Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Kenneth D. R., Setchell"'
Autor:
Lauren E. Lynch, Amy B. Hair, Krishnakant G. Soni, Heeju Yang, Laura A. Gollins, Monica Narvaez-Rivas, Kenneth D. R. Setchell, Geoffrey A. Preidis
Publikováno v:
Gut Microbes, Vol 15, Iss 1 (2023)
ABSTRACTCholestasis refers to impaired bile flow from the liver to the intestine. In neonates, cholestasis causes poor growth and may progress to liver failure and death. Normal bile flow requires an intact liver-gut-microbiome axis, whereby liver-de
Externí odkaz:
https://doaj.org/article/cf75c6c890bb454fb1142d1509e88475
Autor:
Kathleen M. Loomes, Robert H. Squires, Deirdre Kelly, Sanjay Rajwal, Nisreen Soufi, Alain Lachaux, Irena Jankowska, Cara Mack, Kenneth D. R. Setchell, Palaniswamy Karthikeyan, Ciara Kennedy, Alejandro Dorenbaum, Nirav K. Desai, Will Garner, Thomas Jaecklin, Pamela Vig, Alexander Miethke, Richard J. Thompson
Publikováno v:
Hepatology Communications, Vol 6, Iss 9, Pp 2379-2390 (2022)
Abstract Children with progressive familial intrahepatic cholestasis, including bile salt export pump (BSEP) and familial intrahepatic cholestasis–associated protein 1 (FIC1) deficiencies, suffer debilitating cholestatic pruritus that adversely aff
Externí odkaz:
https://doaj.org/article/b1254fad7eda4d029fb251fe1e6c2b23
Autor:
Aristotelis Astrinidis, Chenggang Li, Erik Y. Zhang, Xueheng Zhao, Shuyang Zhao, Minzhe Guo, Tasnim Olatoke, Ushodaya Mattam, Rong Huang, Alan G. Zhang, Lori Pitstick, Elizabeth J. Kopras, Nishant Gupta, Roman Jandarov, Eric P. Smith, Elizabeth Fugate, Diana Lindquist, Maciej M. Markiewski, Magdalena Karbowniczek, Kathryn A. Wikenheiser-Brokamp, Kenneth D. R. Setchell, Francis X. McCormack, Yan Xu, Jane J. Yu
Publikováno v:
JCI Insight, Vol 8, Iss 9 (2023)
Tuberous sclerosis complex (TSC) is characterized by multisystem, low-grade neoplasia involving the lung, kidneys, brain, and heart. Lymphangioleiomyomatosis (LAM) is a progressive pulmonary disease affecting almost exclusively women. TSC and LAM are
Externí odkaz:
https://doaj.org/article/ad95cbd9b11f46108c30b103c315f140
Autor:
Jing Zhao, Kenneth D. R. Setchell, Ying Gong, Yinghua Sun, Ping Zhang, James E. Heubi, Lingjuan Fang, Yi Lu, Xinbao Xie, Jingyu Gong, Jian-She Wang
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 16, Iss 1, Pp 1-15 (2021)
Abstract Background Biallelic variants in HSD3B7 cause 3β-hydroxy-Δ5-C27-steroid oxidoreductase (HSD3B7) deficiency, a life-threatening but treatable liver disease. The goal of this study was to obtain detailed information on the correlation betwee
Externí odkaz:
https://doaj.org/article/5f7256cd653545d5b45ec79e65978242
Publikováno v:
BMC Gastroenterology, Vol 21, Iss 1, Pp 1-10 (2021)
Abstract Background Deficiency of oxysterol 7α-hydroxylase, encoded by CYP7B1, is associated with fatal infantile progressive intrahepatic cholestasis and hereditary spastic paraplegia type 5. Most reported patients with CYP7B1 mutations presenting
Externí odkaz:
https://doaj.org/article/ffe6596b0914420b9aa929481796ebfa
Autor:
Monica Narvaez-Rivas, Kenneth D. R. Setchell, Stephanie L. Galandi, Xueheng Zhao, Najeeha Talat Iqbal, Sheraz Ahmed, Junaid Iqbal, Sana Syed, Syed Asad Ali, Sean R. Moore
Publikováno v:
Metabolites, Vol 13, Iss 4, p 489 (2023)
Environmental enteric dysfunction (EED) is characterized by intestinal inflammation, malabsorption and growth-faltering in children with heightened exposure to gut pathogens. The aim of this study was to characterize serum non-esterified fatty acids
Externí odkaz:
https://doaj.org/article/17af260fd59746a8b8c3e01837881a22
Autor:
Kenneth D. R. Setchell, Evangelia Mourvaki, Carlo Clerici, Simona Mattioli, Gabriele Brecchia, Cesare Castellini
Publikováno v:
Metabolites, Vol 12, Iss 11, p 1112 (2022)
This study compared dietary isoflavone aglycones with the glycoside conjugates in a novel model of postmenopausal status, the aging domestic hen (Gallus gallus domesticus), to determine the effects on reproductive performance, cholesterol levels, and
Externí odkaz:
https://doaj.org/article/fb063fbf8ca64cfbaa65d5dbc45c3022
Publikováno v:
Metabolites, Vol 12, Iss 10, p 952 (2022)
Progressive familial intrahepatic cholestasis (PFIC) is a debilitating disease manifest by severe cholestasis, intractable pruritus and growth delay that ultimately leads to liver failure or transplantation. Maralixibat (MRX) was recently approved fo
Externí odkaz:
https://doaj.org/article/b561f82ea28b4ea2bbe796c0359cf58f
Autor:
Najeeha T. Iqbal, Sana Syed, Kamran Sadiq, Marium N. Khan, Junaid Iqbal, Jennie Z. Ma, Fayaz Umrani, Sheraz Ahmed, Elizabeth A. Maier, Lee A. Denson, Yael Haberman, Monica M. McNeal, Kenneth D. R. Setchell, Xueheng Zhao, Shahida Qureshi, Lanlan Shen, Christopher A. Moskaluk, Ta-Chiang Liu, Omer Yilmaz, Donald E. Brown, Michael J. Barratt, Vanderlene L. Kung, Jeffrey I. Gordon, Sean R. Moore, S. Asad Ali
Publikováno v:
BMC Pediatrics, Vol 19, Iss 1, Pp 1-17 (2019)
Abstract Background Environmental Enteropathy (EE), characterized by alterations in intestinal structure, function, and immune activation, is believed to be an important contributor to childhood undernutrition and its associated morbidities, includin
Externí odkaz:
https://doaj.org/article/0414bfb214f044bf863c410800397858
Autor:
Yanyan Peng, Benjamin Liou, Yi Lin, Venette Fannin, Wujuan Zhang, Ricardo A. Feldman, Kenneth D. R. Setchell, Gregory A. Grabowski, Ying Sun
Publikováno v:
Cells, Vol 10, Iss 9, p 2286 (2021)
Substrate reduction therapy (SRT) in clinic adequately manages the visceral manifestations in Gaucher disease (GD) but has no direct effect on brain disease. To understand the molecular basis of SRT in GD treatment, we evaluated the efficacy and unde
Externí odkaz:
https://doaj.org/article/2a17195a72704fc382691fa67a91cebb