Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Kenneth J. Blackburn"'
Autor:
Aileen A. Milne, Roger A. Burges, Michael Gwilt, Kenneth J. Blackburn, Alan J. Higgins, Anne M. Solca
Publikováno v:
European Journal of Pharmacology. 215:137-144
In open chest anaesthetised dogs, dofetilide increased the ventricular effective refractory period over the dose range 1-100 micrograms/kg i.v. and the ventricular fibrillation threshold at doses between 3-100 micrograms/kg and was 80-1000 times more
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::008d2b41d6b1a5ffad14f38fb453b764
https://doi.org/10.1016/0014-2999(92)90021-u
https://doi.org/10.1016/0014-2999(92)90021-u
Autor:
Harris W. Dalrymple, Roger A. Burges, Dickinson Roger Peter, Michael Gwilt, Kenneth J. Blackburn, Alan J. Higgins, Peter Edward Cross
Publikováno v:
Journal of cardiovascular pharmacology. 17(3)
A class III antiarrhythmic agent that preferentially increases the effective refractory period without altering conduction velocity holds considerable promise for the treatment of life-threatening cardiac arrhythmias dependent on a reentrant mechanis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1a757649f89003681a97042fcd1ab02
https://pubmed.ncbi.nlm.nih.gov/1711597
https://pubmed.ncbi.nlm.nih.gov/1711597
Autor:
Kenneth J. Blackburn, S F Campbell, Peter Edward Cross, Alan J. Higgins, Michael Gwilt, Donald G. Gardiner, Roger A. Burges, J K Stubbs
Publikováno v:
Journal of Cardiovascular Pharmacology. 9:110-119
Summary:Amlodipine was twice as potent as nifedipine at inhibiting Ca2 + -induced contractions in depolarised rat aorta (IC50 1.9 nM vs. 4.1 nM) but, unlike nifedipine, displayed a very slow onset of action. Contractions induced by depolarising steps
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::939d1ab483c14fd3a2a6fefc9f2b157d
https://doi.org/10.1097/00005344-198701000-00018
https://doi.org/10.1097/00005344-198701000-00018
Publikováno v:
Biochemical and Biophysical Research Communications. 100:291-296
Summary In isolated rat diaphragms, the stimulation of pyruvate decarboxylation by oxfenicine but not by its metabolite, 4-hydroxyphenylglyoxylate (HPG), was blocked by aminooxyacetate. However, when administered intravenously to fat-fed rats, HPG wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ace4128381b92da387d5ef2e398f348
https://doi.org/10.1016/s0006-291x(81)80095-2
https://doi.org/10.1016/s0006-291x(81)80095-2
Autor:
Kenneth J. Blackburn, Alan J. Higgins
Publikováno v:
Journal of Molecular and Cellular Cardiology. 16:427-438
The direct myocardial protection afforded by three structurally distinct calcium antagonists (0.1 micron nifedipine, 0.1 micron verapamil and 0.4 micron diltiazem), and a calmodulin antagonist (20 micron W-7) was assessed in isolated working rat hear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d90b1dbdd7a98a6b5ce2654df1852ff2
https://doi.org/10.1016/s0022-2828(84)80614-8
https://doi.org/10.1016/s0022-2828(84)80614-8
Autor:
Kenneth J. Blackburn, Mary S. Ghaly, Laurie G. Pullman, Michael L. Hayden, David S. Salsburg, Jay W. Constantine, David Cambridge, Sharat Shevde, Colin R. Taylor, Adeoye Y. Olukotun, Peter F. Moore, Hugh M. McIhenny, James R.C. Baird, Craig Allan Paul Dance Saxton
Publikováno v:
American Heart Journal. 102:515-532
The animal and human pharmacology of several new drugs (prazosin, trimazosin, pirbuterol, and carbazeran) useful in the treatment of congestive heart failure (CHF) is delineated in relation to the pharmacology of other agents employed for CHF managem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d14f5877d973084b23b69ab7d585009
https://doi.org/10.1016/0002-8703(81)90740-7
https://doi.org/10.1016/0002-8703(81)90740-7
Autor:
John Edmund Arrowsmith, Campbell Simon F, J K Stubbs, Roger A. Burges, Donald G. Gardiner, Peter E. Cross, Kenneth J. Blackburn
Publikováno v:
ChemInform. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1aa8201d79e44519bc4bdb6b02bb63a1
https://doi.org/10.1002/chin.198706180
https://doi.org/10.1002/chin.198706180
Autor:
M. G. Page, Alan J. Higgins, Malcolm Morville, Roger A. Burges, Kenneth J. Blackburn, Donald G. Gardiner
Publikováno v:
Life sciences. 27(11)
In isolated diaphragms from rats fed on a high-fat diet, oxfenicine (S-4-hydroxyphenylglycine) stimulated the depressed rates of pyruvate decarboxylation (2-fold) and glucose oxidation (5-fold). In diaphragms from normal-fed rats, oxfenicine had no e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a669906e4969550fd9fcd9d9984247ce
https://pubmed.ncbi.nlm.nih.gov/7432098
https://pubmed.ncbi.nlm.nih.gov/7432098
Autor:
Roger A. Burges, Campbell Simon F, Stubbs John K, Donald G. Gardiner, John Edmund Arrowsmith, Peter Edward Cross, Kenneth J. Blackburn
Publikováno v:
Journal of medicinal chemistry. 29(9)
A series of dihydropyridines substituted at the 2-position by basic side chains are described and their potencies as calcium antagonists listed. One compound, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5- methoxycarbonyl-6-methyl-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3de8faca65574e8d415abd0e8f9929b4
https://pubmed.ncbi.nlm.nih.gov/2943898
https://pubmed.ncbi.nlm.nih.gov/2943898