Zobrazeno 1 - 10 of 13 pro vyhledávání: '"Kenneth G. Meecham"'
1
The influence of guanyl nucleotide on agonist and antagonist affinity at guinea-pig CCK-B/gastrin receptors: Binding studies using [3H]PD140376
Autor: N. Suman-Chauhan, Kenneth G. Meecham, M.C. Pritchard, D.R. Hill, John C. Hunter, Geoffrey N. Woodruff, Louise Webdale
Publikováno v: Regulatory Peptides. 65:37-43
The novel radioligand [3H]PD140376 was used to label receptors that bind cholecystokinin (CCK) and related peptides in membranes prepared from guinea-pig brain and gastric glands. Under control conditions, measurements of the apparent affinity of 11
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf5111558387240151dcc57247d3d576
https://doi.org/10.1016/0167-0115(96)00070-5
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2
The rational development of small molecule tachykinin NK3 receptor selective antagonists - the utilisation of a dipeptide chemical library in drug design
Autor: J.M. Eden, J. Hodgson, P. Boden, Ratcliffe Giles S, Alexander T. McKnight, David Christopher Horwell, Martyn Clive Pritchard, Jenny Raphy, N. Suman-Chauhan, John Hughes, Kenneth G. Meecham, Geoffrey N. Woodruff, William Howson
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 4:1679-1684
Boc(S)Phe(S)PheNH2 (1c) was identified from the biological screening of an in-house dipeptide chemical library as a micromolar NK3 receptor selective ligand (IC50=1150nM). This lead structure has subsequently been developed into a series of potent an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e6e6c10a1dbc147fae4d032f7efc0b4b
https://doi.org/10.1016/s0960-894x(00)80360-1
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3
A structure-affinity study of the amino acid side-chains in neurotensin : N and C terminal deletions and Ala-scan
Autor: David C. Rees, Kenneth G. Meecham, Jenny A. Henry, David Christopher Horwell
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 3:949-952
We report a systematic N- and C-terminal deletion and Ala-scan study which quantifies the involvement of each neurotensin amino acid side-chain for the in vitro binding interaction with the neurotensin receptor. The conclusion is that Tyr11 and Leu13
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cfb7bec6c3fb363720ebec09b7d9e434
https://doi.org/10.1016/s0960-894x(00)80698-8
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6
CI-977, a novel and selective agonist for the κ-opioid receptor
Autor: G.E. Leighton, David Christopher Horwell, David C. Rees, J.C. Hunter, S. J. Boyle, John Hughes, Kenneth G. Meecham
Publikováno v: British Journal of Pharmacology. 101:183-189
1. CI-977 is a new, nonpeptide kappa-opioid compound that has been synthesized and its pharmacological properties determined in a series of in vitro and in vivo rodent models. 2. In a radioligand binding studies, with guinea-pig forebrain homogenates
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4abd68ce7bbd85c34cac440dca4b22c
https://doi.org/10.1111/j.1476-5381.1990.tb12110.x
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8
Alterations in airway mechanics, inflammatory biomarkers and lung histopathology in a rat model of allergen-induced airway inflammation
Autor: Stephen Jordan, Kenneth G Meecham, Rachel A Armstrong, David Bell, Jennifer S. Hincks
Publikováno v: Journal of Inflammation (London, England)
The most objective indicator of asthma severity in the clinic is the measurement of reversible airway obstruction by spirometry. We evaluated the effect of antigen challenge on FEV100, FVC and PEF and airway cell infiltrate, cytokine levels and lung
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36547313d06b7e3f529606e8fa15a166
http://europepmc.org/articles/PMC3751007
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9
Relative sensitivity of mice to inhaled ozone and cigarette smoke exposure
Autor: Emma McConnell, Stephen Jordan, Kenneth G Meecham, Rachel A Armstrong, Robert Carrington, Debbie Rodgers
Publikováno v: Journal of Inflammation (London, England)
Inhaled exposure of both the environmental pollutant ozone and cigarette smoke are important risk factors in the development of chronic obstructive pulmonary disease. We assessed the relative pulmonary sensitivity of mice following ozone challenge in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f54924d99f1d4a6442b4b8344713a7e
http://europepmc.org/articles/PMC3750869
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10
Assessment of the time course of chronic inflammation in the murine house dust mite model
Autor: Stephen Jordan, David Lanham, James Cartwright, Robert Carrington, Kenneth G Meecham, Rachel A Armstrong
Publikováno v: Journal of Inflammation (London, England)
House dust mite (HDM) allergens are associated with allergic disorders and the use of this clinically relevant allergen is increasing in animal models. We assessed the chronic inflammatory time course and the anti-inflammatory efficacy of a phosphodi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c7356cbc854b1f978507841e4428f64
http://europepmc.org/articles/PMC3750862
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