Data from MM-141, an IGF-IR– and ErbB3-Directed Bispecific Antibody, Overcomes Network Adaptations That Limit Activity of IGF-IR Inhibitors

Autor: Alexey A. Lugovskoy, Ulrik B. Nielsen, Birgit Schoeberl, Kenneth J. Olivier, Brian D. Harms, Yang Jiao, Maja Razlog, Rachel Rennard, Neeraj Kohli, Lihui Xu, Victoria Rimkunas, Jian Tang, Sergio Iadevaia, Sharlene Adams, Jason Baum, Bryan W. Johnson, Jonathan B. Fitzgerald

Although inhibition of the insulin-like growth factor (IGF) signaling pathway was expected to eliminate a key resistance mechanism for EGF receptor (EGFR)-driven cancers, the effectiveness of IGF-I receptor (IGF-IR) inhibitors in clinical trials has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::63aadf5ac0a5228ff209cf3c30de8a8a
https://doi.org/10.1158/1535-7163.c.6536614.v1

Supplementary Figure Legends from MM-141, an IGF-IR– and ErbB3-Directed Bispecific Antibody, Overcomes Network Adaptations That Limit Activity of IGF-IR Inhibitors

Autor: Alexey A. Lugovskoy, Ulrik B. Nielsen, Birgit Schoeberl, Kenneth J. Olivier, Brian D. Harms, Yang Jiao, Maja Razlog, Rachel Rennard, Neeraj Kohli, Lihui Xu, Victoria Rimkunas, Jian Tang, Sergio Iadevaia, Sharlene Adams, Jason Baum, Bryan W. Johnson, Jonathan B. Fitzgerald

PDF - 91K, Supplementary Figure Legends.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad1d1c7471f02ecb8c6eef01f33fceae
https://doi.org/10.1158/1535-7163.22500904.v1

Unbiased Screens Show CD8+ T Cells of COVID-19 Patients Recognize Shared Epitopes in SARS-CoV-2 that Largely Reside outside the Spike Protein

Autor: Alexander W. Cristofaro, Candace R. Perullo, Gavin MacBeath, Tomasz Kula, Amy Virbasius, Qikai Xu, Shrikanta Chattopadhyay, Lyndsey R. Buckner, Kenneth J. Olivier, Garrett S. Dunlap, Andrew P. Ferretti, Holly J. Whitton, Dalena M.V. Nguyen, Adam Weinheimer, Yifan Wang, Eric D. Whitman, Nancy Nabilsi, Sarah A. Bertino, Angela Tatiana Alistar

Publikováno v: Immunity

Developing effective strategies to prevent or treat coronavirus disease 2019 (COVID-19) requires understanding the natural immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We used an unbiased, genome-wide screening tec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d95fa9b857d72cfa5e440693b360cd80

COVID-19 Patients Form Memory CD8+ T Cells that Recognize a Small Set of Shared Immunodominant Epitopes in SARS-CoV-2

Autor: Sarah A. Bertino, Gavin MacBeath, Nancy Nabilsi, Alexander W. Cristofaro, Candace R. Perullo, Shrikanta Chattopadhyay, Eric D. Whitman, Angela Tatiana Alistar, Kenneth J. Olivier, Garrett S. Dunlap, Lyndsey R. Buckner, Amy Virbasius, Adam Weinheimer, Qikai Xu, Yifan Wang, Andrew P. Ferretti, Tomasz Kula, Holly J. Whitton, Dalena M.V. Nguyen

Development of effective strategies to detect, treat, or prevent COVID-19 requires a robust understanding of the natural immune response to SARS-CoV-2, including the cellular response mediated by T cells. We used an unbiased, genome-wide screening te

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4de2050b99a033eb27aff6f157709ca4

List of Contributors

Autor: Martins O. Ainerua, Iris An, Charles C. Barton, Sol Bobst, Marie Bourgeois, Megan Branson, Bruce Busby, Brenda Carito, Clark Carrington, Grace A. Chappell, Guang-Di Chen, Debra Cherry, Karen Chou, Joseph A. Cichocki, Louis Anthony Cox, Yuri Bruinen de Bruin, Aisha S. Dickerson, David C. Dorman, Ruth A. Etzel, Allan S. Felsot, Jeremy A. Freeman, Katie Frevert, Elizabeth Friedman, Shayne Gad, Victoria Gifford, Steven G. Gilbert, Julie E. Goodman, Anshul Gupta, Kevin Guth, Axel Hahn, Raymond D. Harbison, Esther M. Haugabrooks, A. Wallace Hayes, Antoinette Hayes, Stacey Herriage, Richard C. Hertzberg, Stephanie Holmgren, Tamara House-Knight, Sara T. Humes, Devin Hunt, William Irwin, Maryam Zare Jeddi, Samantha J. Jones, James E. Klaunig, Cecile M. Krejsa, Meredith G. Lassiter, Abby A. Li, Edward P. Locke, Heather N. Lynch, Andrew Maier, Stacey Mantooth, M. Elizabeth Marder, Asish Mohapatra, Virginia Moser, M. Moiz Mumtaz, Lewis S. Nelson, Kenneth J. Olivier, Amanda S. Persad, Mark Pershouse, Rebekah Petroff, Carey Pope, Elizabeth Putnam, Gary O. Rankin, Glenn E. Rice, Tara Sabo-Attwood, Cynthia Santos, Barbara B. Saunders-Price, Johanna E. Schaaper, Dietrich (Dieter) Schwela, Jane Ellen Simmons, Gregory J. Smith, Kenneth R. Still, Frederick W. Stoss, Dexter W. Sullivan, Michele R. Sullivan, Alicia A. Taylor, Greet B.A. Teuns, Karen Tilmant, Monica A. Valentovic, Sander Van Der Linden, Nina Ching Y. Wang, Katherine D. Watson, Eleanor Weston, Philip Wexler, Catherine F. Wise, James T.F. Wise, John Pierce Wise, John P. Wise, Jamie L. Young, Robert R. Young

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dd2be67a05c56e5361ae693894a43e19
https://doi.org/10.1016/b978-0-12-813724-6.00087-6