Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Kenneth H. Ngo"'
Publikováno v:
JID Innovations, Vol 3, Iss 6, Pp 100221- (2023)
Nonkeratinocyte cutaneous malignancies, including breast cancer cutaneous metastasis and melanoma in situ, are often poor surgical candidates. Imiquimod (IMQ), a toll-like receptor 7 agonist that activates innate immunity in the skin, is used to trea
Externí odkaz:
https://doaj.org/article/b4c9a45922ea4fc28da9b184d7de4c7b
Autor:
Man Xu, Tyler Teceno, Pasi A. Jänne, Anika E. Adeni, Paul Kirschmeier, Timothy Lopez, Jens Köhler, Emily S. Chambers, Brittaney A Leeper, Mari Kuraguchi, Elena Ivanova, Arrien A. Bertram, Cloud P. Paweletz, Yoshinobu Shiose, Yutong Zhao, C. Yu, Yasuki Kamai, Luke J. Taus, Kenneth H. Ngo, Qing Zeng, Prafulla C. Gokhale, Heidi M. Haikala, Yang Qiu, Pinar O. Eser
Publikováno v:
Cancer Research. 82:130-141
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) are the standard-of-care treatment for EGFR-mutant non–small cell lung cancers (NSCLC). However, most patients develop acquired drug resistance to EGFR TKIs. HER3 is a unique
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97eb73b0d7fd3f08d5d4a81c3ca8a547
https://doi.org/10.1158/0008-5472.can-21-2426
https://doi.org/10.1158/0008-5472.can-21-2426
Autor:
Katherine A. Donovan, Kenneth H. Ngo, Eric S. Wang, Eric S. Fischer, Verano Alyssa, Radosław P. Nowak, Prafulla C. Gokhale, Nathanael S. Gray, Nicholas A. Eleuteri, Patrick H. Lizotte, J Christine Yuan, Hong Yue
Publikováno v:
Nature chemical biology
The zinc finger transcription factor Helios is critical for maintaining the identity, anergic phenotype, and suppressive activity of regulatory T cells. While it is an attractive target to enhance the efficacy of currently approved immunotherapies, n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f870421a3c7c4074c747684f8f8b40ea
https://doi.org/10.1038/s41589-021-00802-w
https://doi.org/10.1038/s41589-021-00802-w
Autor:
Emily S. Chambers, Alwin Schuller, Stephen Wang, Dalia Ercan, Mika Lin, Pınar Özden Eser, Raymond M. Paranal, Nicolas Floc'h, Sangeetha Palakurthi, Alison D. Santucci, Jeffrey J. Okoro, Geoffrey R. Oxnard, Man Xu, Kenneth H. Ngo, Jeanelle Tsai, Ciric To, Lynette M. Sholl, George Q. Daley, Michael Dills, Pavlos Missios, Kesi Michael, Paul D. Smith, Yoonji Eum, Magda Bahcall, Yanan Kuang, David A. Barbie, Masahiko Yanagita, Jennifer C. Heng, Rana Anjum, Prafulla C. Gokhale, Elena Ivanova, Jieun Son, Kshiti Dholakia, Heidi M. Haikala, Darren Cross, Jihyun Choi, Michael J. Poitras, Pasi A. Jänne, Timothy Lopez, Cloud P. Paweletz, Atsuko Ogino
Publikováno v:
Science Translational Medicine. 13
A subset of drug-resistant EGFR -mutant MET -amplified lung cancer switches oncogenic dependence to MET and is treatable with MET inhibitor monotherapy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f7c7b3de9b86168add52ec03c24e84e
https://doi.org/10.1126/scitranslmed.abb3738
https://doi.org/10.1126/scitranslmed.abb3738
Autor:
John D. Strickley, Mary E. Awad, Shadmehr Demehri, Henry W. Nabeta, Joongho Joh, Kenneth H. Ngo, Maryam M. Asgari, Dat Thinh Ha, Tiancheng Li, Tatsuya Hasegawa, Victor A. Neel, Paul A. Bevins, Alfred B. Jenson, Jonathan L. Messerschmidt, Rosalynn M. Nazarian
Publikováno v:
Nature. 575:519-522
