Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Kenneth E Gould"'
Autor:
Kevin Duffin, Kwan Hui, Donetta Gifford-Moore, Xiao-di Huang, Pamela G Rutherford, Nancy K Jackson, John E Hale, Li-Chun Chio, Eugene Zhen, Richard E Higgs, Shuguang Huang, Chung-Wein Lee, Karen Cox, Eileen McCall, Birong Liao, Kenneth E Gould, Mark Rekhter
Publikováno v:
Biomarker Insights, Vol 3, Pp 147-157 (2008)
Background: Current drug therapy of atherosclerosis is focused on treatment of major risk factors, e.g. hypercholesterolemia while in the future direct disease modification might provide additional benefits. However, development of medicines targetin
Externí odkaz:
https://doaj.org/article/c60e5078af034c7d87387ef96cc610fb
Autor:
Birong Liao, Eileen McCall, Karen Cox, Chung-Wein Lee, Shuguang Huang, Richard E Higgs, Li-Chun Chio, Eugene Zhen, John E Hale, Nancy K Jackson, Pamela G Rutherford, Xiao-di Huang, Donetta Gifford-Moore, Kwan Hui, Kevin Duffin, Kenneth E Gould, Mark Rekhter
Publikováno v:
Biomarker Insights, Vol 3 (2008)
Background Current drug therapy of atherosclerosis is focused on treatment of major risk factors, e.g. hypercholesterolemia while in the future direct disease modification might provide additional benefits. However, development of medicines targeting
Externí odkaz:
https://doaj.org/article/77cc1c7dae3b422aab289767ebbbcbd2
Autor:
Joaquim Trias, Patrick I Eacho, Robert M. Christie, Reidy Charles Arthur, Colin Hislop, Heather Fraser, Kenneth E. Gould, Heather L Rick, Michael L Chouinard
Publikováno v:
Journal of Cardiovascular Pharmacology. 53:60-65
The family of secretory phospholipase A2 (sPLA2) enzymes has been associated with inflammatory diseases and tissue injury including atherosclerosis. A-001 is a novel inhibitor of sPLA2 enzymes discovered by structure-based drug design, and A-002 is t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::121b9449ee7d90de5bf7f5eb1ce54ee7
https://doi.org/10.1097/fjc.0b013e318195bfbc
https://doi.org/10.1097/fjc.0b013e318195bfbc
Autor:
Robert M. Christie, J. Michael Kalbfleisch, Ming-Shang Kuo, Donetta Gifford-Moore, Pamela Rutherford, Mark David Rekhter, Kwan Hui, Kenneth E. Gould, Xiao-di Huang
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 6, Pp 1353-1363 (2008)
Sensitive method for chemical analysis of free cholesterol (FC) and cholesterol esters (CE) was developed. Mouse arteries were dissected and placed in chloroform-methanol without tissue grinding. Extracts underwent hydrolysis of cholesteryl esters an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57344a116cd82d5dff8e3a2ecfccb7d7
http://www.sciencedirect.com/science/article/pii/S002222752042379X
http://www.sciencedirect.com/science/article/pii/S002222752042379X
Publikováno v:
Biochemical and Biophysical Research Communications. 332:735-742
Stearoyl-CoA desaturase (SCD) is an integral membrane protein of the endoplasmic reticulum (ER) that catalyzes the formation of monounsaturated fatty acids from saturated fatty acids. Recent studies suggest that SCD is a key regulator of energy metab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f3ae888c6be4b4b7329be09b3a863af
https://doi.org/10.1016/j.bbrc.2005.05.013
https://doi.org/10.1016/j.bbrc.2005.05.013
Autor:
Etai Funk, George E. Taffet, Christie M. Ballantyne, Thuy T. Pham, Mark L. Entman, Justin P. Zachariah, Sherita L. Daniel, Jennifer Pocius, Lloyd H. Michael, Kenneth E. Gould, Craig J. Hartley
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 277:H660-H668
Anatomic and functional changes after either a permanent left anterior descending coronary artery occlusion (PO) or 2 h of occlusion followed by reperfusion (OR) in C57BL/6 mice were examined and compared with those in sham-operated mice. Both interv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9da2cf89a65258f1485de639903122be
https://doi.org/10.1152/ajpheart.1999.277.2.h660
https://doi.org/10.1152/ajpheart.1999.277.2.h660
Publikováno v:
Cardiovascular Pathology. 8:73-80
The purpose of this study was to determine the effects of stent placement on the underlying arterial morphology and the relations of stent-vessel wall interactions with subsequent neointimal formation in an atherosclerotic artery. Seven New Zealand W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccf0e0b5017784dcc6189efe85af928e
https://doi.org/10.1016/s1054-8807(98)00019-2
https://doi.org/10.1016/s1054-8807(98)00019-2
Publikováno v:
Journal of Histotechnology. 18:25-30
The purpose of this study was to identify the optimal staining for cell proliferation in paraffin embedded sections of rabbit and pig ileum. Methods comparing zinc formalin or 10 % buffered formalin, 3 PCNA antibodies (19A2, PC10, MAB424), fixation t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa8ba0ee1cfa168e4e1be85b80724d41
https://doi.org/10.1179/his.1995.18.1.25
https://doi.org/10.1179/his.1995.18.1.25
Autor:
Laura J. Bloem, Philip W. Iversen, Kenneth E. Gould, John N. Lorenz, Xiaohong Yu, Vivek J. Kadambi, Najia Jin, Steve H. Zuckerman, Xushan Wang, Michael E. Christe
Publikováno v:
Journal of molecular and cellular cardiology. 37(3)
Mixed lineage kinase 7 (MLK7) is a recently identified mitogen-activated protein kinase kinase kinase with enriched expression in skeletal muscle and heart. When over-expressed in cardiac myocytes, MLK7 activates both the p38 and c-Jun N-terminal kin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::728ae2f4f37438e38259ef5a196f51cd
https://pubmed.ncbi.nlm.nih.gov/15350844
https://pubmed.ncbi.nlm.nih.gov/15350844
Autor:
Robert M. Christie, Kenneth E. Gould, Craig J. Hartley, Sherita L. Daniel, Mark L. Entman, Damian F. Chaupin, Lloyd H. Michael, Debra L. Konkol, Jennifer Pocius, George E. Sandusky, Justin P. Zachariah, George E. Taffet
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 282(2)
Young mice tolerate myocardial loss after coronary artery ligation (CAL) without congestive heart failure (CHF) signs or mortality. We predicted a CHF phenotype after CAL in aged mice. Left coronary artery ligation produced permanent myocardial infar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::417ba63103944e9e9c39c3f80b3be2f5
https://pubmed.ncbi.nlm.nih.gov/11788410
https://pubmed.ncbi.nlm.nih.gov/11788410