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pro vyhledávání: '"Kenneth E. Rousch"'
Autor:
Kenneth E. Rousch, Brian W. Jones, Wei-Zhu Zhong, Kathleen J. Cook, Marta G. Williams, Terri L. VandeGiessen
Publikováno v:
Pharmaceutical Research. 11:1524-1529
A multiple cannulated rat model was utilized to investigate the relative contribution of the gut and liver as sites of first-pass metabolism of orally administered U-54494 A, an anticonvulsant drug candidate. Each rat received a dose of U-54494 A by