Gradual hypertension induction in middle‐aged Cyp1a1‐Ren2 transgenic rats produces significant impairments in spatial learning

Autor: Gene E. Alexander, Lauren A Biwer, Theodore P. Trouard, Matthew De Both, Marc A. Zempare, Ajay R. Uprety, Paul D. Coleman, Monica K. Chawla, Lan T. Hoang, Megan C. Fitzhugh, Mari N. Willeman, Carol A. Barnes, Taben M. Hale, Matthew J. Huentelman, Kenneth D. Mitchell

Publikováno v: Physiological Reports, Vol 7, Iss 6, Pp n/a-n/a (2019)
Physiological Reports

Hypertension is a major health concern in the developed world, and its prevalence increases with advancing age. The impact of hypertension on the function of the renal and cardiovascular systems is well studied; however, its influence on the brain re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b14846c36626c1f319713eb7a4aed55a
https://doaj.org/article/76adeb50b6b241eeacdba5989ffac95c

Training Medical Students in Research: The DeBakey Scholars Program at Tulane University School of Medicine

Autor: Kenneth D. Mitchell, N. Kevin Krane

Publikováno v: Medical Science Educator. 23:385-390

Introduction There is growing awareness that research training forms an important part of medical student education, and many students welcome the opportunity to participate in research activities if the opportunity is provided.1,2 Over half of gradu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fe58595b92baa1cea6ecc5b6223c1ac3
https://doi.org/10.1007/bf03341650

Increased neuronal activity in the OVLT of Cyp1a1-Ren2 transgenic rats with inducible Ang II-dependent malignant hypertension

Autor: Andrei V. Derbenev, Alexandra T. Issa, Kayoko Miyata, Vibol Heng, Kenneth D. Mitchell

Publikováno v: Neuroscience Letters. 519:26-30

The contribution of angiotensin II (Ang II) to the pathophysiology of hypertension is established based on facts that high levels of circulating Ang II increase vasoconstriction of peripheral arteries causing a rise in blood pressure (BP). In additio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af0222995239dc337a95f7c30991e1e0
https://doi.org/10.1016/j.neulet.2012.05.006

The complex interplay between cyclooxygenase-2 and angiotensin II in regulating kidney function

Autor: Kenneth D. Mitchell, Torrance Green, Alexis A. Gonzalez, L. Gabriel Navar

Publikováno v: Current Opinion in Nephrology & Hypertension. 21:7-14

Purpose of reviewCyclooxygenase-2 (COX-2) plays a critical role in modulating deleterious actions of angiotensin II (Ang II) where there is an inappropriate activation of the renin–angiotensin system (RAS). This review discusses the recent developm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::53b7b1834225e9fd12295da37e6dcc50
https://doi.org/10.1097/mnh.0b013e32834d9d75

AT1 Receptor Blockade Prevents the Increase in Blood Pressure and the Augmentation of Intrarenal ANG II Levels in Hypertensive Cyp1a1-Ren2 Transgenic Rats Fed With a High-Salt Diet

Autor: Dustyn E. Williams, L. Gabriel Navar, Minolfa C. Prieto, John J. Mullins, Kenneth D. Mitchell

Publikováno v: Williams, D E, Prieto, M C, Mullins, J J, Navar, L G & Mitchell, K D 2010, ' AT1 Receptor Blockade Prevents the Increase in Blood Pressure and the Augmentation of Intrarenal ANG II Levels in Hypertensive Cyp1a1-Ren2 Transgenic Rats Fed With a High-Salt Diet ', American Journal of the Medical Sciences, vol. 339, no. 4, pp. 356-361 . https://doi.org/10.1097/MAJ.0b013e3181d2b0a8

Introduction This study was performed to determine the effects of high-salt diet on the magnitude of the increases in systolic blood pressure (SBP) and kidney tissue angiotensin (ANG) II levels that occur after induction of ANG II-dependent malignant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23e844e72062b407d5ca1247afef3c20
https://doi.org/10.1097/maj.0b013e3181d2b0a8