Zobrazeno 1 - 10
of 262
pro vyhledávání: '"Kenneth E, Thummel"'
Autor:
Kevin A. Lidberg, Kendan Jones-Isaac, Jade Yang, Jacelyn Bain, Lu Wang, James W. MacDonald, Theo K. Bammler, Justina Calamia, Kenneth E. Thummel, Catherine K. Yeung, Stefanie Countryman, Paul Koenig, Jonathan Himmelfarb, Edward J. Kelly
Publikováno v:
npj Microgravity, Vol 10, Iss 1, Pp 1-14 (2024)
Abstract The microgravity environment aboard the International Space Station (ISS) provides a unique stressor that can help understand underlying cellular and molecular drivers of pathological changes observed in astronauts with the ultimate goals of
Externí odkaz:
https://doaj.org/article/080dc77d0559426aa337057d6101081e
Autor:
John D. Clarke, Sabrina M. Judson, Dan‐Dan Tian, Trevor O. Kirby, Rakshit S. Tanna, Adrienn Matula‐Péntek, Miklós Horváth, Matthew E. Layton, John R. White, Nadja B. Cech, Kenneth E. Thummel, Jeannine S. McCune, Danny D. Shen, Mary F. Paine
Publikováno v:
Clinical and Translational Science, Vol 16, Iss 10, Pp 1779-1790 (2023)
Abstract Green tea is a popular beverage worldwide. The abundant green tea catechin (−)‐epigallocatechin gallate (EGCG) is a potent in vitro inhibitor of intestinal UDP‐glucuronosyltransferase (UGT) activity (Ki ~2 μM). Co‐consuming green te
Externí odkaz:
https://doaj.org/article/3dfbcc53952945d38b75f821bdee7633
Autor:
Alicja Urbaniak, Kenneth E. Thummel, Ayoade N. Alade, Allan E. Rettie, Bhagwat Prasad, Amedeo De Nicolò, Jennifer H. Martin, David N. Sheppard, Michael F. Jarvis
Publikováno v:
Pharmacology Research & Perspectives, Vol 11, Iss 6, Pp n/a-n/a (2023)
Externí odkaz:
https://doaj.org/article/ea71230efd854459853282a653d1fadf
Autor:
Emily J. Cox, Allan E. Rettie, Jashvant D. Unadkat, Kenneth E. Thummel, Jeannine S. McCune, Mary F. Paine
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 2, Pp 322-329 (2022)
Abstract Pharmacokinetic drug interactions precipitated by botanical and other natural products (NPs) remain critically understudied. Investigating these complex interactions is fraught with difficulties due to the methodologic and technical challeng
Externí odkaz:
https://doaj.org/article/e20efd409a5441c4bdc59083edd30142
Autor:
Ahmed El‐Boraie, Julie‐Anne Tanner, Andy Z.X. Zhu, Katrina G. Claw, Bhagwat Prasad, Erin G. Schuetz, Kenneth E. Thummel, Koya Fukunaga, Taisei Mushiroda, Michiaki Kubo, Neal L. Benowitz, Caryn Lerman, Rachel F. Tyndale
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 1, Pp 204-220 (2022)
Abstract CYP2A6 activity, phenotyped by the nicotine metabolite ratio (NMR), is a predictor of several smoking behaviors, including cessation and smoking‐related disease risk. The heritability of the NMR is 60–80%, yet weighted genetic risk score
Externí odkaz:
https://doaj.org/article/227fec3dc8d24dc2934491cf383a5b28
Autor:
Krista R. Schaefer, Jaedon P. Avey, Michael R. Todd, Julie A. Beans, Denise A. Dillard, Laura M. Shireman, Timothy A. Thornton, Rachel F. Tyndale, Kenneth E. Thummel, Renee F. Robinson, Katrina G. Claw
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 6, Pp 2474-2486 (2021)
Abstract Prevalence of smoking is higher in Alaska Native and American Indian (ANAI) populations living in Alaska than the general US population. Genetic factors contribute to smoking and cessation rates. The objective of this study was to compare CY
Externí odkaz:
https://doaj.org/article/6b432934769e459884438c5771c4f6b3
Autor:
Alison E. Fohner, Rachel Dalton, Kasse Skagen, Konner Jackson, Katrina G. Claw, Scarlett E. Hopkins, Renee Robinson, Burhan A. Khan, Bhagwat Prasad, Erin G. Schuetz, Deborah A. Nickerson, Timothy A. Thornton, Denise A. Dillard, Bert B. Boyer, Kenneth E. Thummel, Erica L. Woodahl
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 4, Pp 1292-1302 (2021)
Abstract The frequencies of genetic variants in the CYP3A4 and CYP3A5 genes differ greatly across global populations, leading to profound differences in the metabolic activity of these enzymes and resulting drug metabolism rates, with important conse
Externí odkaz:
https://doaj.org/article/18c815b78eaf46c482f67ddc2280dfe6
Autor:
Abdul Basit, Bhagwat Prasad, Joanne K. Estergreen, Daniel E. Sabath, Nathan Alade, David L. Veenstra, Allan E. Rettie, Kenneth E. Thummel
Publikováno v:
Clinical and Translational Science, Vol 13, Iss 4, Pp 718-726 (2020)
Warfarin is a narrow therapeutic index anticoagulant drug and its use is associated with infrequent but significant adverse bleeding events. The international normalized ratio (INR) is the most commonly used biomarker to monitor and titrate warfarin
Externí odkaz:
https://doaj.org/article/606c3ebd3fce494c85b4dd491ba170ea
Autor:
Rachel Dalton, Seung‐been Lee, Katrina G. Claw, Bhagwat Prasad, Brian R. Phillips, Danny D. Shen, Lai Hong Wong, Mitch Fade, Matthew G. McDonald, Maitreya J. Dunham, Douglas M. Fowler, Allan E. Rettie, Erin Schuetz, Timothy A. Thornton, Deborah A. Nickerson, Andrea Gaedigk, Kenneth E. Thummel, Erica L. Woodahl
Publikováno v:
Clinical and Translational Science, Vol 13, Iss 1, Pp 147-156 (2020)
The cytochrome P450 2D6 (CYP2D6) gene locus is challenging to accurately genotype due to numerous single nucleotide variants and complex structural variation. Our goal was to determine whether the CYP2D6 genotype‐phenotype correlation is improved w
Externí odkaz:
https://doaj.org/article/16a9484280914410be57114d167f3ce5
Autor:
Rosalyn J. Singleton, Gretchen M. Day, Timothy K. Thomas, Joseph A. Klejka, Christine A. Desnoyers, Melanie N. P. McIntyre, David M. Compton, Kenneth E. Thummel, Robert J. Schroth, Leanne M. Ward, Dane C. Lenaker, Rachel K. Lescher, Joseph B. McLaughlin
Publikováno v:
Nutrients, Vol 14, Iss 19, p 3935 (2022)
Background: Early childhood rickets increased in Alaska Native children after decreases in vitamin D-rich subsistence diet in childbearing-aged women. We evaluated the impact of routine prenatal vitamin D supplementation initiated in Alaska’s Yukon
Externí odkaz:
https://doaj.org/article/f4a38950e0154014a9287d54e48ef392