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pro vyhledávání: '"Kenneth Doring"'
Autor:
William E. Palmer, Steven Wesolowski, James M. Hulsizer, Jay Liu, Megan M. King, Khanh Bui, John P. McCauley, Thomas J. Hudzik, Valerie Hoesch, Kelly Brush, Xia Wang, Donald Andisik, Cathy Dantzman, William Frietze, Glen Ernst, Kenneth Doring
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(2)
A novel series of piperazine derivatives exhibits sub-nanomolar binding and enhanced subtype selectivity as δ-opioid agonists. The synthesis and SAR are described as well as the application of computational models to improve in vitro ADME and safety