Zobrazeno 1 - 10
of 254
pro vyhledávání: '"Kenneth G C Smith"'
Autor:
Arianne C Richard, James E Peters, Natalia Savinykh, James C Lee, Eric T Hawley, Françoise Meylan, Richard M Siegel, Paul A Lyons, Kenneth G C Smith
Publikováno v:
PLoS Genetics, Vol 14, Iss 9, p e1007458 (2018)
Chronic inflammation in inflammatory bowel disease (IBD) results from a breakdown of intestinal immune homeostasis and compromise of the intestinal barrier. Genome-wide association studies have identified over 200 genetic loci associated with risk fo
Externí odkaz:
https://doaj.org/article/09fbce21503c4743add45655a2a7dd61
Autor:
James E Peters, Paul A Lyons, James C Lee, Arianne C Richard, Mary D Fortune, Paul J Newcombe, Sylvia Richardson, Kenneth G C Smith
Publikováno v:
PLoS Genetics, Vol 12, Iss 3, p e1005908 (2016)
Genome-wide association studies (GWAS) have transformed our understanding of the genetics of complex traits such as autoimmune diseases, but how risk variants contribute to pathogenesis remains largely unknown. Identifying genetic variants that affec
Externí odkaz:
https://doaj.org/article/9f697d5620c9410faac765cfc47510cf
Autor:
Emilio Fernandez-Egea, Petra E Vértes, Shaun M Flint, Lorinda Turner, Syed Mustafa, Alex Hatton, Kenneth G C Smith, Paul A Lyons, Edward T Bullmore
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0155631 (2016)
BACKGROUND:Hypothetically, psychotic disorders could be caused or conditioned by immunological mechanisms. If so, one might expect there to be peripheral immune system phenotypes that are measurable in blood cells as biomarkers of psychotic states. M
Externí odkaz:
https://doaj.org/article/314733b1f6ca4ab1956a27bf4ee37dd4
Lipid anti-lipid antibody responses correlate with disease activity in systemic lupus erythematosus.
Autor:
Vojislav Jovanović, Nurhuda Abdul Aziz, Yan Ting Lim, Amanda Ng Ai Poh, Sherlynn Jin Hui Chan, Eliza Ho Xin Pei, Fei Chuin Lew, Guanghou Shui, Andrew M Jenner, Li Bowen, Eoin F McKinney, Paul A Lyons, Michael D Kemeny, Kenneth G C Smith, Markus R Wenk, Paul A Macary
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e55639 (2013)
Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder characterized by broad clinical manifestations including cardiovascular and renal complications with periodic disease flares and significant morbidity and mortality. One of the main
Externí odkaz:
https://doaj.org/article/e9d92f41f9d141d2bcea8a5d77b6f715
Autor:
Yue Gu, Bhuvaneshwari Shunmuganathan, Xinlei Qian, Rashi Gupta, Rebecca S. W. Tan, Mary Kozma, Kiren Purushotorman, Tanusya M. Murali, Nikki Y. J. Tan, Peter R. Preiser, Julien Lescar, Haziq Nasir, Jyoti Somani, Paul A. Tambyah, SCOPE Cohort Study Group, Kenneth G. C. Smith, Laurent Renia, Lisa F. P. Ng, David C. Lye, Barnaby E. Young, Paul A. MacAry
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract The scale and duration of neutralizing antibody responses targeting SARS-CoV-2 viral variants represents a critically important serological parameter that predicts protective immunity for COVID-19. In this study, we describe the development
Externí odkaz:
https://doaj.org/article/274a4fa528b742699ad188ee670b344e
Autor:
