Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Kenneth J. Natalie"'
Autor:
Hua Gong, Thomas M. Razler, Zhongmin Xu, Victor W. Rosso, Cuniere Nicolas, Steven Tymonko, Nuria de Mas, Kenneth J. Natalie, Eric W. Sortore, Monica L. Adams, David A. Conlon, David S. Weinstein, Fernando Quiroz, Kenneth J. Fraunhoffer, Jason Zhu, Anisha Patel, Jun Huang, Doris C. Chen
Publikováno v:
Organic Process Research & Development. 20:921-933
An efficient route to two functionalized 2-aryl-5H-chromeno[2,3-b]pyridines (azaxanthenes) is reported. The addition of lithiated 2,6-dichloropyridine to salicylaldehyde followed by cyclization was a key process improvement identified for the formati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e8dc210e7539d59eac177deae3d5dca
https://doi.org/10.1021/acs.oprd.6b00035
https://doi.org/10.1021/acs.oprd.6b00035
Autor:
David A. Conlon, Nuria de Mas, Kenneth J. Natalie, Fernando Quiroz, Doris C. Chen, Victor W. Rosso
Publikováno v:
Organic Process Research & Development. 20:934-939
Preparative chiral supercritical fluid chromatography (SFC) employing an enantioenriched feedstock obtained via partial classical resolution enabled rapid access to kilogram quantities of a key intermediate common to two glucocorticoid (GC) receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f46a64333ac20924e2262d45c1646129
https://doi.org/10.1021/acs.oprd.6b00036
https://doi.org/10.1021/acs.oprd.6b00036
Autor:
Rossano Lucius T, Michael A. Schmidt, Vu Chi Truc, Jacob Albrecht, Andrew G. Lee, Xinhua Qian, Ehrlic Lo, Steven L. Goldberg, Emily A. Reiff, Jaan A. Pesti, Chao Hang, Kenneth J. Natalie, Animesh Goswami, Zhiwei Guo, Chenchi Wang
Publikováno v:
Organic Process Research & Development. 19:1317-1322
The process development and large scale synthesis for the β-hydroxyamino amide 1 is described. The route evolved from a multistep sequence utilizing a classical resolution to a two-step enantioselective process involving an enzyme-catalyzed aldol re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e78e620e78b1f8852562c1c09f2eda3c
https://doi.org/10.1021/acs.oprd.5b00192
https://doi.org/10.1021/acs.oprd.5b00192
Autor:
Zhiwei Guo, Animesh Goswami, Steven L. Goldberg, Kenneth J. Natalie, Vu Chi Truc, Chao Hang, Rossano Lucius T, Michael A. Schmidt, Andrew G. Lee, Ehrlic Lo, Yeung Y. Chan
Publikováno v:
Organic Process Research & Development. 19:1308-1316
The chiral β-hydroxy-α-amino acid, (2R,3S)-2-amino-3-hydroxy-3-(pyridin-4-yl)-propanoic acid, is a key intermediate in the synthesis of the API (2R,3S)-2-amino-3-hydroxy-3-(pyridin-4-yl)-1-(pyrrolidin-1-yl)propan-1-one, a developmental drug candida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb02e24fc17ba2492c2cb3e297aff494
https://doi.org/10.1021/acs.oprd.5b00191
https://doi.org/10.1021/acs.oprd.5b00191
Publikováno v:
Organic Process Research & Development. 17:257-264
The evolution of a process for the preparation of a new heterocyclic dual NK1/serotonin receptor antagonist is described. The final synthesis features a telescoped sequence in which an iron(III)-catalyzed Grignard coupling is followed by a benzylic c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc6dc642699cce2f03ecbcc654a4342c
https://doi.org/10.1021/op300323k
https://doi.org/10.1021/op300323k
Autor:
