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pro vyhledávání: '"Kenneth G. Nelson"'
Autor:
Kenneth G. Nelson, L.Y. Wang
Publikováno v:
Journal of Pharmaceutical Sciences. 67:86-89
An analysis of the disintegration-dissolution sequence of drug release from a tablet leads to a mathematical expression relating disintegration to the dissolution profile of the tablet and the dissolution rate of the primary drug particles in the tab
Autor:
Kenneth G. Nelson, L.Y. Wang
Publikováno v:
Journal of Pharmaceutical Sciences. 66:1758-1761
A method is described for determining the time course of tabled disintegration. It involves a numerical analysis of the experimental dissolution profile of a tablet and the dissolution characteristics of the primary drug particles in the tablet. The
Autor:
Kenneth G. Nelson, K.F. Farng
Publikováno v:
Journal of Pharmaceutical Sciences. 66:1611-1614
The permeation rate of salicylate across a dialysis membrane was studied in the presence of various types of carboxymethylcellulose. The presence of the polymer in the salicylate solution increased the permeation rate of salicylate. The data were ana
Autor:
James C. Cradock, Kenneth G. Nelson, John P. Christopher, Jacqueline Plowman, J. Patrick McGovren, Mercedes Lassus
Publikováno v:
Investigational New Drugs. 2:359-367
Menogaril [menogarol, 7(R)-O-methylnogarol, 7-OMEN] is a new anthracycline agent which was chosen for clinical trials based on: broad spectrum activity against a panel of murine tumors, lower cardiotoxicity than doxorubicin in the chronic rabbit mode
Autor:
Milton O. Pella, Kenneth G. Nelson
Publikováno v:
Science Education. 45:284-293
Autor:
C.A. Bainbridge, Kenneth G. Nelson
Publikováno v:
Journal of Dental Research. 52:318-321
The reaction of stannous fluoride with hydroxyapatite at pH values less than 2 was studied. The X-ray diffraction powder pattern indicates that the major product is SnHPO 4. Chemical analysis corroborated this finding and also indicated a minor amoun
Autor:
Ashok C. Shah, Kenneth G. Nelson
Publikováno v:
Journal of Pharmaceutical Sciences. 69:210-212
Passive drug transport across a membrane involves the resistances in series offered by the membrane and the liquid layer immediately adjacent to it. The liquid layers generally are referred to as unstirred aqueous diffusion layers, suggesting that so
Autor:
Ashok C. Shah, Kenneth G. Nelson
Publikováno v:
Journal of Pharmaceutical Sciences. 66:137-139
Studies were carried out on the permeation rate of butamben through a dimethicone membrane. Under conditions of “aqueous diffusion layer control,” the permeation rate was accurately described by a mathematical model based on convective diffusion
Autor:
Ashok C. Shah, Kenneth G. Nelson
Publikováno v:
Journal of pharmaceutical sciences. 64(9)
A recently introduced drug dissolution rate model based on convective diffusion was evaluated by experimentally determining dissolution rates. Alkyl p-aminobenzoates were used as the test compounds in a dissolution cell which promoted laminar flow of
Autor:
Kenneth G. Nelson
Publikováno v:
Journal of dental research. 57(1)
Solutions of stannous fluoride are reacted with hydroxyapatite and the progress of the reaction is monitored by calcium analysis. The formation of Sn3F3PO4 proceeds faster with an increase in SnF2 concentration and can be further increased by adding