Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Kenneth E Carlson"'
Autor:
Megan M Sperry, Tomiko T Oskotsky, Ivana Marić, Shruti Kaushal, Takako Takeda, Viktor Horvath, Rani K Powers, Melissa Rodas, Brooke Furlong, Mercy Soong, Pranav Prabhala, Girija Goyal, Kenneth E Carlson, Ronald J Wong, Idit Kosti, Brian L Le, James Logue, Holly Hammond, Matthew Frieman, David K Stevenson, Donald E Ingber, Marina Sirota, Richard Novak
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 5, p e1011050 (2023)
Drug repurposing requires distinguishing established drug class targets from novel molecule-specific mechanisms and rapidly derisking their therapeutic potential in a time-critical manner, particularly in a pandemic scenario. In response to the chall
Externí odkaz:
https://doaj.org/article/cfab81f7026e481d8f6ae5a6eade32cd
Autor:
Sheila Ranganath, Ashok Bhandari, Nicole Avitahl-Curtis, Jaimee McMahon, Derek Wachtel, Jenny Zhang, Christopher Leitheiser, Sylvie G Bernier, Guang Liu, Tran T Tran, Herodion Celino, Jenny Tobin, Joon Jung, Hong Zhao, Katie E Glen, Chris Graul, Aliesha Griffin, Wayne C Schairer, Carolyn Higgins, Tammi L Reza, Eva Mowe, Sam Rivers, Sonya Scott, Alex Monreal, Courtney Shea, Greg Bourne, Casey Coons, Adaline Smith, Kim Tang, Ramya A Mandyam, Jaime Masferrer, David Liu, Dinesh V Patel, Angelika Fretzen, Craig A Murphy, G Todd Milne, Mark L Smythe, Kenneth E Carlson
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0141330 (2015)
Interleukin-6 (IL-6) is an important member of the cytokine superfamily, exerting pleiotropic actions on many physiological processes. Over-production of IL-6 is a hallmark of immune-mediated inflammatory diseases such as Castleman's Disease (CD) and
Externí odkaz:
https://doaj.org/article/79b1eaa807e1438c8eaa8708c553dbc5
Autor:
Douglas C McDonald, Kenneth E Carlson
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69241 (2013)
BackgroundAbuse of prescription opioid analgesics is a serious threat to public health, resulting in rising numbers of overdose deaths and admissions to emergency departments and treatment facilities. Absent adequate patient information systems, "doc
Externí odkaz:
https://doaj.org/article/ed09a7f713ab4b33ad985253145a7dad
Autor:
Crystal Yuri Oh, Ilona Golynker, Sarah E. Gilpin, Haiqing Bai, Rachelle Prantil-Baun, Amanda Jiang, Danni Y. Zhu, Steven P. Gygi, Mercy Soong, Melissa Rodas, Marisa McGrath, Longlong Si, Robert Haupt, Seongmin Kim, James Logue, Daniel Blanco-Melo, Tristan X. Jordan, Randy A. Albrecht, Rasmus Møller, Tian Zhang, Donald E. Ingber, Kohei Oishi, Justin J. Frere, Kambez H. Benam, Daisy A. Hoagland, Girija Goyal, Kenneth E. Carlson, Wen-Chun Liu, Rani K. Powers, Shu Horiuchi, Benjamin E. Nilsson-Payant, Skyler Uhl, Roberto Plebani, Matthew B. Frieman, Benjamin R. tenOever, Stuart Weston, Atiq Nurani, Wuji Cao
Publikováno v:
Nature biomedical engineering
The rapid repurposing of antivirals is particularly pressing during pandemics. However, rapid assays for assessing candidate drugs typically involve in vitro screens and cell lines that do not recapitulate human physiology at the tissue and organ lev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45a3db572711b44bb7347a5c830b55e9
https://doi.org/10.1038/s41551-021-00718-9
https://doi.org/10.1038/s41551-021-00718-9
Autor:
Longlong Si, Haiqing Bai, Crystal Yuri Oh, Amanda Jiang, Fan Hong, Tian Zhang, Yongxin Ye, Tristan X. Jordan, James Logue, Marisa McGrath, Chaitra Belgur, Karina Calderon, Atiq Nurani, Wuji Cao, Kenneth E. Carlson, Rachelle Prantil-Baun, Steven P. Gygi, Dong Yang, Colleen B. Jonsson, Benjamin R. tenOever, Matthew Frieman, Donald E. Ingber
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
The current coronavirus disease 2019 (COVID-19) pandemic highlights the need for broad-spectrum antiviral therapeutics. Here we describe a new class of self-assembling immunostimulatory short duplex RNAs that potently induce production of type I and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::348920f3ee6af3e93c3fab78697e8252