Lisa Hurler, Ágnes Szilágyi, Federica Mescia, Laura Bergamaschi, Blanka Mező, György Sinkovits, Marienn Réti, Veronika Müller, Zsolt Iványi, János Gál, László Gopcsa, Péter Reményi, Beáta Szathmáry, Botond Lakatos, János Szlávik, Ilona Bobek, Zita Z. Prohászka, Zsolt Förhécz, Dorottya Csuka, Erika Kajdácsi, László Cervenak, Petra Kiszel, Tamás Masszi, István Vályi-Nagy, Reinhard Würzner, Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID BioResource Collaboration, Paul A. Lyons, Erik J. M. Toonen, Zoltán Prohászka, Stephen Baker, John R. Bradley, Patrick F. Chinnery, Daniel J. Cooper, Gordon Dougan, Ian G. Goodfellow, Ravindra K. Gupta, Nathalie Kingston, Paul J. Lehner, Nicholas J. Matheson, Caroline Saunders, Kenneth G. C. Smith, Charlotte Summers, James Thaventhiran, M. Estee Torok, Mark R. Toshner, Michael P. Weekes, Gisele Alvio, Sharon Baker, Areti Bermperi, Karen Brookes, Ashlea Bucke, Jo Calder, Laura Canna, Cherry Crucusio, Isabel Cruz, Rnalie de Jesus, Katie Dempsey, Giovanni Di Stephano, Jason Domingo, Anne Elmer, Julie Harris, Sarah Hewitt, Heather Jones, Sherly Jose, Jane Kennet, Yvonne King, Jenny Kourampa, Emily Li, Caroline McMahon, Anne Meadows, Vivien Mendoza, Criona O’Brien, Charmain Ocaya, Ciro Pascuale, Marlyn Perales, Jane Price, Rebecca Rastall, Carla Ribeiro, Jane Rowlands, Valentina Ruffolo, Hugo Tordesillas, Phoebe Vargas, Bensi Vergese, Laura Watson, Jieniean Worsley, Julie-Ann Zerrudo, Ariana Betancourt, Georgie Bower, Ben Bullman, Chiara Cossetti, Aloka De Sa, Benjamin J. Dunore, Maddie Epping, Stuart Fawke, Stefan Gräf, Richard Grenfell, Andrew Hinch, Josh Hodgson, Christopher Huang, Oisin Huhn, Kelvin Hunter, Isobel Jarvis, Emma Jones, Maša Josipović, Ekaterina Legchenko, Daniel Lewis, Joe Marsden, Jennifer Martin, Francesca Nice, Ciara O’Donnell, Ommar Omarjee, Marianne Perera, Linda Pointon, Nicole Pond, Nathan Richoz, Nika Romashova, Natalia Savoinykh, Rahul Sharma, Joy Shih, Mateusz Strezlecki, Rachel Sutcliffe, Tobias Tilly, Zhen Tong, Carmen Treacy, Lori Turner, Jennifer Wood, Marta Wylot, John Allison, Heather Biggs, Helen Butcher, Daniela Caputo, Debbie Clapham-Riley, Eleanor Dewhurst, Christian Fernandez, Anita Furlong, Barbara Graves, Jennifer Gray, Tasmin Ivers, Emma Le Gresley, Rachel Linger, Mary Kasanicki, Sarah Meloy, Francesca Muldoon, Nigel Ovington, Sofia Papadia, Christopher J. Penkett, Isabel Phelan, Venkatesh Ranganath, Jennifer Sambrook, Katherine Schon, Hannah Stark, Kathleen E. Stirrups, Paul Townsend, Julie von Ziegenweidt, Jennifer Webster, Ali Asaripour, Lucy Mwaura, Caroline Patterson, Gary Polwarth, Katherine Bunclark, Michael Mackay, Alice Michael, Sabrina Rossi, Mayurun Selvan, Sarah Spencer, Cissy Yong, Petra Polgarova
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionWhile complement is a contributor to disease severity in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, all three complement pathways might be activated by the virus. Lectin pathway activation occurs through diff
Externí odkaz:
https://doaj.org/article/766e52fb320d462daa94e2918960d612
Autor:
Benjamin J. Dunmore, Paul D. Upton, Kate Auckland, Romit J. Samanta, CITIID‐NIHR BioResource COVID‐19 Collaboration, The EpiCov Database, Paul A. Lyons, Kenneth G. C. Smith, Stefan Gräf, Charlotte Summers, Nicholas W. Morrell
