Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Kenneth J. Jakeman"'
Autor:
Pooran Chand, Clive Sweet, Linda A. Mckown, Yarlagadda S. Babu, Pamela C. Wagaman, Karen Bush, Kenneth J. Jakeman, Daksha Desai-Krieger, Anthony J. Streeter
Publikováno v:
Antimicrobial Agents and Chemotherapy. 46:996-1004
Several cyclopentane inhibitors of influenza virus neuraminidase that have inhibitory activities in tissue culture similar to those of zanamivir and oseltamivir have recently been described. These new inhibitors have been examined for efficacy agains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84a545c0b7a8a102d4ed296fffaebedc
https://doi.org/10.1128/aac.46.4.996-1004.2002
https://doi.org/10.1128/aac.46.4.996-1004.2002
Publikováno v:
FEMS Microbiology Letters. 179:175-180
Type II restriction endonuclease activities of Helicobacter pylori strain Roberts and of the type strain H. pylori NCTC 11637 were detected and analysed by conventional techniques. The endonucleases were partially purified, their optima for activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43689af2a6d9aeb99ef5578d7fecc697
https://doi.org/10.1111/j.1574-6968.1999.tb08724.x
https://doi.org/10.1111/j.1574-6968.1999.tb08724.x
Autor:
Bo Mattiasson, Kenneth J. Jakeman, Ibolya Bontidean, Gillis Johansson, Christine Berggren, Elisabeth Csöregi, Jonathan R. Lloyd, Nigel L. Brown
Publikováno v:
Scopus-Elsevier
Sensors based on proteins (GST-SmtA and MerR) with distinct binding sites for heavy metal ions were developed and characterized. A capacitive signal transducer was used to measure the conformational change following binding. The proteins were overexp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9633f9e1ccac655ba5c66164725a0c5d
https://doi.org/10.1021/ac9803636
https://doi.org/10.1021/ac9803636
Autor:
Lijun Zhang, Robert W. Sidwell, Choung U. Kim, Dirk B. Mendel, Steven A. Lacy, Weixing Li, Kenneth J. Jakeman, John H. Huffman, Matthew A. Williams, Chun Y. Tai, Ming S. Chen, James R. Merson, Norbert Bischofberger, Paul A. Escarpe, Clive Sweet, Willard Lew
Publikováno v:
Antimicrobial Agents and Chemotherapy. 42:640-646
We have recently described GS 4071, a carbocyclic transition-state analog inhibitor of the influenza virus neuraminidase, which has potent inhibitory activity comparable to that of 4-guanidino-Neu5Ac2en (GG167; zanamivir) when tested against influenz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9604cc06fc192a2f7139d772c7f26f10
https://doi.org/10.1128/aac.42.3.640
https://doi.org/10.1128/aac.42.3.640
Autor:
Ming S. Chen, Weixing Li, Dirk B. Mendel, James R. Merson, Eugene J. Eisenberg, Choung U. Kim, Matthew A. Williams, Kenneth C. Cundy, Lijun Zhang, Clive Sweet, Norbert Bischofberger, Kenneth J. Jakeman, Willard Lew, Paul A. Escarpe
Publikováno v:
Antimicrobial Agents and Chemotherapy. 42:647-653
GS 4071 is a potent carbocyclic transition-state analog inhibitor of influenza virus neuraminidase with activity against both influenza A and B viruses in vitro. GS 4116, the guanidino analog of GS 4071, is a 10-fold more potent inhibitor of influenz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e687a8b9f3e3a6d4abc859716f81cd5
https://doi.org/10.1128/aac.42.3.647
https://doi.org/10.1128/aac.42.3.647
Publikováno v:
Journal of General Virology. 72:705-709
Fever in influenza results from the release of endogenous pyrogen (EP) following virus-phagocyte interaction and its level correlates with the differing virulence of virus strains. However, the different levels of fever produced in ferrets by intraca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4119cb4d5d576ec3f339ba1d3cb153bb
https://doi.org/10.1099/0022-1317-72-3-705
https://doi.org/10.1099/0022-1317-72-3-705
Autor:
E. Csöregi, Jonathan R. Lloyd, Jon L. Hobman, Nigel L. Brown, Kenneth J. Jakeman, Bo Mattiasson, Ibolya Bontidean
Publikováno v:
Biochemical Society transactions. 26(4)
Introduction Bacteria may carry determinants of resistance to a number of heavy metals, including silver, bismuth, cadmium, cobalt, copper, mercury, lead, nickel, thallium or zinc cations and the oxyanions of arsenic, chromium, antimony, tellurium or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79c669e41e14c50210a5b39a1a4c38e4
https://pubmed.ncbi.nlm.nih.gov/10047802
https://pubmed.ncbi.nlm.nih.gov/10047802
Publikováno v:
The Journal of infectious diseases. 164(5)
The influence of rimantadine-resistance mutations on the virulence of human H3N2 viruses in ferrets was examined. The similarities in virulence of the drug-resistant mutants with single amino acid substitutions at three different locations, 27, 30, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d812520f709c97ef3efec4f0340a798
https://pubmed.ncbi.nlm.nih.gov/1940477
https://pubmed.ncbi.nlm.nih.gov/1940477
Autor:
Sylvia D. Meryon, Kenneth J. Jakeman
Publikováno v:
International Endodontic Journal. 18:191-198
Summary. Zinc at the levels released from several dental restorative materials was toxic to both fibre-blasts and macrophages, and so appears to be an important factor in the cytotoxicity in vitro of these materials. The toxicity of zinc to fibroblas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25eef8579ce4bdb363e2258bf03237fe
https://doi.org/10.1111/j.1365-2591.1985.tb00440.x
https://doi.org/10.1111/j.1365-2591.1985.tb00440.x
Publikováno v:
Microbial pathogenesis. 5(2)
Passive immunization of ferret neonates by colostrally-derived anti-influenza virus IgG did not entirely prevent infection when mothers were immunized with 1 or 2 doses of formalin inactivated vaccine with adjuvant (alhydrogel). Influenza virus repli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bae31f4c105db8f91f8fcabc76f9e67
https://pubmed.ncbi.nlm.nih.gov/3237053
https://pubmed.ncbi.nlm.nih.gov/3237053