebj.26.1_supplement.539.1
Autor:
Duxin JP; Department of Cell Biology and Physiology, University of Washington, Seattle, Washington 98195, USA., Moore HR, Sidorova J, Karanja K, Honaker Y, Dao B, Piwnica-Worms H, Campbell JL, Monnat RJ Jr, Stewart SA
Publikováno v:
The Journal of biological chemistry [J Biol Chem] 2012 Jun 22; Vol. 287 (26), pp. 21980-91. Date of Electronic Publication: 2012 May 07.