Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Kenneth D Greis"'
Publikováno v:
Biomarker Insights, Vol 14 (2019)
Purpose: Distinguishing urinary tract infection (UTI) from urinary tract colonization (UTC) in children with neurogenic bladders who require clean intermittent catheterization (CIC) is challenging. Our objective was to identify urinary proteins to di
Externí odkaz:
https://doaj.org/article/dfd035db58ae4f5886b9b6529cc83829
Autor:
Michael R Bennett, LaTawnya Pleasant, Christopher Haffner, Qing Ma, Wendy D Haffey, Jun Ying, Michael Wagner, Kenneth D Greis, Prasad Devarajan
Publikováno v:
Biomarker Insights, Vol 12 (2017)
Idiopathic nephrotic syndrome (NS) is the most common glomerular disorder of childhood. Response to initial treatment with corticosteroids is an indicator of prognosis, as resistant patients often present more progressive disease. In this cross-secti
Externí odkaz:
https://doaj.org/article/02e3ce09bc374c429396c4564a42ff70
Autor:
Yan Huang, Corey Powers, Satish K Madala, Kenneth D Greis, Wendy D Haffey, Jeffrey A Towbin, Enkhsaikhan Purevjav, Sabzali Javadov, Arnold W Strauss, Zaza Khuchua
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0128561 (2015)
Cardiolipin (CL) is a mitochondrial phospholipid essential for electron transport chain (ETC) integrity. CL-deficiency in humans is caused by mutations in the tafazzin (Taz) gene and results in a multisystem pediatric disorder, Barth syndrome (BTHS).
Externí odkaz:
https://doaj.org/article/dd94a5c23f734988bfe595aef3d98094
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e16482 (2011)
Pulmonary surfactant is a complex mixture of lipids and proteins that is essential for postnatal function. Surfactant is synthesized in alveolar type II cells and stored as multi-bilayer membranes in a specialized secretory lysosome-related organelle
Externí odkaz:
https://doaj.org/article/97f4acd5b6084024be167cf6a3dcf259
Autor:
Laura Barreyro, Avery M. Sampson, Kathleen Hueneman, Kwangmin Choi, Susanne Christie, Vighnesh Ramesh, Michael Wyder, Dehua Wang, Mario Pujato, Kenneth D. Greis, Gang Huang, Daniel T. Starczynowski
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109809- (2024)
Summary: Dysregulated innate immune signaling is linked to preleukemic conditions and myeloid malignancies. However, it is unknown whether sustained innate immune signaling contributes to malignant transformation. Here we show that cell-intrinsic inn
Externí odkaz:
https://doaj.org/article/27e314a429b04c5388a0550ebdd9ec6f
Autor:
Yasuaki Uehara, Yusuke Tanaka, Shuyang Zhao, Nikolaos M. Nikolaidis, Lori B. Pitstick, Huixing Wu, Jane J. Yu, Erik Zhang, Yoshihiro Hasegawa, John G. Noel, Jason C. Gardner, Elizabeth J. Kopras, Wendy D. Haffey, Kenneth D. Greis, Jinbang Guo, Jason C. Woods, Kathryn A. Wikenheiser-Brokamp, Jennifer E. Kyle, Charles Ansong, Steven L. Teitelbaum, Yoshikazu Inoue, Göksel Altinişik, Yan Xu, Francis X. McCormack
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Osteoclasts are derived from circulating myeloid cells to mediate bone repair, maintenance and remodeling. Here, the authors show that the lung also recruits and reprograms monocytes and alveolar macrophages into osteoclast-like cells to clear pathog
Externí odkaz:
https://doaj.org/article/31bc357b81304579bc6ef7c4759424c7
Autor:
Joshua Ruina Bennett, Chiharu Ishikawa, Puneet Agarwal, Jennifer Yeung, Avery Sampson, Emma Uible, Eric Vick, Lyndsey Bolanos, Kathleen M Hueneman, Mark Wunderlich, Amal Kolt, Kwangmin Choi, Andrew G Volk, Kenneth D Greis, Jan S. Rosenbaum, Scott Hoyt, Craig J Thomas, Daniel T Starczynowski
Publikováno v:
Blood Journal.
Dysregulation of innate immune signaling is a hallmark of hematologic malignancies. Recent therapeutic efforts to subvert aberrant innate immune signaling in MDS and AML have focused on the kinase IRAK4. IRAK4 inhibitors have achieved promising, thou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b556cf67bef65c7d2de75fe57ee9811
https://doi.org/10.1182/blood.2022018718
https://doi.org/10.1182/blood.2022018718
Autor:
Rebecca R. Crowther, Stephanie M. Schmidt, Shannon M. Lange, Melanie C. McKell, Michelle C. Robillard, Junfang Zhao, Wendy D. Haffey, Michael A. Wyder, Kenneth D. Greis, Kenneth D. R. Setchell, Joseph E. Qualls
Publikováno v:
The Journal of Immunology. 208:793-798
Metabolomics analyses suggest changes in amino acid abundance, particularly l-arginine (L-ARG), occur in patients with tuberculosis. Immune cells require L-ARG to fuel effector functions following infection. We have previously described an L-ARG synt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32417746bdf2b1490c1024d4fb3b408c
https://doi.org/10.4049/jimmunol.2100652
https://doi.org/10.4049/jimmunol.2100652
Autor:
John D. Crispino, Lyndsey Bolanos, Wendy D. Haffey, Michael Schieber, Daniel T. Starczynowski, Kenneth D. Greis, Christian Marinaccio
Publikováno v:
Blood Cancer Journal, Vol 10, Iss 10, Pp 1-12 (2020)
Blood Cancer Journal
Blood Cancer Journal
Myelodysplastic syndrome (MDS) is a heterogeneous myeloid malignancy characterized by blood cell morphological dysplasia, ineffective clonal hematopoiesis, and risk of transformation to secondary acute myeloid leukemia (sAML). A number of genetic abn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::559c571ec78f8abb8a42ffa9d69ae678
http://link.springer.com/article/10.1038/s41408-020-00362-7
http://link.springer.com/article/10.1038/s41408-020-00362-7
Autor:
Jayati Mookerjee-Basu, David E. Muench, Lisa R. Trump-Durbin, H. Leighton Grimes, Kristopher L. Nazor, Kejian Zhang, Kenneth D. Greis, Kasiani C. Myers, Baobao Song, Carolyn Lutzko, Dietmar J. Kappes, Stuart Hay, Nathan Salomonis, Giang Pham, Kyle Ferchen, Rachel A. Serafin, Sing Sing Way, Pankaj Dwivedi, Jennifer C. Yu, Somchai Chutipongtanate, Andre Olsson, Kashish Chetal
Publikováno v:
Nature
Advances in genetics and sequencing have identified a plethora of disease-associated and disease-causing genetic alterations. To determine causality between genetics and disease, accurate models for molecular dissection are required; however, the rap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0208f25c4e655f04f3b0745b74f280fb
https://doi.org/10.1038/s41586-020-2227-7
https://doi.org/10.1038/s41586-020-2227-7