Zobrazeno 1 - 10
of 713
pro vyhledávání: '"Kenneth J, O'Byrne"'
Autor:
Thais Sobanski, Amila Suraweera, Joshua T. Burgess, Iain Richard, Chee Man Cheong, Keyur Dave, Maddison Rose, Mark N. Adams, Kenneth J. O’Byrne, Derek J. Richard, Emma Bolderson
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Glucose metabolism and DNA repair are fundamental cellular processes frequently dysregulated in cancer. In this study, we define a direct role for the glycolytic Aldolase A (ALDOA) protein in DNA double-strand break (DSB) repair. ALDOA is a
Externí odkaz:
https://doaj.org/article/a81c8e487a144595879ce2d50a37a29b
Autor:
Maddison Rose, Joshua T. Burgess, Chee Man Cheong, Mark N. Adams, Parastoo Shahrouzi, Kenneth J. O’Byrne, Derek J. Richard, Emma Bolderson
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundTriple-negative breast cancer (TNBC) is a sub-classification of breast carcinomas, which leads to poor survival outcomes for patients. TNBCs do not possess the hormone receptors that are frequently targeted as a therapeutic in other cancer
Externí odkaz:
https://doaj.org/article/730fd40bf05e413cbdb093bdcca0200a
Autor:
James A. Fletcher, M.B.B.S., William J. Mullally, MBBCh BAO, Rahul Ladwa, MPhil, Kenneth J. O’Byrne, MD
Publikováno v:
JTO Clinical and Research Reports, Vol 5, Iss 2, Pp 100591- (2024)
ALK gene rearrangements are detected in approximately 3% to 5% of NSCLC. ALK tyrosine kinase inhibitors, such as third-generation lorlatinib, have exhibited remarkable efficacy in ALK-rearranged NSCLC; however, they have been associated with a low in
Externí odkaz:
https://doaj.org/article/2a5c358e7f60423296225103b8e163b7
Autor:
Zachariah P. Schuurs, Alexander P. Martyn, Carl P. Soltau, Sam Beard, Esha T. Shah, Mark N. Adams, Laura V. Croft, Kenneth J. O’Byrne, Derek J. Richard, Neha S. Gandhi
Publikováno v:
Biology, Vol 12, Iss 11, p 1405 (2023)
Human single-stranded DNA binding protein 1 (hSSB1) is critical to preserving genome stability, interacting with single-stranded DNA (ssDNA) through an oligonucleotide/oligosaccharide binding-fold. The depletion of hSSB1 in cell-line models leads to
Externí odkaz:
https://doaj.org/article/487676582ec54863a72b53d556791520
Autor:
Didier Boucher, Ruvini Kariawasam, Joshua Burgess, Adrian Gimenez, Tristan E. Ocampo, Blake Ferguson, Ali Naqi, Graeme J. Walker, Emma Bolderson, Roland Gamsjaeger, Kenneth J. O’Byrne, Liza Cubeddu, Kum Kum Khanna, Derek J. Richard
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Maintenance of genomic stability is critical to prevent diseases such as cancer. As such, eukaryotic cells have multiple pathways to efficiently detect, signal and repair DNA damage. One common form of exogenous DNA damage comes from ultravi
Externí odkaz:
https://doaj.org/article/991568c68db64a919a589c680930eeaa
Publikováno v:
Journal of Molecular Pathology, Vol 2, Iss 4, Pp 306-311 (2021)
Well-differentiated papillary mesothelioma has been renamed well-differentiated papillary mesothelial tumour (WDPMT) in the current WHO classification because all mesotheliomas are now regarded as malignant. WDPMT is now defined as a non-invasive pap
Externí odkaz:
https://doaj.org/article/63abfb6b47dc4a51b6d7c2072fc68204
Autor:
Katrina Kildey, Neha S. Gandhi, Katherine B. Sahin, Esha T. Shah, Eric Boittier, Pascal H. G. Duijf, Christopher Molloy, Joshua T. Burgess, Sam Beard, Emma Bolderson, Amila Suraweera, Derek J. Richard, Kenneth J. O’Byrne, Mark N. Adams
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Kildey et al find that high levels of mitotic regulator CDCA3 correlates with sensitivity to platinum agents in non-small cell lung cancer patients and cell lines. They show that interfering with CDCA3 degradation through CK2 inhibition enhances CDCA
Externí odkaz:
https://doaj.org/article/1fca8dd3265e4aecb2ae8d295b050bfa
Autor:
Amila Suraweera, Neha S. Gandhi, Sam Beard, Joshua T. Burgess, Laura V. Croft, Emma Bolderson, Ali Naqi, Nicholas W. Ashton, Mark N. Adams, Kienan I. Savage, Shu-Dong Zhang, Kenneth J. O’Byrne, Derek J. Richard
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Amila Suraweera et al. use a range of biochemical and in vitro cellular assays to examine the role of the COMMD4 in DNA repair. Their results suggest that COMMD4 interacts with the histone H2A-H2B during repair of double-stranded DNA breaks, thereby
Externí odkaz:
https://doaj.org/article/d6ec5b410c7346699b96af09c2c4016b
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2022)
The proteins within the Poly-ADP Ribose Polymerase (PARP) family encompass a diverse and integral set of cellular functions. PARP1 and PARP2 have been extensively studied for their roles in DNA repair and as targets for cancer therapeutics. Several P
Externí odkaz:
https://doaj.org/article/db829be50e584b89a3fe209587a016bd
Autor:
Maddison Rose, Bond Bai, Ming Tang, Chee Man Cheong, Sam Beard, Joshua T. Burgess, Mark N. Adams, Kenneth J. O’Byrne, Derek J. Richard, Neha S. Gandhi, Emma Bolderson
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Barrier-to-Autointegration Factor 1 (Banf1/BAF) is a critical component of the nuclear envelope and is involved in the maintenance of chromatin structure and genome stability. Banf1 is a small DNA binding protein that is conserved amongst multicellul
Externí odkaz:
https://doaj.org/article/b1de3dd79957471790866e59707c6fb6