Zobrazeno 1 - 10
of 425
pro vyhledávání: '"Kenneth K Wu"'
Autor:
Kenneth K Wu
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Tissue fibrosis causes debilitating human diseases such as liver cirrhosis, heart failure, chronic kidney disease and pulmonary insufficiency. It is a dynamic process orchestrated by specific subsets of monocyte-macrophages, fibroblasts, pericytes an
Externí odkaz:
https://doaj.org/article/bed014173b834a0b8b8103a795a28c8a
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0152166 (2016)
The endothelial junction is tightly controlled to restrict the passage of blood cells and solutes. Disruption of endothelial barrier function by bacterial endotoxins, cytokines or growth factors results in inflammation and vascular damage leading to
Externí odkaz:
https://doaj.org/article/449283d47d514b00a23a420270b779da
Autor:
Jaewoo Song, Fengju Chen, Marco Campos, Doug Bolgiano, Katie Houck, Lloyd E Chambless, Kenneth K Wu, Aaron R Folsom, David Couper, Eric Boerwinkle, Jing-fei Dong
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0132626 (2015)
ABO blood groups are known to influence the plasma level of von Willebrand factor (VWF), but little is known about the relationship between ABO and coagulation factor VIII (FVIII). We analyzed the influence of ABO genotypes on VWF antigen, FVIII acti
Externí odkaz:
https://doaj.org/article/4e1fdc9c61e344289e2ca520cef92892
High glucose induces bone marrow-derived mesenchymal stem cell senescence by upregulating autophagy.
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0126537 (2015)
Hyperglycemia was reported to cause bone marrow hematopoietic niche dysfunction, and high glucose (HG) in the cultured medium induces MSC senescence. The underlying mechanism is unclear. Here, we investigated the role of HG-induced autophagy in bone-
Externí odkaz:
https://doaj.org/article/ac6c6afb6f5040218fc1bdee4b4b9281
Autor:
Huei-Hsuan Cheng, Kai-Hsuan Wang, Ling-yun Chu, Tzu-Ching Chang, Cheng-Chin Kuo, Kenneth K Wu
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88507 (2014)
Quiescent fibroblasts possess unique genetic program and exhibit high metabolic activity distinct from proliferative fibroblasts. In response to inflammatory stimulation, quiescent fibroblasts are more active in expressing cyclooxygenase-2 and other
Externí odkaz:
https://doaj.org/article/22876c62dd85435a924c927fa6e7799b
Autor:
Zhou Zhou, Fuli Yu, Ashley Buchanan, Yuanyuan Fu, Marco Campos, Kenneth K Wu, Lloyd E Chambless, Aaron R Folsom, Eric Boerwinkle, Jing-fei Dong
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e84810 (2014)
The synthesis, secretion and clearance of von Willebrand factor (VWF) are regulated by genetic variations in coding and promoter regions of the VWF gene. We have previously identified 19 single nucleotide polymorphisms (SNPs), primarily in introns th
Externí odkaz:
https://doaj.org/article/8990785f894e452f9125e6db1d229d43
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69702 (2013)
We hypothesized that prostacyclin (PGI2) protects vascular smooth muscle cell (VSMC) against apoptosis and phenotypic switch through peroxisome proliferator-activated receptor-α (PPARα) activation and 14-3-3 upregulation. Here we showed that transf
Externí odkaz:
https://doaj.org/article/ce43496addb74a138c9aabf73b5fd7cd
14-3-3σ regulates β-catenin-mediated mouse embryonic stem cell proliferation by sequestering GSK-3β.
Autor:
Tzu-Ching Chang, Chia-Chia Liu, En-Wei Hsing, Shu-Man Liang, Ya-Hui Chi, Li-Ying Sung, Shau-Ping Lin, Tang-Long Shen, Bor-Sheng Ko, B Linju Yen, Shaw-Fang Yet, Kenneth K Wu, Jun-Yang Liou
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e40193 (2012)
Pluripotent embryonic stem cells are considered to be an unlimited cell source for tissue regeneration and cell-based therapy. Investigating the molecular mechanism underlying the regulation of embryonic stem cell expansion is thus important. 14-3-3
Externí odkaz:
https://doaj.org/article/255a8a5539524344a1de1ab1886c5bf4
Autor:
Bo-Rui Chen, Huei-Hsuan Cheng, Wei-Chung Lin, Kai-Hsuan Wang, Jun-Yang Liou, Pei-Feng Chen, Kenneth K Wu
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49232 (2012)
Quiescent cells are considered to be dormant. However, recent studies suggest that quiescent fibroblasts possess active metabolic profile and certain functional characteristics. We previously observed that serum-starved quiescent fibroblasts respond
Externí odkaz:
https://doaj.org/article/b924b5716db4415a9216dae1fd801117
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39851 (2012)
BACKGROUND: Human endothelial nitric oxide synthase (eNOS) requires calcium-bound calmodulin (CaM) for electron transfer but the detailed mechanism remains unclear. METHODOLOGY/PRINCIPAL FINDINGS: Using a series of CaM mutants with E to Q substitutio
Externí odkaz:
https://doaj.org/article/c326b9405ba34811bce4428b7ab07013