Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Kenneth E Westerman"'
Publikováno v:
PLoS Genetics, Vol 20, Iss 7, p e1011288 (2024)
We examined the associations of vegetarianism with metabolic biomarkers using traditional and genetic epidemiology. First, we addressed inconsistencies in self-reported vegetarianism among UK Biobank participants by utilizing data from two dietary su
Externí odkaz:
https://doaj.org/article/d9399f1fdfca40e5bb9f1b6d13f6ad81
Autor:
Carlos Alberto Aguilar-Salinas, Clary B Clish, Magdalena del Rocio Sevilla-Gonzalez, Alisa K Manning, Kenneth E Westerman, Amy Deik
Publikováno v:
BMJ Open Diabetes Research & Care, Vol 10, Iss 5 (2022)
Introduction Disentangling the specific factors that regulate glycemia from prediabetes to normoglycemia could improve type 2 diabetes prevention strategies. Metabolomics provides substantial insights into the biological understanding of environmenta
Externí odkaz:
https://doaj.org/article/e25356bd47d04aff8239ba95a6c7c0bc
Autor:
Kenneth E. Westerman, Timothy D. Majarian, Franco Giulianini, Dong-Keun Jang, Jenkai Miao, Jose C. Florez, Han Chen, Daniel I. Chasman, Miriam S. Udler, Alisa K. Manning, Joanne B. Cole
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Understanding how our genes interact with the environment is critical to improving health. Using a large-scale discovery pipeline, here the authors investigate synergies between genetic variants and a broad range of environmental factors impacting ca
Externí odkaz:
https://doaj.org/article/11be228dbd7845c8bdfbc58919ecc035
Publikováno v:
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-8 (2020)
Abstract Background Phytochemicals and other molecules in foods elicit positive health benefits, often by poorly established or unknown mechanisms. While there is a wealth of data on the biological and biophysical properties of drugs and therapeutic
Externí odkaz:
https://doaj.org/article/462b5f5b122f4ba99c75d48f3949b22a
Autor:
Kenneth E. Westerman, Joanna Lin, Magdalena del Rocio Sevilla-Gonzalez, Beza Tadess, Casey Marchek, Alisa K. Manning
Publikováno v:
Frontiers in Genetics, Vol 12 (2022)
Increasing evidence indicates that specific genetic variants influence the severity of outcomes after infection with COVID-19. However, it is not clear whether the effect of these genetic factors is independent of the risk due to more established non
Externí odkaz:
https://doaj.org/article/b55e469b407944208c19d63055bf0149
Autor:
Hyunkyung Kim, Kenneth E. Westerman, Kirk Smith, Joshua Chiou, Joanne B. Cole, Timothy Majarian, Marcin von Grotthuss, Josep M. Mercader, Soo Heon Kwak, Jaegil Kim, Jose C. Florez, Kyle Gaulton, Alisa K. Manning, Miriam S. Udler
Publikováno v:
Diabetologia. 66:495-507
Aims/hypothesisType 2 diabetes (T2D) is highly polygenic and influenced by multiple biological pathways. Rapid expansion in the number of T2D loci can be leveraged to identify such pathways, thus facilitating improved disease management.MethodsWe dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b8c9931d572dbc85c9b6dcf4acabc96
https://doi.org/10.1007/s00125-022-05848-6
https://doi.org/10.1007/s00125-022-05848-6
Autor:
Yuwei Liu, Yu Shen, Tao Guo, Laurence D. Parnell, Kenneth E. Westerman, Caren E. Smith, Jose M. Ordovas, Chao-Qiang Lai
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
Statin is the medication most widely prescribed to reduce plasma cholesterol levels. Yet, how the medication contributes to diabetes risk and impaired glucose metabolism is not clear. This study aims to examine the epigenetic mechanisms of ABCG1 thro
Externí odkaz:
https://doaj.org/article/7d3503a9796542bea710403050a3a914
Summary statistics from genome-wide association studies enable many valuable downstream analyses that are more efficient than individual-level data analysis while also reducing privacy concerns. As growing sample sizes enable better-powered analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb27fc5ac237b5336edc3d3432dd1d13
https://doi.org/10.1101/2023.05.08.23289686
https://doi.org/10.1101/2023.05.08.23289686
Publikováno v:
Frontiers in Genetics. 14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4db5d532b891051e2b5b9919345797c6
Publikováno v:
Frontiers in Genetics. 13
A variety of statistical approaches in nutritional epidemiology have been developed to enhance the precision of dietary variables derived from longitudinal questionnaires. Correlation with biomarkers is often used to assess the relative validity of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd75d3b92f1497c7546f98e5ca9e25ed
https://doi.org/10.3389/fgene.2022.1070511
https://doi.org/10.3389/fgene.2022.1070511