Zobrazeno 1 - 10
of 174
pro vyhledávání: '"Kenneth G, MacLeod"'
Autor:
Emily J. Judd, Jessica E. Tierney, Brian T. Huber, Scott L. Wing, Daniel J. Lunt, Heather L. Ford, Gordon N. Inglis, Erin L. McClymont, Charlotte L. O’Brien, Ronnakrit Rattanasriampaipong, Weimin Si, Matthew L. Staitis, Kaustubh Thirumalai, Eleni Anagnostou, Marlow Julius Cramwinckel, Robin R. Dawson, David Evans, William R. Gray, Ethan L. Grossman, Michael J. Henehan, Brittany N. Hupp, Kenneth G. MacLeod, Lauren K. O’Connor, Maria Luisa Sánchez Montes, Haijun Song, Yi Ge Zhang
Publikováno v:
Scientific Data, Vol 9, Iss 1, Pp 1-38 (2022)
Abstract Paleotemperature proxy data form the cornerstone of paleoclimate research and are integral to understanding the evolution of the Earth system across the Phanerozoic Eon. Here, we present PhanSST, a database containing over 150,000 data point
Externí odkaz:
https://doaj.org/article/eb7317ab4dfc4f0f8443ce579400f6ff
Autor:
Kate M. Moore, Vera Cerqueira, Kenneth G. MacLeod, Peter Mullen, Richard L. Hayward, Simon Green, David J. Harrison, David A. Cameron, Simon P. Langdon
Publikováno v:
Exploration of Targeted Anti-tumor Therapy, Vol 3, Iss 1, Pp 97-116 (2022)
Aim: A model of progressively endocrine-resistant breast cancer was investigated to identify changes that can occur in signaling pathways after endocrine manipulation. Methods: The MCF7 breast cancer model is sensitive to estrogens and anti-estrog
Externí odkaz:
https://doaj.org/article/1befcc865c8d466aa9837be2e933674b
Autor:
Marin Kuntic, Ivana Kuntic, Roopesh Krishnankutty, Adrian Gericke, Matthias Oelze, Tristan Junglas, Maria Teresa Bayo Jimenez, Paul Stamm, Margaret Nandudu, Omar Hahad, Karin Keppeler, Steffen Daub, Ksenija Vujacic-Mirski, Sanela Rajlic, Lea Strohm, Henning Ubbens, Qi Tang, Subao Jiang, Yue Ruan, Kenneth G. Macleod, Sebastian Steven, Thomas Berkemeier, Ulrich Pöschl, Jos Lelieveld, Hartmut Kleinert, Alex von Kriegsheim, Andreas Daiber, Thomas Münzel
Publikováno v:
Redox Biology, Vol 59, Iss , Pp 102580- (2023)
Worldwide, up to 8.8 million excess deaths/year have been attributed to air pollution, mainly due to the exposure to fine particulate matter (PM). Traffic-related noise is an additional contributor to global mortality and morbidity. Both health risk
Externí odkaz:
https://doaj.org/article/a3483da95ed34c90ad76ad47abd956f7
Autor:
Adam Byron, Stephan Bernhardt, Bérèngere Ouine, Aurélie Cartier, Kenneth G. Macleod, Neil O. Carragher, Vonick Sibut, Ulrike Korf, Bryan Serrels, Leanne de Koning
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Abstract Reverse-phase protein array (RPPA) technology uses panels of high-specificity antibodies to measure proteins and protein post-translational modifications in cells and tissues. The approach offers sensitive and precise quantification of large
Externí odkaz:
https://doaj.org/article/07e3b471ccaf448185223b213fb7f35a
Autor:
Ralitsa R. Madsen, James Longden, Rachel G. Knox, Xavier Robin, Franziska Völlmy, Kenneth G. Macleod, Larissa S. Moniz, Neil O. Carragher, Rune Linding, Bart Vanhaesebroeck, Robert K. Semple
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 3 (2021)
Activating PIK3CA mutations are known ‘drivers’ of human cancer and developmental overgrowth syndromes. We recently demonstrated that the ‘hotspot’ PIK3CAH1047R variant exerts unexpected allele dose-dependent effects on stemness in human plur
Externí odkaz:
