Halting the Canadian STRIDER randomised controlled trial of sildenafil for severe, early-onset fetal growth restriction: ethical, methodological, and pragmatic considerations

Autor: Peter von Dadelszen, François Audibert, Emmanuel Bujold, Jeffrey N. Bone, Ash Sandhu, Jing Li, Chirag Kariya, Youkee Chung, Tang Lee, Kelvin Au, M. Amanda Skoll, Marianne Vidler, Laura A. Magee, Bruno Piedboeuf, Philip N. Baker, Sayrin Lalji, Kenneth I. Lim

Publikováno v: BMC Research Notes, Vol 15, Iss 1, Pp 1-6 (2022)

Abstract Objectives To determine the efficacy and safety of sildenafil citrate to improve outcomes in pregnancies complicated by early-onset, dismal prognosis, fetal growth restriction (FGR). Eligibility: women ≥ 18 years, singleton, 18 + 0–27 +

Externí odkaz: https://doaj.org/article/0c0f8fba3967412cbeb3d9e163b0b6f5

Association between gestational weight gain and severe adverse birth outcomes in Washington State, US: A population-based retrospective cohort study, 2004-2013.

Autor: U Vivian Ukah, Hamideh Bayrampour, Yasser Sabr, Neda Razaz, Wee-Shian Chan, Kenneth I Lim, Sarka Lisonkova

Publikováno v: PLoS Medicine, Vol 16, Iss 12, p e1003009 (2019)

BACKGROUND:Suboptimal weight gain during pregnancy is a potentially modifiable risk factor. We aimed to investigate the association between suboptimal gestational weight gain and severe adverse birth outcomes by pre-pregnancy body mass index (BMI) ca

Externí odkaz: https://doaj.org/article/069f0ddbf46b4da29cd450e797095eba

Directive clinique no 428 : Prise en charge de la grossesse gémellaire bichoriale

Autor: Elad Mei-Dan, Venu Jain, Nir Melamed, Kenneth I. Lim, Amir Aviram, Greg Ryan, Jon Barrett

Publikováno v: Journal of Obstetrics and Gynaecology Canada. 44:835-851.e1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ad20e92f58e7a080b0d03126d1d5666
https://doi.org/10.1016/j.jogc.2022.05.003

STRIDER (Sildenafil TheRapy in dismal prognosis early onset fetal growth restriction): An international consortium of randomised placebo-controlled trials

Autor: Anna David, Eugene Michael Dempsey, Mark Kilby, Louise Kenny, Christian Gluud, Mark Turner, J Mark Ansermino, Christianne De Groot, Paul Clarke, Aris T. Papageorghiou, Elizabeth Draper, Bruno Piedboeuf, Liona C. Poon, Kenneth I. Lim, Wessel Ganzevoort, Glenn Gardener, Christopher McKinlay, Peter Von Dadelszen, Marjon De Boer, Sandra Davidge, Emmanuel Bujold

Publikováno v: Pels, A, Kenny, L C, Alfirevic, Z, Baker, P N, von Dadelszen, P, Gluud, C, Kariya, C T, Mol, B W, Papageorghiou, A T, van Wassenaer-Leemhuis, A G, Ganzevoort, W, Groom, K M 2017, ' STRIDER (Sildenafil TheRapy in dismal prognosis early onset fetal growth restriction): an international consortium of randomised placebo-controlled trials ', BMC Pregnancy and Childbirth, vol. 17, no. 1, pp. 440 . https://doi.org/10.1186/s12884-017-1594-z
BMC Pregnancy and Childbirth, 17(1):440. BioMed Central
BMC Pregnancy and Childbirth, Vol 17, Iss 1, Pp 1-8 (2017)
Pels, A, Kenny, L C, Alfirevic, Z, Baker, P N, von Dadelszen, P, Gluud, C, Kariya, C T, Mol, B W, Papageorghiou, A, van Wassenaer-Leemhuis, A G, Ganzevoort, W, McCowan, L M & international STRIDER Consortium 2017, ' STRIDER (Sildenafil TheRapy in dismal prognosis early onset fetal growth restriction) : An international consortium of randomised placebo-controlled trials ', BMC Pregnancy and Childbirth, vol. 17, no. 1, 440 . https://doi.org/10.1186/s12884-017-1594-z
BMC pregnancy and childbirth, 17(1). BioMed Central
BMC PREGNANCY AND CHILDBIRTH
BMC Pregnancy and Childbirth

Severe, early-onset fetal growth restriction due to placental insufficiency is associated with a high risk of perinatal mortality and morbidity with long-lasting sequelae. Placental insufficiency is the result of abnormal formation and function of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee7d7d01ec456877c1a13a0b458a66fd
https://ueaeprints.uea.ac.uk/id/eprint/77270/

The authors respond

Autor: Sarka Lisonkova, Kenneth I. Lim, Anne R. Synnes

Publikováno v: Canadian Medical Association Journal. 188:1262.1-1262

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fb167627c6a429c78ab7daa1ee4a9b2f
https://doi.org/10.1503/cmaj.1150132