A Mechanism for Assembly of Complexes of Vitronectin and Plasminogen Activator Inhibitor-1 from Sedimentation Velocity Analysis

Autor: Daniel A. Lawrence, Peter Schuck, Kenneth H. Minor, Christine R. Schar, Joseph D. Shore, Cynthia B. Peterson, Grant E. Blouse

Publikováno v: Journal of Biological Chemistry. 280:28711-28720

Plasminogen activator inhibitor-1 (PAI-1) and vitronectin are cofactors involved in pathological conditions such as injury, inflammation, and cancer, during which local levels of PAI-1 are increased and the active serpin forms complexes with vitronec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c95c2360aca0e5656977286f355b451
https://doi.org/10.1074/jbc.m500478200

A Model for the Three-Dimensional Structure of Human Plasma Vitronectin from Small-Angle Scattering Measurements

Autor: William T. Heller, Kenneth H. Minor, Anand Mayasundari, Cynthia B. Peterson, Gary W. Lynn

Publikováno v: Biochemistry. 44:565-574

Small-angle X-ray scattering (SAXS) measurements were used to characterize vitronectin, a circulatory protein found in human plasma that functions in regulating cell adhesion and migration, as well as proteolytic cascades that affect blood coagulatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a8152d0c798efc7ef0fe2aa44286ed0
https://doi.org/10.1021/bi048347s

Interactions of plasminogen activator inhibitor-1 with vitronectin involve an extensive binding surface and induce mutual conformational rearrangements

Autor: Kenneth H. Minor, Grant E. Blouse, Cynthia B. Peterson, Jan K. Jensen, Henrik Gårdsvoll, Michael Ploug, Christine R. Schar, Peter A. Andreasen, Daniel M. Dupont, John Y Anagli

Publikováno v: Blouse, G E, Dupont, D M, Schar, C R, Jensen, J K, Minor, K H, Anagli, J Y, Gårdsvoll, H, Ploug, M, Peterson, C B & Andreasen, P A 2009, ' Interactions of plasminogen activator inhibitor-1 with vitronectin involve an extensive binding surface and induce mutual conformational rearrangements ', Biochemistry, vol. 48, no. 8, pp. 1723-35 . https://doi.org/10.1021/bi8017015

In order to explore early events during the association of plasminogen activator inhibitor-1 (PAI-1) with its cofactor vitronectin, we have applied a robust strategy that combines protein engineering, fluorescence spectroscopy, and rapid reaction kin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f36726a9959233bc1a17aa987da6ab3
https://pubmed.ncbi.nlm.nih.gov/19193026

Role of Lys-32 residues in R67 dihydrofolate reductase probed by asymmetric mutations

Autor: Lori G. Stinnett, R. Derike Smiley, Kenneth H. Minor, Stephanie N. Hicks, Elizabeth E. Howell

Publikováno v: The Journal of biological chemistry. 279(45)

R67 dihydrofolate reductase (R67 DHFR) is a novel protein encoded by an R-plasmid that confers resistance to the antibiotic, trimethoprim. This homotetrameric enzyme possesses 222 symmetry, which imposes numerous constraints on the single active site

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::100bf9c43d3d1f351c3cf98973f6d9b9
https://pubmed.ncbi.nlm.nih.gov/15333636

Luminal and basolateral mechanisms involved in the renal tubular uptake of inorganic mercury

Autor: Zalups, Rudolfs K., Minor, Kenneth H.

Publikováno v: Journal of Toxicology & Environmental Health; Sep1995, Vol. 46 Issue 1, p73, 0p