John D. Dimarco, Shankar Swaminathan, Brian Burke, Thomas P. Kissick, Oak K. Kim, Bin Zheng, Janak Singh, Kenneth J. Natalie, Goodrich Jason, Juliya Livshits, Matthew A. Brown, John A. Grosso, Zhinong Gao, Michael J. Humora, Anthony P. Dutka, Peter Hans Ermann, David R. Kronenthal, Gerard A. Crispino, Richard H. Mueller, John A. Wichtowski, Jeffrey T. North, Joanne J. Bronson, Jack Z. Gougoutas, Yasutsugu Ueda, Dane M. Springer, Peter Schierling, Bing Yu Luh, James E. Heikes, Dau-Ming Hsieh, Anne J. Pullockaran, Bo Zhang, Robert K. Perrone, Mei C. Lai, and Theodor W. Denzel, Yunhui Zhang
Publikováno v:
Organic Process Research & Development. 4:488-497
A practical synthesis of the anti-methicillin resistant Staphylococcus aureus cephem (6R-trans)-E-7-[[[[2,5-dichloro-4-[3-[(carboxymethyl)amino]-3-oxo-1-propenyl]phenyl]-thio]-acetyl]amino]-4-[[(2-carboxy-8-oxo-5-thia-1-azabicyclo-[4.2.0]oct-2-en-3-y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::030fc232263c59de1340816a124920ab
https://doi.org/10.1021/op0002850
https://doi.org/10.1021/op0002850
Autor:
Bang-Chi Chen, Andrew Rusowicz, Ronald F Eiring, Francis J. Okuniewicz, Valerie Zannella, Kenneth J. Natalie, Shawn K. Pack, Ramesh N. Patel, Steven R. Schwarz, Kai S Tse, John J. Venit, Susan C Durand, John M. Wasylyk, Bruce T Lotz, Keith Ramig, Ronald L. Hanson, John C. Harris, William L. Parker, Shankar Swaminathan, Victor W. Rosso, David A. Lust, Mary Jo Donovan, Laszlo J. Szarka, Mark Liu, Laporte Thomas L, Michael A. Montana, Dana L Cazzulino, Venkata B. Nanduri, Peter J. Bernot, Jeffrey M. Howell
Publikováno v:
Enzyme and Microbial Technology. 26:348-358
Allysine ethylene acetal [(S)-2-amino-5-(1,3-dioxolan-2-yl)-pentanoic acid (2)] was prepared from the corresponding keto acid by reductive amination using phenylalanine dehydrogenase (PDH) from Thermoactinomyces intermedius ATCC 33205. Glutamate, ala
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e3a09021bd4305ecd5ef317f78de9a3
https://doi.org/10.1016/s0141-0229(99)00175-1
https://doi.org/10.1016/s0141-0229(99)00175-1
Autor:
Wen Sen Li, Kenneth J. Natalie, Lee J. Silverberg, John J. Venit, Shankar Swaminathan, Ambarish K. Singh, Raymond E. Weaver, James H. Simpson
Publikováno v:
Tetrahedron Letters. 39:4769-4772
The cyclization of acetal amide was carried out with trimethylsilyl trifluoromethanesulfonate, followed by elimination using sodium methoxide to give 2,5-disubstituted oxazole, thus completing a new route to the cardivascular drug ifetroban sodium.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85ae8d01f76427c6296bcb72a90dbfe6
https://doi.org/10.1016/s0040-4039(98)00904-6
https://doi.org/10.1016/s0040-4039(98)00904-6
Autor:
Jyothi S. Pisipati, Jim-Wah Wong, Godson C. Nwokogu, Thomas D. Greenwood, Kenneth J. Natalie, Patrick T. Flaherty, James F. Wolfe
Publikováno v:
The Journal of Organic Chemistry. 62:6152-6159
Carbanions generated from 2,4,4-trimethyl-2-oxazoline (1a), 2-benzyl-4,4-dimethyl-2-oxazoline (1b), 2,4-dimethylthiazole (13a), 2-benzyl-4-methylthiazole (13b), N,N-dimethylacetamide (17a), tert-butyl acetate (17b), ethyl phenylacetate (17c), N-methy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df0dbf5097b61fa8b7888ee8d1fd2f20
https://doi.org/10.1021/jo962353f
https://doi.org/10.1021/jo962353f
Autor:
Steven L. Goldberg, Animesh Goswami, Zhiwei Guo, Yeung Chan, Ehrlic T. Lo, Andrew Lee, Vu Chi Truc, Kenneth J. Natalie, Chao Hang, Lucius T. Rossano, Michael A. Schmidt
Publikováno v:
Organic Process Research & Development; Sep2015, Vol. 19 Issue 9, p1308-1316, 9p