Výsledky vyhledávání - "Kenneth E. Murray"

Formation of the factory matrix is an important, though not a sufficient function of nonstructural protein μNS during reovirus infection

Autor: Max L. Nibert, Michelle M. Arnold, Kenneth E. Murray

Publikováno v: Virology. 375:412-423

Genome replication of mammalian orthoreovirus (MRV) occurs in cytoplasmic inclusion bodies called viral factories. Nonstructural protein microNS, encoded by genome segment M3, is a major constituent of these structures. When expressed without other v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bb3dd6776d5c06da1ceb222bf6b9a9b
https://doi.org/10.1016/j.virol.2008.02.024

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Guanidine Hydrochloride Inhibits Mammalian Orthoreovirus Growth by Reversibly Blocking the Synthesis of Double-Stranded RNA

Autor: Max L. Nibert, Kenneth E. Murray

Publikováno v: Journal of Virology. 81:4572-4584

Millimolar concentrations of guanidine hydrochloride (GuHCl) are known to inhibit the replication of many plant and animal viruses having positive-sense RNA genomes. For example, GuHCl reversibly interacts with the nucleotide-binding region of poliov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab5d6316da1dc0683c41fe60cedb53db
https://doi.org/10.1128/jvi.02106-06

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Replication of Poliovirus RNA with Complete Internal Ribosome Entry Site Deletions

Autor: Benjamin P. Steil, David J. Barton, Kenneth E. Murray, Allan W. Roberts

Publikováno v: Journal of Virology. 78:1393-1402

cis -acting RNA sequences and structures in the 5′ and 3′ nontranslated regions of poliovirus RNA interact with host translation machinery and viral replication proteins to coordinately regulate the sequential translation and replication of polio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78b161e885370bbc29f883ec6397a227
https://doi.org/10.1128/jvi.78.3.1393-1402.2004

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Poliovirus CRE-Dependent VPg Uridylylation Is Required for Positive-Strand RNA Synthesis but Not for Negative-Strand RNA Synthesis

Autor: Kenneth E. Murray, David J. Barton

Publikováno v: Journal of Virology. 77:4739-4750

The cis -acting replication element (CRE) is a 61-nucleotide stem-loop RNA structure found within the coding sequence of poliovirus protein 2C. Although the CRE is required for viral RNA replication, its precise role(s) in negative- and positive-stra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b307f5fea50079fed9892c4613bd436b
https://doi.org/10.1128/jvi.77.8.4739-4750.2003

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Poliovirus 5′-Terminal Cloverleaf RNA Is Required in cis for VPg Uridylylation and the Initiation of Negative-Strand RNA Synthesis

Autor: Allan W. Roberts, Traci R. Lyons, Kenneth E. Murray, David J. Barton

Publikováno v: Journal of Virology

Chimeric poliovirus RNAs, possessing the 5′ nontranslated region (NTR) of hepatitis C virus in place of the 5′ NTR of poliovirus, were used to examine the role of the poliovirus 5′ NTR in viral replication. The chimeric viral RNAs were incubate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8824ce782805d0f3e5cc748f8eb4d46a
https://doi.org/10.1128/jvi.75.22.10696-10708.2001

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The mammalian orthoreovirus bicistronic M3 mRNA initiates translation using a 5' end-dependent, scanning mechanism that does not require interaction of 5'-3' untranslated regions

Autor: Kenneth E. Murray, Vidya Sagar

Publikováno v: Virus research. 183

Mammalian orthoreovirus mRNAs possess short 5′ UTR, lack 3′ poly(A) tails, and may lack 5′ cap structures at late times post-infection. As such, the mechanisms by which these viral mRNAs recruit ribosomes remain completely unknown. Toward addre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::467454ef33ae9886ef1584381779459d
https://pubmed.ncbi.nlm.nih.gov/24486484

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Nucleoside and RNA triphosphatase activities of orthoreovirus transcriptase cofactor mu2

Autor: John S. L. Parker, Jonghwa Kim, Max L. Nibert, Kenneth E. Murray

Publikováno v: The Journal of biological chemistry. 279(6)

The mammalian Orthoreovirus (mORV) core particle is an icosahedral multienzyme complex for viral mRNA synthesis and provides a delimited system for mechanistic studies of that process. Previous genetic results have identified the mORV mu2 protein as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66da8b4136cc5537cf48ed7e19b9c087
https://pubmed.ncbi.nlm.nih.gov/14613938

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Poly(rC) binding proteins mediate poliovirus mRNA stability

Autor: Kenneth E. Murray, Allan W. Roberts, David J. Barton

Publikováno v: RNA (New York, N.Y.). 7(8)

The 5'-terminal 88 nt of poliovirus RNA fold into a cloverleaf RNA structure and form ribonucleoprotein complexes with poly(rC) binding proteins (PCBPs; AV Gamarnik, R Andino, RNA, 1997, 3:882-892; TB Parsley, JS Towner, LB Blyn, E Ehrenfeld, BL Seml

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21708161ff04421e71755a71de8b1d68
https://pubmed.ncbi.nlm.nih.gov/11497431

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