Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Kenneth J. Marians"'
Publikováno v:
Nucleic Acids Research. 50:2621-2634
The bacterial condensin MukB and the cellular chromosomal decatenase, topoisomerase IV interact and this interaction is required for proper condensation and topological ordering of the chromosome. Here, we show that Topo IV stimulates MukB DNA conden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51d76f80e0175b5760241365fe0db2c4
https://doi.org/10.1093/nar/gkab1027
https://doi.org/10.1093/nar/gkab1027
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 119, iss 39
In bacterial cells, DNA damage tolerance is manifested by the action of translesion DNA polymerases that can synthesize DNA across template lesions that typically block the replicative DNA polymerase III. It has been suggested that one of these TLS D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3139ce8abbc1f13229e00697773ac33
https://doi.org/10.1101/2022.04.23.489275
https://doi.org/10.1101/2022.04.23.489275
MukBEF, an SMC-like protein complex, is the bacterial condensin. It is likely that it compacts DNA via an ATP hydrolysis-dependent, DNA loop-extrusion reaction as has been demonstrated for the yeast SMC proteins condensin and cohesin. MukB also inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e45f30b8780265392fd4a7b765c9542
https://doi.org/10.1101/2022.03.08.483475
https://doi.org/10.1101/2022.03.08.483475
Autor:
Jan-Gert Brüning, Kenneth J. Marians
Publikováno v:
Nucleic Acids Research
The vast majority of the genome is transcribed by RNA polymerases. G+C-rich regions of the chromosomes and negative superhelicity can promote the invasion of the DNA by RNA to form R-loops, which have been shown to block DNA replication and promote g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06773067a4c7e6b9637c92e6f4bc0fad
http://europepmc.org/articles/PMC7544221
http://europepmc.org/articles/PMC7544221
Autor:
Kamila K. Myka, Kenneth J. Marians
Publikováno v:
J Biol Chem
Induction of the SOS response, a cellular system triggered by DNA damage in bacteria, depends on DNA replication for the generation of the SOS signal, ssDNA. RecA binds to ssDNA, forming filaments that stimulate proteolytic cleavage of the LexA trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54e47cd134f66479729daaffb4caf0be
https://doi.org/10.1074/jbc.ra120.014224
https://doi.org/10.1074/jbc.ra120.014224
Autor:
Jan-Gert Brüning, Kenneth J. Marians
Publikováno v:
Nucleic Acids Research
Collisions between the replisome and RNA polymerases [RNAP(s)] are the main obstacle to DNA replication. These collisions can occur either head-on or co-directionally with respect to the direction of translocation of both complexes. Whereas head-on c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4d88a1b46109b86412ed89b2a19046f
https://pubmed.ncbi.nlm.nih.gov/34469567
https://pubmed.ncbi.nlm.nih.gov/34469567
Publikováno v:
Journal of Biological Chemistry. 298:101964
MukBEF, a structural maintenance of chromosome-like protein complex consisting of an ATPase, MukB, and two interacting subunits, MukE and MukF, functions as the bacterial condensin. It is likely that MukBEF compacts DNA via an ATP hydrolysis-dependen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87c71b468dcab28fbdd84c6c730d495a
https://doi.org/10.1016/j.jbc.2022.101964
https://doi.org/10.1016/j.jbc.2022.101964
Autor:
Kenneth J. Marians
Publikováno v:
Annual Review of Biochemistry. 87:217-238
Accurate transmission of the genetic information requires complete duplication of the chromosomal DNA each cell division cycle. However, the idea that replication forks would form at origins of DNA replication and proceed without impairment to copy t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a60846ce883af66370fd8fb5a0ac3798
https://doi.org/10.1146/annurev-biochem-062917-011921
https://doi.org/10.1146/annurev-biochem-062917-011921
Publikováno v:
Journal of Biological Chemistry. 292:16921-16932
The bacterial condensin MukB and the cellular decatenating enzyme topoisomerase IV interact. This interaction stimulates intramolecular reactions catalyzed by topoisomerase IV, supercoiled DNA relaxation, and DNA knotting but not intermolecular react
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db6b592874f542aaa2e0730a183d2d12
https://doi.org/10.1074/jbc.m117.803346
https://doi.org/10.1074/jbc.m117.803346
Publikováno v:
Journal of Biological Chemistry. 292:13833-13842
Genome integrity relies on the ability of the replisome to navigate ubiquitous DNA damage during DNA replication. The Escherichia coli replisome transiently stalls at leading-strand template lesions and can either reinitiate replication downstream of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bad4fd852d19c75b44b222c5a5af7658
https://doi.org/10.1074/jbc.m117.800441
https://doi.org/10.1074/jbc.m117.800441