Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Kenneth D. Greis"'
Autor:
Laura Barreyro, Avery M. Sampson, Kathleen Hueneman, Kwangmin Choi, Susanne Christie, Vighnesh Ramesh, Michael Wyder, Dehua Wang, Mario Pujato, Kenneth D. Greis, Gang Huang, Daniel T. Starczynowski
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109809- (2024)
Summary: Dysregulated innate immune signaling is linked to preleukemic conditions and myeloid malignancies. However, it is unknown whether sustained innate immune signaling contributes to malignant transformation. Here we show that cell-intrinsic inn
Externí odkaz:
https://doaj.org/article/27e314a429b04c5388a0550ebdd9ec6f
Autor:
Yasuaki Uehara, Yusuke Tanaka, Shuyang Zhao, Nikolaos M. Nikolaidis, Lori B. Pitstick, Huixing Wu, Jane J. Yu, Erik Zhang, Yoshihiro Hasegawa, John G. Noel, Jason C. Gardner, Elizabeth J. Kopras, Wendy D. Haffey, Kenneth D. Greis, Jinbang Guo, Jason C. Woods, Kathryn A. Wikenheiser-Brokamp, Jennifer E. Kyle, Charles Ansong, Steven L. Teitelbaum, Yoshikazu Inoue, Göksel Altinişik, Yan Xu, Francis X. McCormack
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Osteoclasts are derived from circulating myeloid cells to mediate bone repair, maintenance and remodeling. Here, the authors show that the lung also recruits and reprograms monocytes and alveolar macrophages into osteoclast-like cells to clear pathog
Externí odkaz:
https://doaj.org/article/31bc357b81304579bc6ef7c4759424c7
Publikováno v:
Biochemistry and Biophysics Reports, Vol 30, Iss , Pp 101278- (2022)
Tetranitromethane was used to selectively modify tyrosine residues of a humanized anti-cocaine mAb (h2E2), under development for the treatment of cocaine use disorders. The effect of mild tyrosine nitration on the affinity of cocaine and two high aff
Externí odkaz:
https://doaj.org/article/3f4b4c1aaa814867a5242eccfa9154f3
Publikováno v:
Biochemistry and Biophysics Reports, Vol 16, Iss , Pp 138-144 (2018)
Monoclonal antibodies and derived fragments are used extensively both experimentally and therapeutically. Thorough characterization of such antibodies is necessary and includes assessment of their thermal and storage stabilities. Thus, assessment of
Externí odkaz:
https://doaj.org/article/72ba61bb14ba473b8064969d2b9b7325
Autor:
Erin Curry, Megan E. Philpott, Jessye Wojtusik, Wendy D. Haffey, Michael A. Wyder, Kenneth D. Greis, Terri L. Roth
Publikováno v:
Life, Vol 12, Iss 6, p 796 (2022)
Reliable pregnancy diagnostics would be beneficial for monitoring polar bear (Ursus maritimus) populations both in situ and ex situ, but currently there is no method of non-invasive pregnancy detection in this species. Recent reports in several carni
Externí odkaz:
https://doaj.org/article/2f90669015e5469987f60f9dab887635
Autor:
Madeline Niederkorn, Kathleen Hueneman, Kwangmin Choi, Melinda E. Varney, Laurel Romano, Mario A. Pujato, Kenneth D. Greis, Jun-ichiro Inoue, Ruhikanta Meetei, Daniel T. Starczynowski
Publikováno v:
Cell Reports, Vol 30, Iss 8, Pp 2776-2790.e6 (2020)
Summary: TRAF-interacting protein with a forkhead-associated domain B (TIFAB) is implicated in myeloid malignancies with deletion of chromosome 5q. Employing a combination of proteomic and genetic approaches, we find that TIFAB regulates ubiquitin-sp
Externí odkaz:
https://doaj.org/article/5461a6c7392c4dcfb7f7ff2b3992f655
Autor:
Harold W. Davis, Subrahmanya D. Vallabhapurapu, Zhengtao Chu, Michael A. Wyder, Kenneth D. Greis, Venette Fannin, Ying Sun, Pankaj B. Desai, Koon Y. Pak, Brian D. Gray, Xiaoyang Qi
Publikováno v:
Cells, Vol 9, Iss 9, p 1960 (2020)
Glioblastoma multiforme (GBM), a common type of brain cancer, has a very poor prognosis. In general, viable GBM cells exhibit elevated phosphatidylserine (PS) on their membrane surface compared to healthy cells. We have developed a drug, saposin C-di
Externí odkaz:
https://doaj.org/article/d8d42fb3d44246a289e85d2ce7e47e28
Autor:
Joshua Ruina Bennett, Chiharu Ishikawa, Puneet Agarwal, Jennifer Yeung, Avery Sampson, Emma Uible, Eric Vick, Lyndsey Bolanos, Kathleen M Hueneman, Mark Wunderlich, Amal Kolt, Kwangmin Choi, Andrew G Volk, Kenneth D Greis, Jan S. Rosenbaum, Scott Hoyt, Craig J Thomas, Daniel T Starczynowski
Publikováno v:
Blood Journal.
Dysregulation of innate immune signaling is a hallmark of hematologic malignancies. Recent therapeutic efforts to subvert aberrant innate immune signaling in MDS and AML have focused on the kinase IRAK4. IRAK4 inhibitors have achieved promising, thou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b556cf67bef65c7d2de75fe57ee9811
https://doi.org/10.1182/blood.2022018718
https://doi.org/10.1182/blood.2022018718
Autor:
Rebecca R. Crowther, Stephanie M. Schmidt, Shannon M. Lange, Melanie C. McKell, Michelle C. Robillard, Junfang Zhao, Wendy D. Haffey, Michael A. Wyder, Kenneth D. Greis, Kenneth D. R. Setchell, Joseph E. Qualls
Publikováno v:
The Journal of Immunology. 208:793-798
Metabolomics analyses suggest changes in amino acid abundance, particularly l-arginine (L-ARG), occur in patients with tuberculosis. Immune cells require L-ARG to fuel effector functions following infection. We have previously described an L-ARG synt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32417746bdf2b1490c1024d4fb3b408c
https://doi.org/10.4049/jimmunol.2100652
https://doi.org/10.4049/jimmunol.2100652
Autor:
Laura Barreyro, Avery M. Sampson, Chiharu Ishikawa, Kathleen M. Hueneman, Kwangmin Choi, Mario A. Pujato, Somchai Chutipongtanate, Michael Wyder, Wendy D. Haffey, Eric O’Brien, Mark Wunderlich, Vighnesh Ramesh, Ellen M. Kolb, Cem Meydan, Yaseswini Neelamraju, Lyndsey C. Bolanos, Susanne Christie, Molly A. Smith, Madeline Niederkorn, Tomoya Muto, Santosh Kesari, Francine E. Garrett-Bakelman, Boris Bartholdy, Britta Will, Matthew T. Weirauch, James C. Mulloy, Zartash Gul, Stephen Medlin, Rhett A. Kovall, Ari M. Melnick, John P. Perentesis, Kenneth D. Greis, Elmar Nurmemmedov, William L. Seibel, Daniel T. Starczynowski
Publikováno v:
Science Translational Medicine. 14
Dysregulation of innate immune signaling pathways is implicated in various hematologic malignancies. However, these pathways have not been systematically examined in acute myeloid leukemia (AML). We report that AML hematopoietic stem and progenitor c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aab19353bdab9af25346ff03b6c548f8
https://doi.org/10.1126/scitranslmed.abb7695
https://doi.org/10.1126/scitranslmed.abb7695