Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Kenneth H. Elstein"'
Autor:
Robert J. Kavlock, Kenneth H. Elstein, Robert M. Zucker, John M. Rogers, Christopher Lau, Mole Ml, Setzer Rw
Publikováno v:
Toxicology and Applied Pharmacology. 146:29-39
5-Fluorouracil (5-FU) is a chemotherapeutic agent known to retard embryonic growth and induce cleft palate and limb deformities. The predominant mechanism underlying its toxic action is thought to be inhibition of thymidylate synthetase (TS), and hen
Autor:
Robert M. Zucker, Kenneth H. Elstein
Publikováno v:
Clinical Immunology Newsletter. 16:101-113
Autor:
Kenneth H. Elstein, Margaret A. Jankowski, George P. Daston, Robert M. Zucker, Kathleen K. Sulik, Carl L. Keen, John M. Rogers, Marie W. Taubeneck
Publikováno v:
Teratology. 52:149-159
Zinc deficiency is teratogenic in all species in which it has been examined. Zinc is an essential component of enzymes involved in DNA synthesis and cell proliferation, and may play an as yet undetermined role in apoptosis. To further our understandi
Autor:
Robert M. Zucker, Christopher Lau, John M. Rogers, Kenneth H. Elstein, Neil Chernoff, Dana L. Shuey
Publikováno v:
Teratology. 48:75-87
Murine erythroleukemic cells (MELC) exposed to 2′-deoxy-5-azacytidine (D-AZA) or to the active cyclophosphamide (CP) metabolites phosphoramide mustard (PAM) and 4-hydroxycyclophosphamide (OHCP) exhibit cell-cycle perturbations similar to those seen
Autor:
A. R. Buckalew, Christopher Lau, Barbara D. Abbott, Robert J. Kavlock, Tina R. Logsdon, Setzer W, Kenneth H. Elstein, Robert M. Zucker
Publikováno v:
Teratology. 47:541-554
5-Fluorouracil (5-FU) inhibits the enzyme thymidylate synthetase (TS) which results in inhibition of DNA synthesis. 5-FU is teratogenic in many species, inducing cleft palate, limb, and tail defects. In the present study, gestation day (GD) 14 embryo
Publikováno v:
Investigational New Drugs. 10:1-15
To investigate the toxicity and mechanism of action of crisnatol (CRS), a new DNA intercalator currently in phase II clinical trials, we analyzed cellular and nuclear flow cytometric (FCM) parameters of murine erythroleukemic cells (MELC) exposed to
Publikováno v:
Cytometry. 13:39-47
We were able to differentiate the morphologically diverse sperm nuclei of four animal species by using an Ortho flow cytometer to detect the forward light scatter from a red (helium-neon) laser. Cytograms depicting the axial light loss and forward re
Publikováno v:
Biochemical Pharmacology. 42:2199-2208
Following recovery from a 4-hr exposure to clinically achievable concentrations of the topoisomerase II inhibitors Adriamycin®, teniposide, or amsacrine or the putative topoisomerase II inhibitor crisnatol, murine erythroleukemic cells remained viab
Publikováno v:
Cytometry. 11:848-851
By adding Teflon tubing to the effluent line of the Ortho 50H analytical cytofluorograph, we were able to increase the sensitivity of fluorescence and scatter detection threefold without compromising resolution. By increasing sheath backpressure (res
Autor:
R. W. Setzer, Dana L. Shuey, John M. Rogers, Robert J. Kavlock, Christopher Lau, Robert M. Zucker, Kenneth H. Elstein, Michael G. Narotsky
Publikováno v:
Toxicology. 102(1-2)
A biologically-based dose-response (BBDR) model is a mathematical description of the biological events leading to expression of a toxic response. As an alternative to current approaches in non-cancer risk assessment, such models will reduce uncertain