Publikováno v:
Pulmonary Circulation, Vol 13, Iss 1, Pp n/a-n/a (2023)
Abstract Similar to other causes of acute respiratory distress syndrome, coronavirus disease 2019 (COVID‐19) is characterized by the aberrant expression of vascular injury biomarkers. We present the first report that circulating plasma bone morphog
Externí odkaz:
https://doaj.org/article/6cf8c4a70f85404985b5af34ee39b021
Autor:
Tingyan He, Yu Zhang, Ahmet Ozen, Helen C. Su, Colin L. Sweeney, Elif Karakoc-Aydiner, Harry L. Malech, Zinan Zhang, Deniz Ertem, Safa Baris, Helen F. Matthews, Kenneth G. C. Smith, Claudia Gonzaga-Jauregui, Yikun Yao, Michael J. Lenardo
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Interleukin (IL)-37, an antiinflammatory IL-1 family cytokine, is a key suppressor of innate immunity. IL-37 signaling requires the heterodimeric IL-18R1 and IL-1R8 receptor, which is abundantly expressed in the gastrointestinal tract. Here we report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ab16ac2ac84983aa26137b6a65c1c35
Autor:
Amélie Bonaud, Laetitia Gargowitsch, Simon M. Gilbert, Elanchezhian Rajan, Pablo Canales-Herrerias, Daniel Stockholm, Nabila F. Rahman, Mark O. Collins, Hakan Taskiran, Danika L. Hill, Andres Alloatti, Nagham Alouche, Stéphanie Balor, Vanessa Soldan, Daniel Gillet, Julien Barbier, Françoise Bachelerie, Kenneth G. C. Smith, Julia Jellusova, Pierre Bruhns, Sebastian Amigorena, Karl Balabanian, Michelle A. Linterman, Andrew A. Peden, Marion Espéli
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2023, 120 (2), pp.e2213056120. ⟨10.1073/pnas.2213056120⟩
Proceedings of the National Academy of Sciences of the United States of America, 2023, 120 (2), pp.e2213056120. ⟨10.1073/pnas.2213056120⟩
Despite the essential role of plasma cells in health and disease, the cellular mechanisms controlling their survival and secretory capacity are still poorly understood. Here, we identified the soluble N-ethylmaleimide-sensitive factor attachment prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f62eb6890c17956c3a9822f5a059b5a
https://hal.science/hal-04064289v1/document
https://hal.science/hal-04064289v1/document
Autor:
Lyra O. Randzavola, Paige M. Mortimer, Emma Garside, Elizabeth R. Dufficy, Andrea Schejtman, Georgia Roumelioti, Lu Yu, Mercedes Pardo, Kerstin Spirohn, Charlotte Tolley, Cordelia Brandt, Katherine Harcourt, Esme Nichols, Mike Nahorski, Geoff Woods, James C. Williamson, Shreehari Suresh, John M. Sowerby, Misaki Matsumoto, Celio X.C. Santos, Cher Shen Kiar, Subhankar Mukhopadhyay, Will M. Rae, Gordon J. Dougan, John Grainger, Paul J. Lehner, Michael Calderwood, Jyoti Choudhary, Simon Clare, Anneliese Speak, Giorgia Santilli, Alex Bateman, Kenneth G. C. Smith, Francesca Magnani, David C. Thomas
Publikováno v:
eLife. 11
Peer reviewed: True
EROS (essential for reactive oxygen species) protein is indispensable for expression of gp91phox, the catalytic core of the phagocyte NADPH oxidase. EROS deficiency in humans is a novel cause of the severe immunodeficiency, c
EROS (essential for reactive oxygen species) protein is indispensable for expression of gp91phox, the catalytic core of the phagocyte NADPH oxidase. EROS deficiency in humans is a novel cause of the severe immunodeficiency, c