Výsledky vyhledávání - "Kenneth D. Wild"

AMG2850, a potent and selective TRPM8 antagonist, is not effective in rat models of inflammatory mechanical hypersensitivity and neuropathic tactile allodynia

Autor: Cheryl L. Stucky, Patrick C. Kerstein, Maosheng Zhang, Kenneth D. Wild, Beth D. Youngblood, Carl Davis, Judy Wang, Weiya Wang, Andy D. Weyer, Sonya G. Lehto, Narender R. Gavva

Publikováno v: Naunyn-Schmiedeberg's Archives of Pharmacology

TRPM8 has been implicated in pain and migraine based on dorsal root- and trigeminal ganglion-enriched expression, upregulation in preclinical models of pain, knockout mouse studies, and human genetics. Here, we evaluated the therapeutic potential in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3200e74bacd3a064fa87df6decbd3609
https://doi.org/10.1007/s00210-015-1090-9

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Peptide antagonists of the calcitonin gene-related peptide (CGRP) receptor with improved pharmacokinetics and pharmacodynamics

Autor: Eileen Johnson, Jerry Ryan Holder, Barton H. Manning, Licheng Shi, Kevin Salyers, Michael Stenkilsson, Colin V. Gegg, Marie E. Wright, George Doellgast, Kenneth D. Wild, Les P. Miranda

Publikováno v: Biopolymers. 100:422-430

Antagonism of the calcitonin gene-related peptide (CGRP) receptor may be a useful approach for migraine treatment. Selective PEGylated peptide antagonists to the CGRP receptor are described, derived from CGRP(8-37) with polymer derivatization at an e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1ea37007135bf79af7cc0c5558bc94bf
https://doi.org/10.1002/bip.22270

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Selective antagonism of TRPA1 produces limited efficacy in models of inflammatory- and neuropathic-induced mechanical hypersensitivity in rats

Autor: Bryan D. Moyer, Kenneth D. Wild, Beth D. Youngblood, Ruoyuan Yin, Stephanie D. Geuns-Meyer, Weiya Wang, Narender R. Gavva, Cheryl L. Stucky, Yohannes Teffera, Maosheng Zhang, Andy D. Weyer, Sonya G. Lehto, Laurie B. Schenkel, Melanie Cooke

Publikováno v: Molecular Pain

The transient receptor potential ankyrin 1 (TRPA1) channel has been implicated in pathophysiological processes that include asthma, cough, and inflammatory pain. Agonists of TRPA1 such as mustard oil and its key component allyl isothiocyanate (AITC)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b35562945641692797c3a369d322e88
http://europepmc.org/articles/PMC5131813

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Expression Profile of Nerve Growth Factor after Muscle Incision in the Rat

Autor: Jun Xu, Timothy J. Brennan, Kenneth D. Wild, Mark Erickson, Chaoran Wu

Publikováno v: Anesthesiology. 110:140-149

Background Previous studies have demonstrated that nerve growth factor (NGF) is an important mediator of pathologic pain. Many studies have focused on cutaneous mechanisms for NGF-induced hyperalgesia; few have examined its contribution in deeper tis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c43bd71698772c5b1eed7934efb44c47
https://doi.org/10.1097/aln.0b013e318190bc84

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Identification of Potent, Selective, and Metabolically Stable Peptide Antagonists to the Calcitonin Gene-Related Peptide (CGRP) Receptor

Autor: Licheng Shi, Jennifer Aral, Richard S. Rogers, Violeta G. Valladares, Hongyan Li, Marie E. Wright, Kevin Salyers, Eileen Johnson, Jerry Ryan Holder, Les P. Miranda, Kenneth W. Walker, George Doellgast, Colin V. Gegg, Kenneth D. Wild, Brian D. Bennett

Publikováno v: Journal of Medicinal Chemistry. 51:7889-7897

Calcitonin gene-related peptide (CGRP) is a 37-residue neuropeptide that can be converted to a CGRP(1) receptor antagonist by the truncation of its first seven residues. CGRP(8-37), 1, has a CGRP(1) receptor K(i) = 3.2 nM but is rapidly degraded in h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d6e67e4b147d3e6c1d74e860256269e
https://doi.org/10.1021/jm8009298

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Antibodies to Nerve Growth Factor Reverse Established Tactile Allodynia in Rodent Models of Neuropathic Pain without Tolerance

Autor: Tie J. Zhang, James W. Davis, Di Bian, Jean-Claude Louis, Dawn Zhu, Anthony W. Bannon, Kenneth D. Wild

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 322:282-287

A considerable body of evidence implicates endogenous nerve growth factor (NGF) in conditions in which pain is a prominent feature, including neuropathic pain. However, previous studies of NGF antagonism in animal models of neuropathic pain have exam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e3a431b86cb3f907016e75353b71c20
https://doi.org/10.1124/jpet.106.116236

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Pharmacologic Characterization of AMG 334, a Potent and Selective Human Monoclonal Antibody against the Calcitonin Gene-Related Peptide Receptor

Autor: David C. Immke, Brian Smith, Jianhua Zhang, Hong Sun, Sonya G. Lehto, Licheng Shi, Kenneth D. Wild, Cen Xu, Dawn Zhu

Publikováno v: The Journal of pharmacology and experimental therapeutics. 356(1)

Therapeutic agents that block the calcitonin gene-related peptide (CGRP) signaling pathway are a highly anticipated and promising new drug class for migraine therapy, especially after reports that small-molecule CGRP-receptor antagonists are efficaci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::340896e6a0d2bcae597f2094e3303776
https://pubmed.ncbi.nlm.nih.gov/26559125

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AMG 9810 [(E)-3-(4-t-Butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a Novel Vanilloid Receptor 1 (TRPV1) Antagonist with Antihyperalgesic Properties

Autor: Narender R. Gavva, James J. S. Treanor, Todd W. Vanderah, Yusheng Qu, Jean Claude Louis, Tie J. Zhang, Frank Porreca, Kenneth D. Wild, Elizabeth M. Doherty, Rami Tamir, David C. Immke, Anthony W. Bannon, Mark H. Norman, Lana Klionsky, Judy Wang, Dawn Zhu

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 313:474-484

The vanilloid receptor 1 (VR1 or TRPV1) is a membrane-bound, nonselective cation channel expressed by peripheral sensory neurons. TRPV1 antagonists produce antihyperalgesic effects in animal models of inflammatory and neuropathic pain. Here, we descr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baa997157a9236df5940afebfb38eb8c
https://doi.org/10.1124/jpet.104.079855

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EHMTI-0315. AMG 334, the first potent and selective human monoclonal antibody antagonist against the CGRP receptor

Autor: Hong Sun, David C. Immke, Sonya G. Lehto, Licheng Shi, Dawn Zhu, Cen Xu, Kenneth D. Wild, S Rao, C King

Publikováno v: The Journal of Headache and Pain

Results AMG 334 is a potent inhibitor of [125I]-CGRP binding to the human CGRP receptor with a Ki of 0.02 nM. It exhibited full inhibition of CGRP-stimulated cAMP production with an IC50 of 2.3 nM in cell-based functional assays. Potency of AMG 334 a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::645f17a7c667733da39e329681f57125
https://doi.org/10.1186/1129-2377-15-s1-g43

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