Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Kenneth J. Ruterbories"'
Publikováno v:
Bioanalysis. 15:295-300
In contrast to quantification of biotherapeutics, endogenous protein biomarker and target quantification using LC–MS based targeted proteomics can require a much more stringent and time-consuming tryptic signature peptide selection for each specifi
Publikováno v:
Bioanalysis. 14(5)
Background: Currently, no regulatory guidelines are available for parallelism assessment for LC-MS biomarker quantification. Spike recovery, standard addition and dilutional linearity are recommended with no mention of the implications of applying th
Publikováno v:
Journal of Chromatography B. :356-363
With increasing knowledge on the role of hepatic transporters in drug disposition, numerous efforts have been described to quantify the expression of human hepatic transporters. However, reported quantitative proteomic approaches often require long a
Autor:
David T. White, Naijia Huang, Jeffrey S. Tan, Kenneth J. Ruterbories, Jason Liu, Derek Brocksmith, Lee J. Burns, Alain Stricker-Krongrad, Nathan Yumibe, Nita J. Patel, Guy Bouchard
Publikováno v:
International Journal of Pharmacokinetics. 2:81-91
Aim: Oral and intravenous pharmacokinetic (PK) studies were conducted in four different minipig strains: Sinclair, Yucatan, Hanford and Göttingen after administration of metformin or R,S-verapamil (R,S-VER). Results: The results indicated that the P
Publikováno v:
Drug Metabolism and Disposition. 44:1819-1827
Surrogate assays for drug metabolism and inhibition are traditionally performed in buffer systems at pH 7.4, despite evidence that hepatocyte intracellular pH is 7.0. This pH gradient can result in a pKa-dependent change in intracellular/extracellula
Autor:
David W. Bedwell, Luc Rougée, Jeff W Cramer, Nathan A Calvert, Nathan Yumibe, Kenneth J. Ruterbories, Kenneth C. Cassidy, Richard Moulton, Michael A. Mohutsky, Lisa A. Adams, Xin Zhou
Publikováno v:
Drug Metabolism and Disposition. 44:1184-1192
The Zucker diabetic fatty (ZDF) rat, an inbred strain of obese Zucker fatty rat, develops early onset of insulin resistance and displays hyperglycemia and hyperlipidemia. The phenotypic changes resemble human type 2 diabetes associated with obesity a
Autor:
Boris A. Czeskis, Demetrio Ortega, Brian W. Pack, Aktham Aburub, Chris Ward, David S. Small, Ellen A. Cannady, Syeda L. Begum, William F. Annes, Jane Royalty, Qun Lin, Kenneth J. Ruterbories, Chris Hinds, Jeffrey G. Suico
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 59:238-244
This open-label, single-period study in healthy subjects estimated evacetrapib absolute bioavailability following simultaneous administration of a 130-mg evacetrapib oral dose and 4-h intravenous (IV) infusion of 175 µg [(13) C8 ]-evacetrapib as a t
Publikováno v:
Pharmaceutical Research. 35
One of the authors has his name incorrectly indexed in PubMed and SpringerLink as “Laird Forrest M” (last name “Laird Forrest”). His name should index as “Forrest M. Laird” with last name as “Forrest”.
Publikováno v:
Pharmaceutical Research. 35
PURPOSE: To investigate influence of inflammation on metabolism and pharmacokinetics (PK) of midazolam (MDZ) and construct a semi-physiologically based pharmacokinetic (PBPK) model to predict PK in mice with inflammatory disease. METHODS: Glucose-6-p
Publikováno v:
Drug Metabolism and Disposition. 43:756-761
To characterize the hydrolysis of the peptide prodrug pomaglumetad methionil (LY2140023; (1R,4S,5S,6S)-4-(L-methionylamino)-2-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid 2,2-dioxide), to the active drug LY404039 [(1R,4S,5S,6S)-4-amino-2-thiabicycl