Zobrazeno 1 - 10
of 301
pro vyhledávání: '"Kenneth D. Bloch"'
Autor:
Timothy E. Thayer, Christian L. Lino Cardenas, Trejeeve Martyn, Christopher J. Nicholson, Lisa Traeger, Florian Wunderer, Charles Slocum, Haakon Sigurslid, Hannah R. Shakartzi, Caitlin O’Rourke, Georgia Shelton, Mary D. Buswell, Hanna Barnes, Leif R. Neitzel, Clara D. Ledsky, Jason Pingcheng Li, Megan F. Burke, Eric Farber-Eger, Daniel S. Perrien, Ravindra Kumar, Kathleen E. Corey, Quinn S. Wells, Kenneth D. Bloch, Charles C. Hong, Donald B. Bloch, Rajeev Malhotra
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract Non-alcoholic fatty liver disease (NAFLD) affects over 30% of adults in the United States. Bone morphogenetic protein (BMP) signaling is known to contribute to hepatic fibrosis, but the role of BMP signaling in the development of NAFLD is un
Externí odkaz:
https://doaj.org/article/0b2d4d623f694b79a8b273377b95590c
Autor:
Bodil Petersen, Cornelius J. Busch, Grigorij Schleifer, Dominik Schaack, Felix Lasitschka, Kenneth D. Bloch, Donald B. Bloch, Fumito Ichinose
Publikováno v:
Respiratory Research, Vol 20, Iss 1, Pp 1-11 (2019)
Abstract Background Hypoxic pulmonary vasoconstriction (HPV) optimizes the match between ventilation and perfusion in the lung by reducing blood flow to poorly ventilated regions. Sepsis and endotoxemia impair HPV. We previously showed that nitric ox
Externí odkaz:
https://doaj.org/article/e25ed4aa6e604622aeec12eafb54322b
Autor:
Claire Mayeur, Starsha A. Kolodziej, Amy Wang, Xin Xu, Arthur Lee, Paul B. Yu, John Shen, Kenneth D. Bloch, Donald B. Bloch
Publikováno v:
Haematologica, Vol 100, Iss 2 (2015)
Externí odkaz:
https://doaj.org/article/8b2fc628f10e4d7e90c4e7b448d3647c
Autor:
Thomas B. Bartnikas, Andrea U. Steinbicker, Dean R. Campagna, Sherika Blevins, Lanette S. Woodward, Carolina Herrera, Kenneth D. Bloch, Monica J. Justice, Mark D. Fleming
Publikováno v:
Haematologica, Vol 98, Iss 6 (2013)
Mutagenesis screens can establish mouse models of utility for the study of critical biological processes such as iron metabolism. Such screens can produce mutations in novel genes or establish novel alleles of known genes, both of which can be useful
Externí odkaz:
https://doaj.org/article/096a6cffdae6464b8c2642e2a376a2d1
Autor:
Rajeev Malhotra, Megan F Burke, Trejeeve Martyn, Hannah R Shakartzi, Timothy E Thayer, Caitlin O'Rourke, Pingcheng Li, Matthias Derwall, Ester Spagnolli, Starsha A Kolodziej, Konrad Hoeft, Claire Mayeur, Pawina Jiramongkolchai, Ravindra Kumar, Emmanuel S Buys, Paul B Yu, Kenneth D Bloch, Donald B Bloch
Publikováno v:
PLoS ONE, Vol 10, Iss 1, p e0117098 (2015)
OBJECTIVE:Matrix Gla protein (MGP) is reported to inhibit bone morphogenetic protein (BMP) signal transduction. MGP deficiency is associated with medial calcification of the arterial wall, in a process that involves both osteogenic transdifferentiati
Externí odkaz:
https://doaj.org/article/700095d416744166956ea4390b74054c
Autor:
Rajeev Malhotra, David K. Rhee, Benjamin Corman, Clara D. Ledsky, Haakon H. Sigurslid, Florian Wunderer, Aranya Bagchi, Hanna J. Barnes, Kathryn M. Peneyra, Mary D. Buswell, Charles Slocum, Kenneth D. Bloch, Kimberly B. Johansson, Daniel Bloch, Caitlin O’Rourke
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 39:178-187
Objective— Inflammatory stimuli enhance the progression of atherosclerotic disease. Inflammation also increases the expression of hepcidin, a hormonal regulator of iron homeostasis, which decreases intestinal iron absorption, reduces serum iron lev
Autor:
Bernadette O. Fernandez, Warren M. Zapol, Rajeev Malhotra, Andrea U. Steinbicker, Yasuko Nagasaka, Ester Spagnolli, Martin Feelisch, Kenneth D. Bloch, Daniel Bloch
Publikováno v:
Am J Respir Crit Care Med
BACKGROUND: Endogenous nitric oxide (NO) may contribute to ischemic and anesthetic preconditioning while exogenous NO protects against ischemia-reperfusion (I/R) injury in the heart and other organs. Why those beneficial effects observed in animal mo
Autor:
Guo Ling Zhou, Arkadi Beloiartsev, Binglan Yu, David M Baron, Weihua Zhou, Rasma Niedra, Naifang Lu, Laurel T Tainsh, Warren M Zapol, Brian Seed, Kenneth D Bloch
Publikováno v:
PLoS Genetics, Vol 9, Iss 11, p e1003950 (2013)
Epoxyeicosatrienoic acids (EETs) confer vasoactive and cardioprotective functions. Genetic analysis of the contributions of these short-lived mediators to pathophysiology has been confounded to date by the allelic expansion in rodents of the portion
Externí odkaz:
https://doaj.org/article/8dc92b3772fe40a68d870e96ab003376
Autor:
Patricio A Leyton, Hideyuki Beppu, Alexandra Pappas, Trejeeve M Martyn, Matthias Derwall, David M Baron, Rita Galdos, Donald B Bloch, Kenneth D Bloch
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e76947 (2013)
The bone morphogenetic protein (BMP) type II receptor (BMPR2) has a long cytoplasmic tail domain whose function is incompletely elucidated. Mutations in the tail domain of BMPR2 are found in familial cases of pulmonary arterial hypertension. To inves
Externí odkaz:
https://doaj.org/article/e4a3d76893d64587a5d806b229941ec2
Autor:
Rajeev Malhotra, Georgia Shelton, Quinn S. Wells, Hanna J. Barnes, Christian L. Lino Cardenas, Charles C. Hong, Leif R. Neitzel, Christopher J. Nicholson, Ravindra Kumar, Caitlin O’Rourke, Kathleen E. Corey, Lisa Traeger, Megan F. Burke, Hannah R. Shakartzi, Eric Farber-Eger, Trejeeve Martyn, Daniel Bloch, Mary D. Buswell, Haakon H. Sigurslid, Timothy E Thayer, Charles Slocum, Kenneth D. Bloch, Jason Pingcheng Li, Clara D. Ledsky, Daniel S. Perrien, Florian Wunderer
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Non-alcoholic fatty liver disease (NAFLD) affects over 30% of adults in the United States. Bone morphogenetic protein (BMP) signaling is known to contribute to hepatic fibrosis, but the role of BMP signaling in the development of NAFLD is unclear. In