Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Kenneth Dorko"'
Autor:
Roberto Gramignoli, Veysel Tahan, Kenneth Dorko, Raman Venkataramanan, Ira J. Fox, Ewa C. S. Ellis, Massoud Vosough, Stephen C. Strom Ph.D.
Publikováno v:
Cell Transplantation, Vol 23 (2014)
Transplantation of human hepatocytes (HTx) has gained recognition as a bridge to, or an alternative to, orthotopic liver transplantation for patients with acute liver failure or genetic defects in liver function. Although the quality of the hepatocyt
Externí odkaz:
https://doaj.org/article/6bed40ba04634a7f8187880eac103304
Autor:
Roberto Gramignoli, Kenneth Dorko, Veysel Tahan, Kristen J. Skvorak, Ewa Ellis, Carl Jorns, Bo-Goran Ericzon, Ira J. Fox, Stephen C. Strom Ph.D.
Publikováno v:
Cell Transplantation, Vol 23 (2014)
Transplantation of human hepatocytes is gaining recognition as a bridge or an alternative to orthotopic liver transplantation for patients with acute liver failure and genetic defects. Since most patients require multiple cell infusions over an exten
Externí odkaz:
https://doaj.org/article/bcebc887729d4e93b9d49cab5875bad3
Autor:
Marc C. Hansel, Roberto Gramignoli, William Blake, Julio Davila, Kristen Skvorak, Kenneth Dorko, Veysel Tahan, Brian R. Lee, Edgar Tafaleng, Jorge Guzman-Lepe, Alejandro Soto-Gutierrez, Ira J. Fox, Stephen C. Strom
Publikováno v:
Cell Transplantation, Vol 23 (2014)
Hepatocyte transplantation has been used to treat liver disease. The availability of cells for these procedures is quite limited. Human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) may be a useful source of hepatocytes for
Externí odkaz:
https://doaj.org/article/a791c72535254c10a9d800f6a525d466
Autor:
Roberto Gramignoli, Michael L. Green, Veysel Tahan, Kenneth Dorko, Kristen J. Skvorak, Fabio Marongiu, Wenchen Zao, Raman Venkataramanan, Ewa C. S. Ellis, David Geller, Andrew G. Breite, Francis E. Dwulet, Robert C. McCarthy, Stephen C. Strom Ph.D.
Publikováno v:
Cell Transplantation, Vol 21 (2012)
Human hepatocyte transplantation is gaining acceptance for the treatment of liver diseases. However, the reagents used to isolate hepatocytes from liver tissue are not standardized and show lot-to-lot variability in enzyme activity and endotoxin cont
Externí odkaz:
https://doaj.org/article/fd049f3f0edf4d069c99a21a0682e513
Autor:
Kenneth Dorko, Paul D. Freeswick, Fabio Bartoli, Luca Cicalese, Brent A. Bardsley, Andreas Tzakis, Andreas K. Nussler
Publikováno v:
Cell Transplantation, Vol 3 (1994)
Large numbers of human hepatocytes were obtained from split and whole livers by using an adaptive form of the collagenase perfusion technique employed in rodent and human biopsies. In order to guarantee a homogenous distribution of the perfusate with
Externí odkaz:
https://doaj.org/article/c87b6fe08350445395ea11e6b9400db9
Autor:
Kyle Soltys, Kimberly Haberman, Chethan Ashokkumar, Jason V. Fong, Rachel Sada, George V. Mazariegos, Alexandra Dreyzin, Veysel Tahan, Sarangarajan Ranganathan, Donna B. Stolz, Ken Fukumitsu, Rakesh Sindhi, Chandan Guha, Kevin M. Baskin, Steven F. Dobrowolski, Rajavel Elango, Benjamin L. Shneider, Miguel Reyes-Múgica, Mubina Quader, John J. Crowley, Edgar N. Tafaleng, Kenneth Dorko, Roberto Gramignoli, Stephen C. Strom, Alejandro Soto Gutiérrez, Masaki Nagaya, Robert H. Squires, Jeffrey L. Platt, Ira J. Fox, Gerard Vockley, Taichiro Nishikawa, Marilia Cascalho, Jayanta Roy-Chowdhury, Melvin Deutsch, Kentaro Setoyama
Publikováno v:
Journal of Hepatology. 66:987-1000
Background & Aims Hepatocyte transplantation partially corrects genetic disorders and has been associated anecdotally with reversal of acute liver failure. Monitoring for graft function and rejection has been difficult, and has contributed to limited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59f259d685917f4037b28bec82b05fb9
https://doi.org/10.1016/j.jhep.2016.12.017
https://doi.org/10.1016/j.jhep.2016.12.017
Autor:
Nicholas Giebel, Ronald N. Hines, Roberto Gramignoli, Ke Yan, Pippa Simpson, Kenneth Dorko, Stephen C. Strom, Jeffrey D Shadley, D. Gail McCarver
Publikováno v:
Drug Metabolism and Disposition. 44:1027-1037
Variability in drug-metabolizing enzyme developmental trajectories contributes to interindividual differences in susceptibility to chemical toxicity and adverse drug reactions, particularly in the first years of life. Factors linked to these interind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5212a7e81661f5cd2f268e050b7d132
https://doi.org/10.1124/dmd.116.069344
https://doi.org/10.1124/dmd.116.069344
Autor:
Yuchao Xie, Wen-Xing Ding, Kenneth Dorko, Sean C. Kumer, Mitchell R. McGill, Hartmut Jaeschke, Kuo Du, Timothy M. Schmitt
Publikováno v:
Toxicology and Applied Pharmacology. 289:213-222
3'-Hydroxyacetanilide orN-acetyl-meta-aminophenol (AMAP) is generally regarded as a non-hepatotoxic analog of acetaminophen (APAP). Previous studies demonstrated the absence of toxicity after AMAP in mice, hamsters, primary mouse hepatocytes and seve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7919bf9a0857f60b403a1087ecad667e
https://doi.org/10.1016/j.taap.2015.09.022
https://doi.org/10.1016/j.taap.2015.09.022
Autor:
Antonio Artigues, Benjamin Roberts, Maria T. Villar, Atta Nawabi, Irina Tikhanovich, Kenneth Dorko, Steven A. Weinman, Sudhakiranmayi Kuravi
Publikováno v:
Journal of Biological Chemistry. 290:22236-22249
Arginine methylation is a common post-translational modification, but its role in regulating protein function is poorly understood. This study demonstrates that, TNF receptor-associated factor 6 (TRAF6), an E3 ubiquitin ligase involved in innate immu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c79b38e8f25d0edfce7fa1e42d054b89
https://doi.org/10.1074/jbc.m115.653543
https://doi.org/10.1074/jbc.m115.653543
Autor:
Milan Kos, Mitchell R. McGill, Sean C. Kumer, Timothy M. Schmitt, Yuchao Xie, Kenneth Dorko, Hartmut Jaeschke, Benjamin L. Woolbright
Publikováno v:
Journal of clinical and translational research, 1(2), 100-106
BACKGROUND Acetaminophen (APAP) hepatotoxicity is a major cause of acute liver failure in many countries. Mechanistic studies in mice and humans have implicated formation of a reactive metabolite, mitochondrial dysfunction and oxidant stress as criti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5c823536513fa04a68fc93d4e03e6a0
https://doi.org/10.18053/jctres.201502.004
https://doi.org/10.18053/jctres.201502.004