Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Kenneth E. Eakins"'
Publikováno v:
Prostaglandins. 20:411-418
A number of hydroperoxy (HPETE) and hydroxy (HETE) products of the lipoxygenase pathway of arachidonic acid metabolism are chemotactic and chemokinetic for human neutrophils. We have investigated the relative chemokinetic potency of some of these pro
Publikováno v:
Experimental Eye Research. 19:141-146
We have studied the ability of ocular tissues to metabolize prostaglandin E 1 (PGE 1 ) in vitro and compared this activity with other tissues such as the lung and kidney under standard conditions of temperature, pH and substrate concentrations. Much
Autor:
Kenneth E. Eakins, P.S. Kulkarni
Publikováno v:
British Journal of Pharmacology. 60:135-140
1 Sodium p-benzyl-4-[1-oxo-2-(4-chlorobenzyl)-3-phenyl propyl]phenyl phosphonate (N-0164) selectively inhibited the formation of thromboxane-A2 from prostaglandin endoperoxides by human platelet microsomes in a dose-dependent manner (IC50 2.2 × 10-5
Autor:
Kenneth E. Eakins, P. Bhattacherjee
Publikováno v:
Experimental Eye Research. 27:649-653
The plant alkaloids, colchicine and vinblastine were studied for their effects on rabbit intraocular pressure. Both colchicine and vinblastine administered either topically or by intravitreal injection lowered intraocular pressure in a dose-dependent
Publikováno v:
European Journal of Pharmacology. 66:81-86
Some non-steroid anti-inflammatory drugs which inhibit arachidonate cyclo-oxygenease have been examined for their effects on leukocyte migration, prostaglandin production and oedema formation in carrageenin-induced inflammation in the rat. At doses w
Publikováno v:
Experimental Eye Research. 25:343-351
The rate of reepithelialization of rabbit corneas following partial and complete epithelial denudation was studied by fluorescein staining, photography, and electron microscopy. Partially denuded corneas healed smoothly but some completely denuded co
Publikováno v:
British Journal of Pharmacology. 71:157-164
1 Burimamide selectively inhibited the formation of thromboxane A2 from prostaglandin endoperoxides by human platelet microsomes in a dose-dependent manner (IC50 = 2.5 x 10(-5) M). Burimamide was found to be equipotent to imidazole as a thromboxane s
Autor:
Kenneth E. Eakins, P. Bhattacherjee
Publikováno v:
Prostaglandins. 9:175-182
Topical administration of aqueous solutions of sodium arachidonate to the eyes of rabbits increases intraocular pressure, constricts the pupil and increases both the protein and prostaglandin content of aqueous humor. Arachidonic acid itself dissolve
Publikováno v:
European Journal of Pharmacology. 73:21-28
The effects of arachidonic acid, its cyclo-oxygenase and lipoxygenase products and the synthetic chemotactic peptide, formyl-methionyl-leucyl-phenylalanine (FMLP) on leukocyte accumulation in the aqueous humour and intraocular pressure in the rabbit
Autor:
Kenneth E. Eakins, Prasad S. Kulkarni
Publikováno v:
Prostaglandins. 14:601-605