Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Kenneth James Junior Henry"'
Autor:
Mark Edward Rempala, Tom Raub, Carlos Mateos, Sehila Pleite, Josh Clayton, William J. Ehlhardt, Huaxing Pei, Bradley Condon, Stephanie L. Stout, Sheela Ashok, Sandaruwan Geeganage, Mei Lai, Burkholder Timothy P, Deidre Michelle Johns, Yong Wang, Kenneth James Junior Henry, Saravanan Parthasarathy, Zhohai Lu, Oscar de Frutos, Pablo A. García
Publikováno v:
Bioorganicmedicinal chemistry letters. 28(10)
During the course of our research efforts to develop potent and selective AKT inhibitors, we discovered enatiomerically pure substituted dihydropyridopyrimidinones (DHP) as potent inhibitors of protein kinase B/AKT with excellent selectivity against
Autor:
Xu Jiansheng, Radhe K. Vaid, Baitao Gao, Sathish K. Boini, Jeremy T. Spitler, Xiaoquan Lu, Kenneth James Junior Henry
Publikováno v:
Synthesis. 44:2231-2236
A practical synthesis of the title compound was accomplished by hydrogenation of 2-{4-[4-fluoro-3-(trifluoromethyl)phenyl]-2-(pyridin-4-yl)-1 H -imidazol-1-yl}- N , N -dimethylethanamine. The latter was obtained by N-alkylation of 4-{4-[4-fluoro-3-(t
Publikováno v:
Tetrahedron Letters. 48:1791-1794
Reaction of a variety of tert-butyl carbamates under glycosylation conditions gives rise to anomeric 2-deoxy-2-amino sugar carbamates in a good to excellent yields. The reaction exhibits good tolerance to several common protecting groups, and has bee
Autor:
Anna Riley, Qin Sheng, Dalai Yan, Kenneth James Junior Henry, J. Estelle Foster, Pei-Ming Sun, Malcolm E. Winkler, Wai-Leung Ng, Raymond Gilmour, Thalia I. Nicas, Jonathan R. McClain
Publikováno v:
Journal of Bacteriology. 187:8196-8200
Bacterial histidine kinases have been proposed as targets for the discovery of new antibiotics, yet few specific inhibitors of bacterial histidine kinases have been reported. We report here a novel thienopyridine (TEP) compound that inhibits bacteria
Autor:
Kenneth James Junior Henry, J. Estelle Foster, Mark G. Bures, Thalia I. Nicas, Malcolm E. Winkler, Raymond Gilmour, Qin Sheng, Jonathan R. McClain
Publikováno v:
Microbiology. 150:885-896
Two-component signal transduction systems (TCSs) play fundamental roles in bacterial survival and pathogenesis and have been proposed as targets for the development of novel classes of antibiotics. A new coupled assay was developed and applied to ana
Autor:
Richard J. Miller, Kenneth James Junior Henry, Jayana Pankaj Lineswala, Baolin Li, Dongjun Ren, David M. Chan, Matthew S. Ripsch, Fletcher A. White, Sonia K. Bhangoo, Chafiq Hamdouchi, Patrick E Monahan
Publikováno v:
Molecular Pain, Vol 3, Iss 1, p 38 (2007)
Molecular Pain
Molecular Pain
Background: Animal and clinical studies have revealed that focal peripheral nerve axon demyelination is accompanied by nociceptive pain behavior. C-C and C-X-C chemokines and their receptors have been strongly implicated in demyelinating polyneuropat
Autor:
Sajeev Cherian, Shi-Chung Ng, Joy Bauch, Haichao Zhang, Jerry Cohen, Greg Donner, Badr Saeed, Stephen K. Tahir, Wang Shen, Robert B. Warner, Hing L. Sham, Kenneth James Junior Henry, Kennan C. Marsh, Saul H. Rosenberg, Peter Kovar, Stephen A. Fakhoury, Jang Lee
Publikováno v:
Bioorganicmedicinal chemistry letters. 9(5)
Synthesis and biological evaluation of heteroarenes as reduced cysteine replacements are described. Of the heteroaryl groups examined with respect to FT inhibitor FTI-276 (1), pyridyl was the replacement found to be most effective. Substitutions at C