Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Kenneth J. Barns"'
Autor:
Marc G. Chevrette, Caitlin M. Carlson, Humberto E. Ortega, Chris Thomas, Gene E. Ananiev, Kenneth J. Barns, Adam J. Book, Julian Cagnazzo, Camila Carlos, Will Flanigan, Kirk J. Grubbs, Heidi A. Horn, F. Michael Hoffmann, Jonathan L. Klassen, Jennifer J. Knack, Gina R. Lewin, Bradon R. McDonald, Laura Muller, Weilan G. P. Melo, Adrián A. Pinto-Tomás, Amber Schmitz, Evelyn Wendt-Pienkowski, Scott Wildman, Miao Zhao, Fan Zhang, Tim S. Bugni, David R. Andes, Monica T. Pupo, Cameron R. Currie
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Host microbiomes are feasible sources for drug discovery. Here, using large-scale isolations, bioactivity assays and omics, the authors uncover the antimicrobial potential of insect-associated Streptomyces and identify a compound, cyphomycin, active
Externí odkaz:
https://doaj.org/article/854e622dbc4346adb3d1e484ca48f081
Autor:
Jon Clardy, Kenneth J. Barns, Cameron R. Currie, Tim S. Bugni, David R. Andes, Emily Mevers, Eric J. N. Helfrich, Josep Saurí, Matthew T. Henke
Publikováno v:
Journal of the American Chemical Society
Bacterial symbionts frequently provide chemical defenses for their hosts, and such systems can provide discovery pathways to new antifungals and structurally intriguing metabolites. This report describes a small family of naturally occurring small mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af5c3eac4c972985244b66ec7e28dfb5
http://europepmc.org/articles/PMC6823628
http://europepmc.org/articles/PMC6823628
Publikováno v:
Journal of Natural Products. 82:1930-1934
Here we report the discovery of two new 3-acetamido-4-hydroxybenzoate esters, bulbiferates A (1) and B (2), isolated from Microbulbifer sp. cultivated from the marine tunicate Ecteinascidia turbinata. The structures of 1 and 2 were determined by anal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7806c0173167857436ad8bee17b6a9de
https://doi.org/10.1021/acs.jnatprod.9b00312
https://doi.org/10.1021/acs.jnatprod.9b00312
Autor:
Fan Zhang, Kenneth J. Barns, Hiram Sanchez, Ryley Jones, Anjon Audhya, Robert Zarnowski, Jen Fossen, Tim S. Bugni, Miao Zhao, David R. Andes, Scott R. Rajski
Publikováno v:
J Clin Invest
The emergence of drug-resistant fungi has prompted an urgent threat alert from the US Centers for Disease Control (CDC). Biofilm assembly by these pathogens further impairs effective therapy. We recently identified an antifungal, turbinmicin, that in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98cbd820ae925ec249a625e9789fb698
https://pubmed.ncbi.nlm.nih.gov/33373326
https://pubmed.ncbi.nlm.nih.gov/33373326
Autor:
Jeff S. Piotrowski, Weiping Tang, Justin Nelson, Hiram Sanchez, Fan Zhang, Marc G. Chevrette, Spencer S. Ericksen, Tim S. Bugni, Gene E. Ananiev, Cameron R. Currie, Jen Fossen, David R. Andes, Le Guo, Kenneth J. Barns, Changgui Zhao, Miao Zhao, Ilia A. Guzei, Anjon Audhya, Shaurya Chanana, Scott R. Rajski, Jian Peng, Doug R. Braun
Publikováno v:
Science
Prospecting for antifungal molecules Marine bacteria produce a plethora of natural products that often have unusual chemical structures and corresponding reactivity, which sometimes translate into a valuable biological function. Zhang et al. used a m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::728d14d1589c143bee00bd0d22e5b917
https://pubmed.ncbi.nlm.nih.gov/33311563
https://pubmed.ncbi.nlm.nih.gov/33311563
Autor:
Fan Zhang, David R. Andes, Doug R. Braun, Tim S. Bugni, F. Michael Hoffmann, Kenneth J. Barns
Publikováno v:
Journal of Natural Products. 80:2551-2555
Here we describe the rapid identification and prioritization of novel active marine natural products using an improved dereplication strategy. During the course of our screening of marine natural product libraries, a new cyclic trihydroxamate compoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::629371ee300728598d71b6b289025b3f
https://doi.org/10.1021/acs.jnatprod.7b00328
https://doi.org/10.1021/acs.jnatprod.7b00328
Autor:
Doug R. Braun, Navid Adnani, Yan Zhang, Ilia A. Guzei, Kenneth J. Barns, Shirley Parker-Nance, Tim S. Bugni, Gregory A. Ellis
Publikováno v:
Journal of Natural Products. 79:2968-2972
Despite the fact that actinomycetes harbor the genetic potential to produce terpenes, terpenoid natural products tend to be a rare occurrence in fermentation broths. Here we report two new halimane-type diterpenoids, micromonohalimanes A (1) and B (2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fde218d8d35dca54f7c2c409dd0ca99
https://doi.org/10.1021/acs.jnatprod.6b00555
https://doi.org/10.1021/acs.jnatprod.6b00555
Autor:
Kenneth J. Barns, James C. Weisshaar
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1858:725-732
Alamethicin is a well-studied antimicrobial peptide (AMP) that kills Gram-positive bacteria. It forms narrow, barrel-stave pores in planar lipid bilayers. We present a detailed, time-resolved microscopy study of the sequence of events during the atta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47ea4d6344e8d653ae0596d5de3f1497
https://doi.org/10.1016/j.bbamem.2016.01.003
https://doi.org/10.1016/j.bbamem.2016.01.003
Autor:
Julian Cagnazzo, Camila Carlos, Weilan G. P. Melo, Laura K. Muller, Caitlin M Carlson, Kenneth J. Barns, Amber Schmitz, Fan Zhang, Will Flanigan, Gina R. Lewin, Jennifer J. Knack, Mônica Tallarico Pupo, F. Michael Hoffmann, Gene E. Ananiev, Jonathan L. Klassen, Scott A. Wildman, Marc G. Chevrette, Adam J. Book, Cameron R. Currie, David R. Andes, Kirk J. Grubbs, Heidi A. Horn, Miao Zhao, Evelyn Wendt-Pienkowski, Chris S. Thomas, Tim S. Bugni, Bradon R. McDonald, Humberto E. Ortega, Adrián A. Pinto-Tomás
Publikováno v:
Nature Communications
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature Communications, vol.10(516), pp.1-11
Kérwá
Universidad de Costa Rica
instacron:UCR
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature Communications, vol.10(516), pp.1-11
Kérwá
Universidad de Costa Rica
instacron:UCR
Antimicrobial resistance is a global health crisis and few novel antimicrobials have been discovered in recent decades. Natural products, particularly from Streptomyces, are the source of most antimicrobials, yet discovery campaigns focusing on Strep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdfb9062067b7d75a7c86d32db600118
https://pubmed.ncbi.nlm.nih.gov/30705269
https://pubmed.ncbi.nlm.nih.gov/30705269
Autor:
Somenath Bakshi, Benjamin P. Bratton, James C. Weisshaar, Heejun Choi, Kenneth J. Barns, Nambirajan Rangarajan
Studies of time-dependent drug and environmental effects on single, live bacterial cells would benefit significantly from a permeable, nonperturbative, long-lived fluorescent stain specific to the nucleoids (chromosomal DNA). The ideal stain would no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c27100d04a5a03fe6cdeeac933b7927
https://europepmc.org/articles/PMC4135745/
https://europepmc.org/articles/PMC4135745/