https://doaj.org/article/4ea0653e3583469b906fa71a429c3620
Autor:
Matthew M. Jones, Bradley B. Sageman, David Selby, Andrew D. Jacobson, Sietske J. Batenburg, Laurent Riquier, Kenneth G. MacLeod, Brian T. Huber, Kara A. Bogus, Maria Luisa G. Tejada, Junichiro Kuroda, Richard W. Hobbs
Publikováno v:
Nature Geoscience. 16:169-174
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46994a8abb9ea7514a1771074f548d9d
https://doi.org/10.1038/s41561-022-01115-w
https://doi.org/10.1038/s41561-022-01115-w
Autor:
Maria Rose Petrizzo, Giulia Amaglio, Erik Wolfgring, David K. Watkins, Kenneth G. MacLeod, Brian T. Huber, Takashi Hasegawa
Oceanic Anoxic Event 2 (OAE 2), spanning the Cenomanian/Turonian boundary (93.9 Ma) was an episode of major perturbations in the global carbon cycle with a δ13C excursion of 2-3‰ documented worldwide. To investigate the response of biota to OAE 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a3ead69e81fd097d0babb9bd99f7e8b
https://doi.org/10.5194/egusphere-egu23-7874
https://doi.org/10.5194/egusphere-egu23-7874
Autor:
Alicja Wudarska, Michael Wiedenbeck, Ewa Słaby, Małgorzata Lempart‐Drozd, Chris Harris, Michael M. Joachimski, Christophe Lécuyer, Kenneth G. MacLeod, Andreas Pack, Torsten Vennemann, Frédéric Couffignal, Dingsu Feng, Johannes Glodny, Christof Kusebauch, Sathish Mayanna, Alexander Rocholl, Laura Speir, Yadong Sun, Franziska D. H. Wilke
Publikováno v:
Geostandards and Geoanalytical Research, vol. 46, no. 2, pp. 277-306
Geostandards and Geoanalytical Research
Geostandards and Geoanalytical Research
Here we report on the oxygen isotope compositions of four proposed apatite reference materials (chlorapatite MGMH#133648 and fluorapatite specimens MGMH#128441A, MZ-TH, and ES-MM). The samples were initially screened for 18O/16O homogeneity using sec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d4870e8b53134d2d5a23160f4f18125
https://doi.org/10.1111/ggr.12416
https://doi.org/10.1111/ggr.12416
Autor:
Asier Unciti-Broceta, Neil O. Carragher, Valerie G. Brunton, Bin-Zhi Qian, Margaret C. Frame, Mark J. Arends, Maria Lopalco, Christina Schoenherr, Henry Beetham, Craig Fraser, Juan R. Luque-Ortega, Rafael Contreras-Montoya, Alison F. Munro, Teresa Valero, Kenneth G. Macleod, Morwenna Muir, John C. Dawson, Xue-Feng Li, Emily R. Webb, Daniel Lietha, Carolin Temps
Despite the approval of several multikinase inhibitors that target SRC and the overwhelming evidence of the role of SRC in the progression and resistance mechanisms of many solid malignancies, inhibition of its kinase activity has thus far failed to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92e862f8d441136de23e083b6c89a273
https://doi.org/10.1158/0008-5472.c.6513090.v1
https://doi.org/10.1158/0008-5472.c.6513090.v1
Autor:
Asier Unciti-Broceta, Neil O. Carragher, Valerie G. Brunton, Bin-Zhi Qian, Margaret C. Frame, Mark J. Arends, Maria Lopalco, Christina Schoenherr, Henry Beetham, Craig Fraser, Juan R. Luque-Ortega, Rafael Contreras-Montoya, Alison F. Munro, Teresa Valero, Kenneth G. Macleod, Morwenna Muir, John C. Dawson, Xue-Feng Li, Emily R. Webb, Daniel Lietha, Carolin Temps
Supplementary Data from A Conformation Selective Mode of Inhibiting SRC Improves Drug Efficacy and Tolerability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f536ea2ccfc4256e470e9896ed6057b
https://doi.org/10.1158/0008-5472.22428648.v1
https://doi.org/10.1158/0008-5472.22428648.v1