Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Kenneth G. Matthews"'
Autor:
Jenny M. Oldham, Kenneth G. Matthews, Mark Thomas, Heather K. Smith, Kim Whiteman, Christopher D. McMahon, Ferenc Jeanplong, Shelley J. Falconer, Trevor Watson, Ryan G. Paul
Publikováno v:
Journal of Endocrinology. 248:207-220
Insulin-like growth factor-1 (IGF1) is crucial for regulating post-natal growth and, along with myostatin (MSTN), regulates muscle size. Here, we sought to clarify the roles of these two genes in regulating sexually dimorphic growth of body and muscl
Autor:
Heather K Smith, Kenneth G Matthews, Jenny M Oldham, Ferenc Jeanplong, Shelley J Falconer, James J Bass, Mônica Senna-Salerno, Jeremy W Bracegirdle, Christopher D McMahon
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94356 (2014)
Skeletal muscles of myostatin null (Mstn(-/-)) mice are more susceptible to atrophy during hind limb suspension (HS) than are muscles of wild-type mice. Here we sought to elucidate the mechanism for this susceptibility and to determine if Mstn(-/-) m
Externí odkaz:
https://doaj.org/article/8a5f4e4b6c694a08806bf26ee71f3e17
Autor:
Ferenc Jeanplong, Shelley J Falconer, Jenny M Oldham, Mark Thomas, Tarra S Gray, Alex Hennebry, Kenneth G Matthews, Frederick C Kemp, Ketan Patel, Carole Berry, Gina Nicholas, Christopher D McMahon
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e81713 (2013)
Myostatin plays a fundamental role in regulating the size of skeletal muscles. To date, only a single myostatin gene and no splice variants have been identified in mammals. Here we describe the splicing of a cryptic intron that removes the coding seq
Externí odkaz:
https://doaj.org/article/4f9ba57ff9a6476e82269b6e474e45fe
Autor:
Marianne S. Elston, John V. Conaglen, Kenneth G. Matthews, Sarina Lim, Christopher D. McMahon, Gerard Devlin
Publikováno v:
Heart, Lung and Circulation. 27:693-701
Background Myostatin inhibits the development of skeletal muscle and regulates the proliferation of skeletal muscle fibroblasts. However, the role of myostatin in regulating cardiac muscle or myofibroblasts, specifically in acute myocardial infarctio
Autor:
Miranda D. Grounds, Jenny M. Oldham, Philip W. Sheard, Jeremy Bracegirdle, Tea Shavlakadze, Carole Berry, Alexander Hennebry, Marta L. Fiorotto, Heather K. Smith, Gina Nicholas, Christopher D. McMahon, Ferenc Jeanplong, Shelley J. Falconer, Trevor Watson, Monica Senna-Salerno, Kenneth G. Matthews
Publikováno v:
Journal of Endocrinology. 234:187-200
Insulin-like growth factors (IGFs) and myostatin have opposing roles in regulating the growth and size of skeletal muscle, with IGF1 stimulating, and myostatin inhibiting, growth. However, it remains unclear whether these proteins have mutually depen
Autor:
Miranda D. Grounds, Hannah G. Radley-Crabb, Trevor Watson, Christopher D. McMahon, Thea Shavlakadze, Kenneth G. Matthews, Philip W. Sheard, Ruth Jinfen Chai, Zoe Soffe
Publikováno v:
Scandinavian Journal of Medicine & Science in Sports. 24:e423-435
The age-related loss of skeletal muscle mass and function is termed sarcopenia and has been attributed to a decline in concentrations of insulin-like growth factor-1 (IGF-1). We hypothesized that constitutively expressed IGF-1 within skeletal muscles
Autor:
Trevor Watson, Ferenc Jeanplong, Shelley J. Falconer, Mark Thomas, Jenny M. Oldham, Kenneth G. Matthews, Christopher D. McMahon
Publikováno v:
Open Journal of Molecular and Integrative Physiology. :127-138
Growth and differentiation factor-11 (GDF-11) is a secreted protein that is closely related to myostatin, a known inhibitor of skeletal muscle development. The role of GDF-11 in regulating skeletal muscle growth remains unclear and the pattern of exp
Autor:
Kenneth G. Matthews, J J Bass, Ferenc Jeanplong, Shelley J. Falconer, Richard J. Wilkins, Heather K. Smith, John V. Conaglen, Christopher D. McMahon, Claire C. Osepchook, David F. Gerrard, Jenny M. Oldham
Publikováno v:
The Journal of Physiology. 587:669-677
Myostatin inhibits myogenesis and there is reduced abundance of the mature protein in skeletal muscles of adult male compared with female mice. This reduction probably occurs after translation, which suggests that it is a regulated mechanism to reduc
Autor:
Carole Berry, Ketan Patel, Jenny M. Oldham, Frederick C. Kemp, Christopher D. McMahon, Mark Thomas, Alex Hennebry, Ferenc Jeanplong, Kenneth G. Matthews, Shelley J. Falconer, Gina Nicholas, Tarra S. Gray
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 12, p e81713 (2013)
PLoS ONE, Vol 8, Iss 12, p e81713 (2013)
Myostatin plays a fundamental role in regulating the size of skeletal muscles. To date, only a single myostatin gene and no splice variants have been identified in mammals. Here we describe the splicing of a cryptic intron that removes the coding seq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::423fb21dfbde6f15833a4e0fb29fa9ef
Autor:
Peter J. Fowke, Gerard Devlin, Ravi Kambadur, John J. Bass, John V. Conaglen, Wayne G. Somers, Kenneth G. Matthews, Mridula Sharma
Publikováno v:
Journal of Cellular Physiology. 180:1-9
Myostatin is a secreted growth and differentiating factor (GDF-8) that belongs to the transforming growth factor-beta (TGF-β) superfamily. Targeted disruption of the myostatin gene in mice and a mutation in the third exon of the myostatin gene in do