https://pubmed.ncbi.nlm.nih.gov/34845453
https://pubmed.ncbi.nlm.nih.gov/34845453
Autor:
George Bakris, Albert T. Profy, Jennifer G. Chickering, Jelena P. Seferovic, John P. Hanrahan, Ian H. de Boer, Michael D. Cressman, Mark G. Currie, James Wakefield, G. Todd Milne, Kenneth E. Carlson, Phebe J. Wilson, Yueh-Tyng Chien
Publikováno v:
Clin J Am Soc Nephrol
Background and objectives Impaired nitric oxide signaling through soluble guanylate cyclase has been implicated in the pathophysiology of diabetic kidney disease. Praliciguat, a soluble guanylate cyclase stimulator that amplifies nitric oxide signali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d5a08796e56d4397df9ed0dd1e1a556
https://doi.org/10.2215/cjn.08410520
https://doi.org/10.2215/cjn.08410520
Autor:
James Logue, Arup R. Chakraborty, Robert Johnson, Girija Goyal, Louis J. Taylor, Lauren Baracco, Marisa E. McGrath, Robert Haupt, Melissa Rodas, Brooke A. Furlong, Mercy Soong, Pranav Prabhala, Viktor Horvath, Kenneth E. Carlson, Stuart Weston, Donald E. Ingber, Melvin L. DePamphilis, Matthew B. Frieman
The ongoing COVID-19 pandemic has claimed more than 6 million lives and continues to test the world economy and healthcare systems. To combat this pandemic, the biological research community has shifted efforts to the development of medical counterme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66c0b407f9cfce5cffaed88bdf9aece6
https://doi.org/10.21203/rs.3.rs-1605065/v1
https://doi.org/10.21203/rs.3.rs-1605065/v1
Autor:
Megan M. Sperry, Tomiko Oskotsky, Ivana Marić, Shruti Kaushal, Takako Takeda, Viktor Horvath, Rani K. Powers, Melissa Rodas, Brooke Furlong, Mercy Soong, Pranav Prabhala, Girija Goyal, Kenneth E. Carlson, Ronald J. Wong, Idit Kosti, Brian L. Le, James Logue, Holly Hammond, Matthew Frieman, David K. Stevenson, Donald E. Ingber, Marina Sirota, Richard Novak
Publikováno v:
medRxiv
PLoS computational biology, vol 19, iss 5
PLoS computational biology, vol 19, iss 5
SummaryImportanceDrug repurposing requires distinguishing established drug class targets from novel molecule-specific mechanisms and rapidly derisking their therapeutic potential in a time-critical manner, particularly in a pandemic scenario. In resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d30e7c259c82c34fff7c6971e0274968
https://pubmed.ncbi.nlm.nih.gov/35441166
https://pubmed.ncbi.nlm.nih.gov/35441166
High-risk and Long-term Opioid Prescribing to Military Spouses in the Millennium Cohort Family Study
Autor:
Carlos E. Carballo, Douglas C. McDonald, Nida H. Corry, Kenneth E. Carlson, Valerie A. Stander, Sharmini Radakrishnan, Alicia C. Sparks
Publikováno v:
Military medicine. 185(9-10)
IntroductionThe use and misuse of opioids by active service members has been examined in several studies, but little is known about their spouses’ opioid use. This study estimates the number of military spouses who received high-risk or long-term o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27c0d4e99a4194d1b61d19077e3968fa
https://pubmed.ncbi.nlm.nih.gov/32696969
https://pubmed.ncbi.nlm.nih.gov/32696969
Autor:
Kambez H. Benam, Shu Horiuchi, Benjamin E. Nilsson-Payant, Kenneth E. Carlson, Matthew B. Frieman, Girija Goyal, Seongmin Kim, Daisy A. Hoagland, Benjamin R. tenOever, Rani K. Powers, Wen-Chun Liu, Randy A. Albrecht, Amanda Jiang, Daniel Blanco-Melo, Danni Y. Zhu, Sarah E. Gilpin, Longlong Si, Melissa Rodas, Robert Haupt, James Logue, Wuji Cao, Kohei Oishi, Tristan X. Jordan, Rasmus Møller, Skyler Uhl, Donald E. Ingber, Haiqing Bai, Marisa McGrath, Rachelle Prantil-Baun, Stuart Weston, Atiq Nurani, Crystal Yuri Oh
The rising threat of pandemic viruses, such as SARS-CoV-2, requires development of new preclinical discovery platforms that can more rapidly identify therapeutics that are activein vitroand also translatein vivo. Here we show that human organ-on-a-ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01f2e51a381d2731522dcdefb8bf13ec
https://doi.org/10.1101/2020.04.13.039917
https://doi.org/10.1101/2020.04.13.039917