Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Kenneth J. Stauffer"'
Autor:
Sidney D Lewis, Assunta S Ng, Elizabeth A Lyle, Michael J Mellott, Sandra D Appleby, Stephen F Brady, Kenneth J Stauffer, John T Sisko, Shi-Shan Mao, Daniel F Veber, Ruth F Nutt, Joseph J Lynch, Jacquelynn J Cook, Stephen J Gardll, Jules A Shafer
Publikováno v:
Thrombosis and Haemostasis. 74:1107-1112
SummarySeveral H-N-Me-D-Phe-Pro-Lysyl-α-keto carbonyl derivatives were shown to be potent thrombin inhibitors (Ki 0.2 to 27 nM). The inhibitory potencies of these compounds toward tissue plasminogen activator, plasmin and factor Xa were minimal; how
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82a9f063f2c4aff255d3682a9e5f18f3
https://doi.org/10.1055/s-0038-1649889
https://doi.org/10.1055/s-0038-1649889
Autor:
James C. Barrow, Kenneth E. Rittle, Lawrence C. Kuo, Audrey A. Wallace, Bobby J. Lucas, George F. Lundell, Beth Pietrak, Harold G. Selnick, Rebecca B. White, S. Dale Lewis, Franklin C. Clayton, Christina L. Newton, Youwei Yan, Janetta M. Pellicore, Daniel R. McMasters, Peter D. Williams, Philippe G. Nantermet, Kenneth J. Stauffer, Bradley K. Wong, Cynthia Miller-Stein, Kristen L. Glass, Julie A. Krueger, Mary Beth Young, Jacquelynn J. Cook, Joseph P. Vacca, Dennis L. Bohn
Publikováno v:
Journal of medicinal chemistry. 47(12)
In an effort to discover potent, clinically useful thrombin inhibitors, a rapid analogue synthetic approach was used to explore the P(1) region. Various benzylamines were coupled to a pyridine/pyrazinone P(2)-P(3) template. One compound with an o-thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ebdb36312ce61d537b8ef9c3036ccbb
https://pubmed.ncbi.nlm.nih.gov/15163182
https://pubmed.ncbi.nlm.nih.gov/15163182