Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Kenneth G. Milne"'
Autor:
Nicole Zitzmann, Pascal Schneider, Michael A. J. Ferguson, Malcolm J. McConville, Kenneth G. Milne, Achim Treumann
Publikováno v:
Europe PubMed Central
University of Dundee
University of Dundee
The monosaccharide D-arabinopyranose has only been found in glycoconjugates of the trypanosomatid parasites Leishmania major, Endotrypanum schaudinni and Crithidia fasciculata. The donor molecule for the relevant arabinosyltransferases is known to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25eb4983bcdab91db66fd939d5136fd3
https://ora.ox.ac.uk/objects/uuid:d6be67fd-8808-4ce3-be6e-01db462fbeeb
https://ora.ox.ac.uk/objects/uuid:d6be67fd-8808-4ce3-be6e-01db462fbeeb
Publikováno v:
Proceedings of the National Academy of Sciences. 99:5884-5889
The tsetse fly-transmitted protozoan parasite Trypanosoma brucei is the causative agent of human African sleeping sickness and the cattle disease Nagana. The bloodstream form of the parasite uses a dense cell-surface coat of variant surface glycoprot
Publikováno v:
Molecular and Biochemical Parasitology. 112:301-304
Publikováno v:
Journal of Biological Chemistry. 275:12503-12508
African trypanosomes are shielded from their hosts' defenses by a coat of variant surface glycoprotein molecules, each of which is attached to the plasma membrane by a glycosylphosphatidylinositol anchor. During the later stages of glycosylphosphatid
Publikováno v:
Journal of Biological Chemistry. 274:1465-1471
The major glycosylphosphatidylinositols (GPIs) in African trypanosomes are glycolipid A, the precursor of the variant surface glycoprotein membrane anchor, and glycolipid C, a species identical to glycolipid A except that it contains an acylated inos
Publikováno v:
Molecular and Biochemical Parasitology. 94:99-112
African trypanosomes have been shown previously to undergo efficient transformation from bloodstream forms to procyclic (insect dwelling) forms in vitro by adding citrate and/or cis-aconitate to the culture medium and lowering incubation temperature
Autor:
Sylvain Cottaz, John S. Brimacombe, Kenneth G. Milne, Michael A. J. Ferguson, Robert A. Field, Wayne J. Masterson
Publikováno v:
Journal of Biological Chemistry. 269:16403-16408
N-Acetylglucosaminylphosphatidylinositol (GlcNAc-PI) de-N-acetylase was solubilized from the bloodstream form of African trypanosomes using Zwittergent 3-14. The solubilized GlcNAc-PI de-N-acetylase was assayed using radiolabeled GlcNAc-PI substrates
Publikováno v:
European Journal of Biochemistry. 208:309-314
A wide variety of eukaryotic membrane proteins are anchored to the cell surface by a covalent linkage to glycosylphosphatidylinositol. One of the best characterised examples is the variant surface glycoprotein of the protozoan parasite, Trypanosoma b
Autor:
Kenneth G. Milne, Maria Lucia S. Güther, Tunhan Chang, Michael A. J. Ferguson, Terry K. Smith
Publikováno v:
The Journal of biological chemistry. 277(51)
The second step of glycosylphosphatidylinositol anchor biosynthesis in all eukaryotes is the conversion of D-GlcNAcalpha1-6-d-myo-inositol-1-HPO(4)-sn-1,2-diacylglycerol (GlcNAc-PI) to d-GlcNalpha1-6-d-myo-inositol-1-HPO(4)-sn-1,2-diacylglycerol by G
Autor:
Kenneth G. Milne, Gerard J. Kleywegt, Terese Bergfors, J.-Y. Zou, Michael A. J. Ferguson, Jens Knudsen, T.A. Jones, D.M.F. van Aalten
Publikováno v:
Journal of molecular biology. 309(1)
Acyl-CoA binding protein (ACBP) maintains a pool of fatty acyl-CoA molecules in the cell and plays a role in fatty acid metabolism. The biochemical properties of Plasmodium falciparum ACBP are described together with the 2.0 A resolution crystal stru