Výsledky vyhledávání - "Kenneth Dale Brady"

Personalized Blood Pressure Management During Cardiac Surgery With Cerebral Autoregulation Monitoring: A Randomized Trial

Autor: Charles W. Hogue, Jordan Grafman, Yohei Nomura, Kenneth Dale Brady, Masa Ono, Nina Srdanovic, Lauren C. Balmert, Daijiro Hori, Charles H. Brown

Publikováno v: Seminars in Thoracic and Cardiovascular Surgery. 33:429-438

The purpose of this study was to determine if setting mean arterial pressure (MAP) targets during cardiopulmonary bypass (CPB) based on individualized cerebral autoregulation data reduces the frequency of neurological complications compared with usua

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3d14b93e7a0cb98d93c9a55d9f979bb
https://doi.org/10.1053/j.semtcvs.2020.09.032

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Real-Time Intraoperative Determination and Reporting of Cerebral Autoregulation State Using Near-Infrared Spectroscopy

Autor: Andre Antunes, Charles H. Brown, Charles W. Hogue, Mitsunori Nakano, Yohei Nomura, Kenneth Dale Brady, Paul S. Addison, Dean Montgomery

Publikováno v: Anesthesia and Analgesia

Background Cerebral blood flow (CBF) is maintained over a range of blood pressures through cerebral autoregulation (CA). Blood pressure outside the range of CA, or impaired autoregulation, is associated with adverse patient outcomes. Regional oxygen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b9edda681d8d7c33ce9f1bf479ac2cb
https://doi.org/10.1213/ane.0000000000004614

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Neurologic Injury in Neonates Undergoing Cardiac Surgery

Autor: Kenneth Dale Brady, Ronald B. Easley, Erin A. Gottlieb, Dean B. Andropoulos

Publikováno v: Clinics in Perinatology. 46:657-671

Neurodevelopmental outcomes after neonatal congenital heart surgery are significantly influenced by brain injury detectable by MRI imaging techniques. This brain injury can occur in the prenatal and postnatal periods even before cardiac surgery. Give

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86e48997420ae9ca00ad2198dc3a1e0e
https://doi.org/10.1016/j.clp.2019.08.003

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Cerebral autoregulation in the operating room and intensive care unit after cardiac surgery

Autor: Kenneth Dale Brady, Charles W. Hogue, Yohei Nomura, Atsushi Yamaguchi, Chun W. Choi, Elizabeth Colantuoni, Brian Bush, Jennifer S. Lawton, Marc S. Sussman, Ahmet Kilic, Matthew Wen, Kei Akiyoshi, Charles H. Brown, Stefano Schena, Mitsunori Nakano, Glenn J. Whitman, Karin J. Neufeld, Peter Smielewski

Publikováno v: Br J Anaesth

BACKGROUND: Cerebral autoregulation monitoring is a proposed method to monitor perfusion during cardiac surgery. However, limited data exist from the ICU as prior studies have focused on intraoperative measurements. Our objective was to characterise

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8889718890b2b8fa14de11664d8224e1
https://europepmc.org/articles/PMC8132879/

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Succinic acid amides as P2–P3 replacements for inhibitors of interleukin-1β converting enzyme (ICE or caspase 1)

Autor: Paul Galatsis, John R. Rubin, Robert V. Talanian, Bradley William Caprathe, Kenneth Dale Brady, Catherine R. Kostlan, Sheehan Susan M, Anthony Thomas, Charles J. Stankovic, Elizabeth A. Lunney, William Glen Harter, Kristin Linn, John Gilmore, Hamish Allen

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 20:5184-5190

Succinic acid amides have been found to be effective P2-P3 scaffold replacements for peptidic ICE inhibitors. Heteroarylalkyl fragments occupying the P4 position provided access to compounds with nM affinities. Utilization of an acylal prodrug moiety

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddf2f262272e5a65fdee6b2dda3e873d
https://doi.org/10.1016/j.bmcl.2010.07.004

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Structure-based design of caspase-1 inhibitor containing a diphenyl ether sulfonamide

Autor: John R. Rubin, Nigel Walker, Kenneth Dale Brady, Winnie W. Wong, Mark S. Plummer, Christine Humblet, Charles J. Stankovic, Aurash B Shahripour, Connolly Michael Kevin, Robert V. Talanian, Elizabeth A. Lunney, Hamish Allen, Tomi K. Sawyer

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 11:2779-2782

A series of compounds was designed and prepared as inhibitors of interleukin-1β converting enzyme (ICE), also known as caspase-1. These inhibitors, which employ a diphenyl ether sulfonamide, were designed to improve potency by forming favorable inte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c47eb57b7648d9c7fe525bc0e5d7800
https://doi.org/10.1016/s0960-894x(01)00573-x

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Stability and Oligomeric Equilibria of Refolded Interleukin-1β Converting Enzyme

Autor: Kenneth Dale Brady, Jeffrey P. Welch, Robert V. Talanian, John A. Mankovich, Luan C. Dang, Winnie W. Wong, Maria Hackett, Catherine R. Ferenz

Publikováno v: Journal of Biological Chemistry. 271:21853-21858

We report the preparation and characterization of interleukin-1beta converting enzyme (ICE) refolded from its p20 and p10 protein fragments. Refolded ICE heterodimer (p20p10) was catalytically active but unstable, and in size exclusion chromatography

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a805bd5acc56b372838dbe3458dadd0e
https://doi.org/10.1074/jbc.271.36.21853

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