Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Kenneth G, Carson"'
Autor:
Isabelle R. Taylor, Bonnie L. Bassler, Brad R. Henke, Julie S Valastyan, Graham A B Hone, Michael R Tota, Chari D. Smith, Kenneth G Carson, Vasiliki Stergioula
Publikováno v:
ACS Chemical Biology. 15:446-456
Pseudomonas aeruginosa is a leading cause of hospital-acquired infections in the United States. PqsE, a thioesterase enzyme, is vital for virulence of P. aeruginosa, making PqsE an attractive target for inhibition. Neither the substrate nor the produ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec0df9c377fa8448e1502c59d2f79b6a
https://doi.org/10.1021/acschembio.9b00905
https://doi.org/10.1021/acschembio.9b00905
Autor:
Konstantin V Salojin, Brian D Hamman, Wei Chun Chang, Kanchan G Jhaver, Amin Al-Shami, Jeannette Crisostomo, Carrie Wilkins, Ann Marie Digeorge-Foushee, Jason Allen, Nita Patel, Suma Gopinathan, Julia Zhou, Amr Nouraldeen, Theodore C Jessop, Jeffrey T Bagdanoff, David J Augeri, Robert Read, Peter Vogel, Jonathan Swaffield, Alan Wilson, Kenneth A Platt, Kenneth G Carson, Alan Main, Brian P Zambrowicz, Tamas Oravecz
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e98151 (2014)
Mammalian sterile 20-like kinase 1 (Mst1) is a MAPK kinase kinase kinase which is involved in a wide range of cellular responses, including apoptosis, lymphocyte adhesion and trafficking. The contribution of Mst1 to Ag-specific immune responses and a
Externí odkaz:
https://doaj.org/article/1dff52e3692941429b8b20d7536589fd
Autor:
Julie S, Valastyan, Michael R, Tota, Isabelle R, Taylor, Vasiliki, Stergioula, Graham A B, Hone, Chari D, Smith, Brad R, Henke, Kenneth G, Carson, Bonnie L, Bassler
Publikováno v:
ACS Chem Biol
Pseudomonas aeruginosa is a leading cause of hospital-acquired infections in the United States. PqsE, a thioesterase enzyme, is vital for virulence of P. aeruginosa, making PqsE an attractive target for inhibition. Neither the substrate nor the produ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6c0a269e6ad13ba641c509da936eed13
https://pubmed.ncbi.nlm.nih.gov/31880429
https://pubmed.ncbi.nlm.nih.gov/31880429
Autor:
Geraldine C Harriman, Fang Wang, Yilin Qi, R Aldrin Denny, Graham A B Hone, Jun Kuai, Kenneth G. Carson, Yingzhi Bi, Rajiv Govindaraj, Deborah Conrady
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundImmunotherapies aiming to boost anti-tumor cell responses in cancer patients has been proven successful by checkpoint inhibitors targeting PD1 or CTLA-4, but the majority of cancer patients do not garner durable benefit. Co-stimulation thro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ccbece57a9b09ee2e3eb39c29c56e14
https://doi.org/10.1136/jitc-2021-sitc2021.864
https://doi.org/10.1136/jitc-2021-sitc2021.864
Autor:
Suma Gopinathan, Kenneth G. Carson, Alan G. E. Wilson, Zhi-Ming Ding, Bryce Alden Harrison, Damaris S. Diaz, Angela L. Harris, Debra Bruce, Nicole Cathleen Goodwin, Emily O’Neill, David R. Powell, Melinda Smith, Eric Strobel, David B. Rawlins, Wendy Xiong, Ling Li, Andrea Y. Thompson, Mary Thiel, Faika Mseeh
Publikováno v:
Journal of Medicinal Chemistry. 60:710-721
The increasing number of people afflicted with diabetes throughout the world is a major health issue. Inhibitors of the sodium-dependent glucose cotransporters (SGLT) have appeared as viable therapeutics to control blood glucose levels in diabetic pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8541b1a58e42776d5a5b4773e40351f7
https://doi.org/10.1021/acs.jmedchem.6b01541
https://doi.org/10.1021/acs.jmedchem.6b01541
Autor:
James E. Grace, Brian Zambrowicz, Pradeep Vattikundala, Kenneth G. Carson, Jonathan Lippy, Clotilde Bourin, Alan Main, Alan Wilson, Sreenivasulu Naidu, Sandhya Mandlekar, Carolyn Diane Dzierba, Saravanan Elavazhagan, Walter Kostich, Gauri Shankar, Jeffrey M. Brown, Charles M. Conway, Charles F. Albright, Justin Vijay Louis, Yu-Wen Li, Vivek Sharma, Yanling Huang, Laszlo Kiss, Amr Nouraldeen, Susheel J. Nara, Martin A. Lewis, Ryan Westphal, Vinay K. Holenarsipur, Anand Balakrishnan, Amy Easton, Robert Zaczek, Jonathan C. Swaffield, Ted Molski, Rick L. Pieschl, Kevin Baker, Katerina Savelieva, Yingzhi Bi, Kenneth S. Santone, Linda J. Bristow, John E. Macor, Jianlin Feng, Guilan Ye, Joanne J. Bronson, Manish Lal Das, Reeba K. Vikramadithyan, Kevin O’Malley, Jason W. Allen, Brian D. Hamman, Michael Gulianello, Yifeng Lu, Thomas H. Lanthorn, Kimberley A. Lentz, Anoop Kumar, Manoj Dokania, Kumaran Dandapani, Rex Denton
