Zobrazeno 1 - 10
of 259
pro vyhledávání: '"Kenneth E Bernstein"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 7055 (2024)
Angiotensin converting enzyme (ACE) exerts strong modulation of myeloid cell function independently of its cardiovascular arm. The success of the ACE-overexpressing murine macrophage model, ACE 10/10, in treating microbial infections and cancer opens
Externí odkaz:
https://doaj.org/article/e6ad9f9caee6479faa40af2c6bed3a50
Autor:
DuoYao Cao, Suguru Saito, LiMin Xu, Wei Fan, Xiaomo Li, Faizan Ahmed, Predrag Jovanovic, Tomohiro Shibata, Mingtian Che, Ellen A. Bernstein, Jorge Gianni, Ajit S. Divakaruni, Derick Okwan-Duodu, Zakir Khan, Celine E. Riera, Fanfan Chen, Kenneth E. Bernstein
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The pathogenesis of atherosclerosis is defined by impaired lipid handling by macrophages which increases intracellular lipid accumulation. This dysregulation of macrophages triggers the accumulation of apoptotic cells and chronic inflammation which c
Externí odkaz:
https://doaj.org/article/7c8a952ad81f4988a3c2646c8a32d185
Autor:
Ron Danziger, Dieu-Trang Fuchs, Yosef Koronyo, Altan Rentsendorj, Julia Sheyn, Eric Y. Hayden, David B. Teplow, Keith L. Black, Sebastien Fuchs, Kenneth E. Bernstein, Maya Koronyo-Hamaoui
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
This review examines the role of angiotensin-converting enzyme (ACE) in the context of Alzheimer’s disease (AD) and its potential therapeutic value. ACE is known to degrade the neurotoxic 42-residue long alloform of amyloid β-protein (Aβ42), a pe
Externí odkaz:
https://doaj.org/article/b54ad841e64e40d8a609a58081f4ca5b
Autor:
Hamid Suhail, Hongmei Peng, Jiang Xu, Hani N. Sabbah, Khalid Matrougui, Tang-Dong Liao, Pablo A. Ortiz, Kenneth E. Bernstein, Nour-Eddine Rhaleb
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 3, Iss , Pp 100024- (2023)
Angiotensin-converting enzyme (ACE) hydrolyzes N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) into inactive fragments through its N-terminal site (ACEN). We previously showed that Ac-SDKP mediates ACE inhibitors' cardiac effects. Whether increase
Externí odkaz:
https://doaj.org/article/ad51a6b353434f67b21128c947a723c1
Autor:
Duo-Yao Cao, Suguru Saito, Luciana C. Veiras, Derick Okwan-Duodu, Ellen A. Bernstein, Jorge F. Giani, Kenneth E. Bernstein, Zakir Khan
Publikováno v:
Cellular & Molecular Biology Letters, Vol 25, Iss 1, Pp 1-12 (2020)
Abstract Angiotensin-converting enzyme (ACE), a dicarboxypeptidase, plays a major role in the regulation of blood pressure by cleaving angiotensin I into angiotensin II (Ang II), a potent vasoconstrictor. Because of its wide substrate specificity and
Externí odkaz:
https://doaj.org/article/94854cb79e4947a19e3ca3da80b071fd
Autor:
Zhenzi Peng, Cuiwei Liu, Aaron R. Victor, Duo-Yao Cao, Luciana C. Veiras, Ellen A. Bernstein, Zakir Khan, Jorge F. Giani, Xiaojiang Cui, Kenneth E. Bernstein, Derick Okwan-Duodu
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
Granulocytes are key players in cancer metastasis. While tumor-induced de novo expansion of immunosuppressive myeloid-derived suppressor cells (MDSCs) is well-described, the fate and contribution of terminally differentiated mature neutrophils to the
Externí odkaz:
https://doaj.org/article/172498add4db402ab102601c328e4a79
Autor:
Suguru Saito, Narihito Tatsumoto, Duo-Yao Cao, Nobuyuki Nosaka, Hiroshi Nishi, Daniel N. Leal, Ellen Bernstein, Kenichi Shimada, Moshe Arditi, Kenneth E. Bernstein, Michifumi Yamashita
Publikováno v:
American journal of physiology. Renal physiology. 323(4)
While angiotensin-converting enzyme (ACE) regulates blood pressure by producing angiotensin II as part of the renin-angiotensin system, we recently reported that elevated ACE in neutrophils promotes an effective immune response and increases resistan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce7453725674d3b0a04cba79e3abf9f5
https://pubmed.ncbi.nlm.nih.gov/35979968
https://pubmed.ncbi.nlm.nih.gov/35979968
Autor:
Luciana C. Veiras, Ellen A. Bernstein, DuoYao Cao, Derick Okwan-Duodu, Zakir Khan, David R. Gibb, Arantxa Roach, Rachel Skelton, Ryan M. Williams, Kenneth E. Bernstein, Jorge F. Giani
Publikováno v:
Circ Res
Background: Chronic renal inflammation has been widely recognized as a major promoter of several forms of high blood pressure including salt-sensitive hypertension. In diabetes, IL (interleukin)-6 induces salt sensitivity through a dysregulation of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f46dc290962f3e89e71fdeaec6b4e80f
https://doi.org/10.1161/circresaha.121.320239
https://doi.org/10.1161/circresaha.121.320239
Autor:
DuoYao Cao, Zakir Khan, Xiaomo Li, Suguru Saito, Ellen A Bernstein, Aaron R Victor, Faizan Ahmed, Aoi O Hoshi, Luciana C Veiras, Tomohiro Shibata, Mingtian Che, Lei Cai, Ryan E Temel, Jorge F Giani, Daniel J Luthringer, Ajit S Divakaruni, Derick Okwan-Duodu, Kenneth E Bernstein
Publikováno v:
Cardiovascular Research.
Aims The metabolic failure of macrophages to adequately process lipid is central to the etiology of atherosclerosis. Here, we examine the role of macrophage angiotensin converting enzyme (ACE) in a mouse model of PCSK9 induced atherosclerosis. Method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c17a66d85526fc6381a4157e1dcee78
https://doi.org/10.1093/cvr/cvad082
https://doi.org/10.1093/cvr/cvad082
Autor:
Patrick Vanderheyden, Thomas Unger, Hamiyet Unal, Kalyan Tirupula, Pieter B. M. W. M. Timmermans, Walter G. Thomas, Jacqueline Kemp, Sadashiva Karnik, Tadashi Inagami, Ahsan Husain, László Hunyady, Mastgugu Horiuchi, Theodore L. Goodfriend, Emanuel Escher, Satoru Eguchi, Khuraijam Dhanachandra Singh, Marc De Gasparo, Kevin J. Catt, Kenneth E. Bernstein, Wayne Alexander
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2023
The actions of angiotensin II (Ang II) are mediated by AT1 and AT2 receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Angiotensin receptors [63, 155]), which have around 30% sequence similarity. The decapeptide angiotensin I, the octa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6aa0568223f9455ac9ba57aad6721a13
https://doi.org/10.2218/gtopdb/f6/2023.1
https://doi.org/10.2218/gtopdb/f6/2023.1