Immunosuppression increases the risk of cancers that are associated with viral infection1. In particular, the risk of squamous cell carcinoma of the skin-which has been associated with beta human papillomavirus (β-HPV) infection-is increased by more
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75e911d3a7e4298e43fcfbcf3595bcc8
https://doi.org/10.1038/s41586-019-1719-9
https://doi.org/10.1038/s41586-019-1719-9
Autor:
Trevor J. Cunningham, Jean-Pierre Eliane, Kenneth H. Ngo, Milan J. Anadkat, Amir H. Ameri, Ilana S. Rosman, Amy Musiek, Maia Livneh, Sara Moradi Tuchayi, Thomas Horn, Anniek Zaalberg, Shadmehr Demehri
Publikováno v:
Journal of Investigative Dermatology. 139:62-70
High-risk skin cancer is a rare, but severe, complication associated with discoid lupus erythematosus (DLE). Chronic scar, inflammation, ultraviolet radiation and immunosuppressive medications are proposed explanations for this heightened skin cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a016e772667df6488763032ddd8a26f
https://doi.org/10.1016/j.jid.2018.06.185
https://doi.org/10.1016/j.jid.2018.06.185
Publikováno v:
J Invest Dermatol
Skin provides the first line of physical and immunological defense against the environmental insults. However, the age-related changes in the immune function of the human skin are unclear. Here, we investigated the age-related changes in epidermal La
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab7d91c6144508d4e235a67f2cf6f372
https://europepmc.org/articles/PMC8142052/
https://europepmc.org/articles/PMC8142052/
Autor:
Saami Khalifian, Gabriel E. Molina, Kenneth H. Ngo, Jamie L. Mull, Beverly E. Faulkner-Jones, Shadmehr Demehri, Lu Chen, Peggy A. Wu, Ilana S. Rosman, Lynn A. Cornelius
Importance Extramammary Paget disease (EMPD), a rare intraepithelial adenocarcinoma, poses a therapeutic challenge with high postoperative recurrence rates and a limited number of effective local treatment options. Objective To describe the use and e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::507a42a546d086dde70eb6502e6b3394
https://europepmc.org/articles/PMC6506893/
https://europepmc.org/articles/PMC6506893/
Autor:
Shadmehr Demehri, Jong Ho Park, Richard T. Lee, Tiancheng Li, Amir H. Ameri, Anniek Zaalberg, Mari Mino-Kenudson, Elena Lopez, Kenneth H. Ngo, Sara Moradi Tuchayi, Marco Colonna
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 116(7)
Chronic inflammation's tumor-promoting potential is well-recognized; however, the mechanism underlying the development of this immune environment is unknown. Studying the transition from acute, tumor-suppressive to chronic, tumor-promoting allergic c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c960d2cc9164e6a52d1ef7b001678720
https://pubmed.ncbi.nlm.nih.gov/30696763
https://pubmed.ncbi.nlm.nih.gov/30696763
Autor:
David G. DeNardo, Kenneth H. Ngo, Rasikia Reddy, Sindhu Manivasagam, Shadmehr Demehri, Sara Moradi Tuchayi, Melissa A Meyers, Wayne M. Yokoyama, Trevor J. Cunningham
Publikováno v:
Journal of Clinical Investigation. 126:1458-1470
Advances in the field of cancer immunology, including studies on tumor-infiltrating CD8+ cytotoxic T lymphocytes (CTLs), have led to new immunotherapeutics with proven efficacy against late-stage cancers. However, the antitumor potential of the immun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cd39a4df14e429a220d9c009a755cdf
https://doi.org/10.1172/jci83724
https://doi.org/10.1172/jci83724