Publikováno v:
The Journal of Pharmacology and Experimental Therapeutics
To identify novel targets for neuropathic pain, 3097 mouse knockout lines were tested in acute and persistent pain behavior assays. One of the lines from this screen, which contained a null allele of the adapter protein-2 associated kinase 1 (AAK1) g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04b1480bd30607a9fe64d0e01fbd6b27
http://europepmc.org/articles/PMC4998676
http://europepmc.org/articles/PMC4998676
Autor:
Alan Wilson, Jason P. Healy, Robert Brommage, Xiaolian Xu, Qiang Han, Praveen K. Pabba, Kenneth G. Carson, Gardyan Michael Walter, James M. Schmidt, Andrea Y. Thompson, Ross Mabon, Kristen M. Terranova, Joseph Barbosa, James E. Tarver
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:1184-1187
A group of small molecule thienochromenes inhibitors of Notum Pectinacetylesterase are described. We developed SAR on three series based on carbon, oxygen and sulfur replacement of the 5-position. In each series, highly potent Notum Pectinacetylester
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::990401977cc295fc807cd6291e6f9d8d
https://doi.org/10.1016/j.bmcl.2016.01.038
https://doi.org/10.1016/j.bmcl.2016.01.038
Autor:
Zhi Liang, Alan Wilson, Li Dong, Neil T. Burford, David S. Kimball, Kenneth G. Carson, Yingzhi Bi, Yulian Zhang, Bireshwar Dasgupta, Carolyn Diane Dzierba, Richard A. Hartz, James E. Grace, G. Greg Zipp, Soojin Kwon, Martin A. Lewis, Joanne J. Bronson, Cynthia Anne Fink, Amr Nouraldeen, Saadat Aleem, Giovanni Cianchetta, Jiancheng Wang, Ying Liu, Vijay T. Ahuja, Robert L. Bertekap, Jianxin Han, Michael Alan Green, Angela Cacace, Godwin Kumi, Yudith Garcia, Ying Qiao, Meredith Ferrante, John E. Macor, Ryan Westphal
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:1448-1452
Small molecule modulators of GPR88 activity (agonists, antagonists, or modulators) are of interest as potential agents for the treatment of a variety of psychiatric disorders including schizophrenia. A series of phenylglycinol and phenylamine analogs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16bf15e7cd2cc6067dbe9746466df095
https://doi.org/10.1016/j.bmcl.2015.01.036
https://doi.org/10.1016/j.bmcl.2015.01.036
Autor:
Alan Wilson, Angela L. Harris, Brian Zambrowicz, Wendy Xiong, Christopher M. DaCosta, David R. Powell, Bryce Alden Harrison, Nicole Cathleen Goodwin, Melinda Smith, Sabrina Jeter-Jones, Andrea Y. Thompson, Eric Strobel, Faika Mseeh, David B. Rawlins, Jennifer Greer, Deon Doree, Suma Gopinathan, Kenneth G. Carson, Zhi-Ming Ding
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 362(1)
LX2761 is a potent sodium/glucose cotransporter 1 inhibitor restricted to the intestinal lumen after oral administration. Studies presented here evaluated the effect of orally administered LX2761 on glycemic control in preclinical models. In healthy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38140540d80f7939267c966c2d73c1da
https://pubmed.ncbi.nlm.nih.gov/28442582
https://pubmed.ncbi.nlm.nih.gov/28442582
Autor:
Wei He, Kenneth G. Carson, Victoria K. Lombardo, Praveen K. Pabba, James E. Tarver, Qiang Han, Alan Wilson, James M. Schmidt, Robert Brommage, Gardyan Michael Walter, Andrea Y. Thompson, Joseph Barbosa
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(6)
A group of small molecule thienopyrimidine inhibitors of Notum Pectinacetylesterase are described. We explored both 2-((5,6-thieno[2,3-d]pyrimidin-4-yl)thio)acetic acids and 2-((6,7-thieno[3,2-d]pyrimidin-4-yl)thio)acetic acids. In both series, highl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f993b0f26061479736dc8a0b504f7173
https://pubmed.ncbi.nlm.nih.gov/26897593
https://pubmed.ncbi.nlm.nih.gov/26897593